PI3K/mTOR inhibitor omipalisib prolongs cardiac repolarization along with a mild proarrhythmic outcome in the AV block dog model

Autor: J. J. A. van Bavel, C. Pham, H. D. M. Beekman, M. J. C. Houtman, A. Bossu, R. W. Sparidans, M. A. G. van der Heyden, M. A. Vos

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

BackgroundThe phosphoinositide 3-kinase (PI3K) signaling pathway is an interesting target in cancer treatment. The awareness of the proarrhythmic risk of PI3K inhibitors was raised because PI3K is also involved in regulating signaling toward cardiac

Externí odkaz: https://doaj.org/article/babebe5088204972a6e5d4822409d2e5

Pericardial Delivery of SDF-1α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling.

Autor: Luo L; The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523059, China.; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, 510515, China., Li Y; The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523059, China., Bao Z; Guangzhou University of Chinese Medicine, Guangzhou, 510006, China., Zhu D; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27606, USA., Chen G; Cardiology Department of Panyu Central Hospital and Cardiovascular Disease Institute of Panyu District, Guangzhou, 511400, P. R. China., Li W; The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523059, China.; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, 510515, China., Xiao Y; The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523059, China.; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, 510515, China., Wang Z; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC, 27606, USA., Zhang Y; College of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China., Liu H; College of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, 071002, China., Chen Y; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, 510515, China.; Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Liao Y; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, 510515, China.; Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Cheng K; Department of Biomedical Engineering, Columbia University, New York, 10032, USA., Li Z; The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, 523059, China.; The First School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, China.; Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, 510515, China.

Publikováno v: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Jan; Vol. 36 (1), pp. e2302686. Date of Electronic Publication: 2023 Sep 15.

Unraveling Faculty Burnout : Pathways to Reckoning and Renewal

Autor: Rebecca Pope-Ruark

A timely book about assessing, coping with, and mitigating burnout in higher education.Faculty often talk about how busy, overwhelmed, and stressed they are. These qualities are seen as badges of honor in a capitalist culture that values productivity

Perspectives in Dynamical Systems III: Control and Stability : DSTA, Łódź, Poland December 2–5, 2019

Autor: Jan Awrejcewicz

This volume is part of collection of contributions devoted to analytical and experimental techniques of dynamical systems, presented at the 15th International Conference “Dynamical Systems: Theory and Applications”, held in Łódź, Poland on Dec