Výsledky vyhledávání - "J. I. O. Craig"

Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation

Autor: Robert Marcus, J. I. O. Craig, J Ewing, R S Goodman, Craig J. Taylor, P.A. Dyer, Paul C. Evans, Kay Poulton

Publikováno v: Bone Marrow Transplantation. 36:151-156

CD31 gene polymorphisms are implicated in the pathogenesis of graft-versus-host disease (GvHD) following haematopoietic stem cell transplantation (HST). We investigated the influence of CD31 genotype on the incidence of GvHD following HST from an hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01da5f0f61dee66a7fec3ddaefeab46e
https://doi.org/10.1038/sj.bmt.1705013

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In vitroco-stimulation with anti-CD28 synergizes with IL-12 in the generation of T cell immune responses to leukaemic cells; a strategy forex-vivogeneration of CTL for immunotherapy

Autor: Mark W. Lowdell, HG Prentice, J. K. Orleans-Lindsay, A. Deru, J. I. O. Craig

Publikováno v: Clinical and Experimental Immunology. 133:467-475

SUMMARYThe existence of an immune based graft-versus-leukaemia (GvL) effect highlighted the prospect of managing relapsed leukaemias with T cell-based adoptive immunotherapy. Thus, various strategies have been explored for the in vitro expansion of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ad3108c67455a032281728b5c7a8059
https://doi.org/10.1046/j.1365-2249.2003.02235.x

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Limitations of the use of single base changes in the p53 gene to detect minimal residual disease of breast cancer

Autor: A C Parker, J I O Craig, R C F Leonard, R K B Dang, R S Anthony

Publikováno v: Molecular Pathology. 55:177-181

Background/Aims: Peripheral blood progenitor cell (PBPC) transplantation is frequently used in the treatment of malignant diseases, but contamination of the graft by tumour cells is a real concern and may lead to disease relapse. The feasibility of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f6b8ebf256c183fa556bf0ff734f5b
https://doi.org/10.1136/mp.55.3.177

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Mobilization of MHC class I molecules from late endosomes to the cell surface following activation of CD34-derived human Langerhans cells

Autor: Paul J. Lehner, M. A. Scott, J. P. Luzio, Paul A. MacAry, J. I. O. Craig, Mark E. Lindsay

Publikováno v: Proceedings of the National Academy of Sciences. 98:3982-3987

Langerhans cells are a subset of dendritic cells (DCs) found in the human epidermis with unique morphological and molecular properties that enable their function as “sentinels” of the immune system. DCs are pivotal in the initiation and regulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2588ce449fcebc589cc6caf45f3e5e8e
https://doi.org/10.1073/pnas.071477498

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A comparison of CD34+ cell selected and unselected autologous peripheral blood stem cell transplantation for multiple myeloma: a case controlled analysis

Autor: Robert Marcus, Michael A. Scott, H. K. Jestice, G. Bass, J. I. O. Craig, D. M. Bloxham, Maher K. Gandhi

Publikováno v: Bone Marrow Transplantation. 24:369-375

Following ASCT for multiple myeloma, it is unclear whether relapse is due solely to the presence of residual myeloma cells after myeloablation, or whether it is in part attributable to contamination of the stem cell harvest with viable malignant cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892443fafd075e2ee045caeb25fe70e1
https://doi.org/10.1038/sj.bmt.1701938

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Occupational injury in a fishmonger with a macular rash, hepatosplenomegaly and pancytopenia

Autor: Kristian M. Bowles, J I O Craig, O Sule, L.J. Cooke

Publikováno v: Journal of clinical pathology. 59(9)

A 47-year-old fishmonger presented with a history of weight loss and lethargy. On investigation he was found to have myeloma. He presented again before follow up, with a 3-day history of fever and a maculopapular rash. He was admitted to the haematol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b7f771a5b205de2b540727f92e672c
https://pubmed.ncbi.nlm.nih.gov/16935976

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Synthesis of osteoprotegerin and RANKL by megakaryocytes is modulated by oestrogen

Autor: S, Bord, E, Frith, D C, Ireland, M A, Scott, J I O, Craig, J E, Compston

Publikováno v: British journal of haematology. 126(2)

To investigate the mechanisms by which megakaryocytes (MKs) may influence bone remodelling, CD34(+) cells were cultured for 6, 9 and 12 d with or without 17beta-oestradiol (E) and immunolocalized for osteoprotegerin (OPG), receptor activator of nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2619e0b2fbeea458c435ff4c6cfe3161
https://pubmed.ncbi.nlm.nih.gov/15238146

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Stem cell transplantation after salvage therapy with high-dose cytarabine and amsacrine in adults with high-risk leukaemia

Autor: Gulnaz Begum, Robert Marcus, N Duncan, P Mahendra, Sudhir Tauro, P Shankaranarayana, J. I. O. Craig, I C Nitu-Whalley, Charles Craddock

Publikováno v: Bone marrow transplantation. 32(3)

Stem cell transplantation (SCT) may be the only curative option for patients with relapsed or refractory leukaemia, that is, high-risk (HR) leukaemia. Several salvage regimens have been used to cytoreduce disease before SCT, but disease progression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa0a6cb56e71ec46ff86d90035f7dcf
https://pubmed.ncbi.nlm.nih.gov/12858198

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