Zobrazeno 1 - 10
of 1 217
pro vyhledávání: '"J. Hutter"'
Autor:
G. Ball, S. Oldham, V. Kyriakopoulou, L. Z. J. Williams, V. Karolis, A. Price, J. Hutter, M. L. Seal, A. Alexander-Bloch, J. V. Hajnal, A. D. Edwards, E. C. Robinson, J. Seidlitz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The third trimester of human gestation is characterised by rapid increases in brain volume and cortical surface area. Recent studies have revealed a remarkable molecular diversity across the prenatal cortex but little is known about how this
Externí odkaz:
https://doaj.org/article/0e1b3668e04d419abcc6f7eebfe07e38
Autor:
Sille Remm, Dario De Vecchis, Jendrik Schöppe, Cedric A. J. Hutter, Imre Gonda, Michael Hohl, Simon Newstead, Lars V. Schäfer, Markus A. Seeger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Mycobacterium tuberculosis is protected from antibiotic therapy by a multi-layered hydrophobic cell envelope. Major facilitator superfamily (MFS) transporter Rv1410 and the periplasmic lipoprotein LprG are involved in transport of triacylgly
Externí odkaz:
https://doaj.org/article/1960b492e8a54571b9bda14e84f5dd05
Autor:
Dawid Deneka, Sonja Rutz, Cedric A. J. Hutter, Markus A. Seeger, Marta Sawicka, Raimund Dutzler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Volume-regulated anion channels (VRACs) are heteromers of LRRC8 proteins, all containing the obligatory subunit LRRC8A. Here, the authors develop and characterize nanobodies that bind LRRC8A and allosterically modulate the function of homomeric LRRC8
Externí odkaz:
https://doaj.org/article/4caeef50636c4f189a4fe60799bf32be
Autor:
Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang, Martje Fentener van Vlissingen, Thijs Kuiken, Wenyu Han, Corine H. GeurtsvanKessel, Yuhuan Gong, Yapei Zhao, Quan Shen, Wenming Qin, Xiao-Xu Tian, Chao Peng, Yanling Lai, Yanxing Wang, Cedric A. J. Hutter, Shu-Ming Kuo, Juan Bao, Caixuan Liu, Yifan Wang, Audrey S. Richard, Hervé Raoul, Jiaming Lan, Markus A. Seeger, Yao Cong, Barry Rockx, Gary Wong, Yuhai Bi, Dimitri Lavillette, Dianfan Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here, the authors report the engineering, structural and biological characterization of synthetic nanobodies (sybodies) that display potent therapeutic activity against SARS-CoV-2 infection in animal models via targeting the virus receptor-binding do
Externí odkaz:
https://doaj.org/article/e2d2ef9db7c042d5ae0d4a35e2484adb
Autor:
Gianluca Trinco, Valentina Arkhipova, Alisa A. Garaeva, Cedric A. J. Hutter, Markus A. Seeger, Albert Guskov, Dirk J. Slotboom
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Trinco et al. measure aspartate uptake rates in proteoliposomes containing purified prokaryotic Na+-coupled aspartate transporter GltTk. To overcome limitation of protein orientation, they use synthetic nanobody that blocks transporters from outside
Externí odkaz:
https://doaj.org/article/76bc5140efca4c9482b7af7a5ab080f1
Autor:
Hongmin Cai, Hebang Yao, Tingting Li, Cedric A. J. Hutter, Yanfang Li, Yannan Tang, Markus A. Seeger, Dianfan Li
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-16 (2020)
In this work, the authors demonstrate that a coral thermostable GFP (TGP) is an improved tag compared to conventional GFPs. In addition to reporting melting point stability at temperatures near 90 °C, its fusion also helps increase expression levels
Externí odkaz:
https://doaj.org/article/baab4a34e2bb410bbf23d2caba607e37
Autor:
Cedric A. J. Hutter, M. Hadi Timachi, Lea M. Hürlimann, Iwan Zimmermann, Pascal Egloff, Hendrik Göddeke, Svetlana Kucher, Saša Štefanić, Mikko Karttunen, Lars V. Schäfer, Enrica Bordignon, Markus A. Seeger
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
ABC exporters hydrolyze ATP to pump substrates across membranes, but critical steps of the transport mechanism remain poorly understood. Here, the authors solve the crystal structure of outward-facing TM287/288 with the help of a state-specific sybod
Externí odkaz:
https://doaj.org/article/10e4f9ba103940ba80927107a3cf8a89
Autor:
Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang, Martje Fentener van Vlissingen, Thijs Kuiken, Wenyu Han, Corine H. GeurtsvanKessel, Yuhuan Gong, Yapei Zhao, Quan Shen, Wenming Qin, Xiao-Xu Tian, Chao Peng, Yanling Lai, Yanxing Wang, Cedric A. J. Hutter, Shu-Ming Kuo, Juan Bao, Caixuan Liu, Yifan Wang, Audrey S. Richard, Hervé Raoul, Jiaming Lan, Markus A. Seeger, Yao Cong, Barry Rockx, Gary Wong, Yuhai Bi, Dimitri Lavillette, Dianfan Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/468b30b38fdf49a995f00338e612e44b
Autor:
Kevin Bärlocher, Cedric A. J. Hutter, A. Leoni Swart, Bernhard Steiner, Amanda Welin, Michael Hohl, François Letourneur, Markus A. Seeger, Hubert Hilbi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Legionella pneumophila replicates in a Legionella-containing vacuole (LCV). Here the authors present the structure of the Legionella effector RidL N-terminal domain and reveal how RidL contributes to the subversion of retrograde trafficking by bindin
Externí odkaz:
https://doaj.org/article/148a39307e6a423aa3dcf97540bed38e
Autor:
Christiane Kruppa, Danial J Hutter, Matthias Königshausen, Jan Gessmann, Thomas A Schildhauer, Marlon O Coulibaly
Publikováno v:
SAGE Open Medicine, Vol 7 (2019)
Background and Aims: Radical surgical intervention is necessary to save patients’ lives in cases of necrotizing fasciitis. This leads to persistent disabilities and most likely to a deteriorated quality of life. The purpose of this study was to eva
Externí odkaz:
https://doaj.org/article/4844fb8be0ed437b9d2ed1d91013b592