Zobrazeno 1 - 10
of 364
pro vyhledávání: '"J. Hoenderop"'
Autor:
Willem Bosman, Gijs A. C. Franken, Javier de las Heras, Leire Madariaga, Tahsin Stefan Barakat, Rianne Oostenbrink, Marjon van Slegtenhorst, Ana Perdomo-Ramírez, Félix Claverie-Martín, Albertien M. van Eerde, Rosa Vargas-Poussou, Laurence Derain Dubourg, Irene González-Recio, Luis Alfonso Martínez-Cruz, Jeroen H. F. de Baaij, Joost G. J. Hoenderop
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Variants in the CNNM2 gene are causative for hypomagnesaemia, seizures and intellectual disability, although the phenotypes can be variable. This study aims to understand the genotype–phenotype relationship in affected individuals with CNN
Externí odkaz:
https://doaj.org/article/5f5146f8f8c742b290ce015d63777a81
Autor:
Wouter H. vanMegen, Teun J. vanHoutert, Caro Bos, Dorien J. M. Peters, Jeroen H. F. deBaaij, Joost G. J. Hoenderop
Publikováno v:
Physiological Reports, Vol 12, Iss 7, Pp n/a-n/a (2024)
Abstract Mutations in PKD1 and PKD2 cause autosomal dominant polycystic kidney disease (ADPKD), which is characterized by the formation of fluid‐filled cysts in the kidney. In a subset of ADPKD patients, reduced blood calcium (Ca2+) and magnesium (
Externí odkaz:
https://doaj.org/article/eba8173c9eea463d8246e51aca8aa886
Autor:
Lisanne M. M. Gommers, Pieter A. Leermakers, Jenny van der Wijst, Sara R. Roig, Anastasia Adella, Melissa A. E. van de Wal, René J. M. Bindels, Jeroen H. F. de Baaij, Joost G. J. Hoenderop
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Digestion of dietary fibers by gut bacteria has been shown to stimulate intestinal mineral absorption [e.g., calcium (Ca2+) and magnesium (Mg2+)]. Although it has been suggested that local pH and short-chain fatty acid (SCFA) concentrations
Externí odkaz:
https://doaj.org/article/9d03c143298747c499e96a31f9d2af42
Autor:
Barnabas P. Ilenwabor, Heidi Schigt, Andreas Kompatscher, Caro Bos, Malou Zuidscherwoude, Bram C. J. van der Eerden, Joost G. J. Hoenderop, Jeroen H. F. de Baaij
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Autosomal dominant mutations in FAM111A are causative for Kenny-Caffey syndrome type 2. Patients with Kenny-Caffey syndrome suffer from severe growth retardation, skeletal dysplasia, hypoparathyroidism, hypocalcaemia, hyperphosphataemia and
Externí odkaz:
https://doaj.org/article/6bb0d67424d841f29a387deff5e3e7ee
Autor:
Valentina Carotti, Jenny van der Wijst, Eric H. J. Verschuren, Luco Rutten, Nico Sommerdijk, Charlotte Kaffa, Vera Sommers, Juan P. Rigalli, Joost G. J. Hoenderop
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited disorder characterized by the development of renal cysts, which frequently leads to renal failure. Hypertension and other cardiovascular symptoms contribute to the high morbidity an
Externí odkaz:
https://doaj.org/article/5502d777b83a4e51954e3c5d9191c76c
Autor:
Lynette J. Oost, Steef Kurstjens, Chao Ma, Joost G. J. Hoenderop, Cees J. Tack, Jeroen H. F. de Baaij
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
BackgroundType 2 diabetes (T2D) is characterized by a decreased insulin sensitivity. Magnesium (Mg2+) deficiency is common in people with T2D. However, the molecular consequences of low Mg2+ levels on insulin sensitivity and glucose handling have not
Externí odkaz:
https://doaj.org/article/6c440149b74544d99bec8ba9728b25f2
Autor:
Gijs A. C. Franken, Murat Seker, Caro Bos, Laura A. H. Siemons, Bram C. J. van der Eerden, Annabel Christ, Joost G. J. Hoenderop, René J. M. Bindels, Dominik Müller, Tilman Breiderhoff, Jeroen H. F. de Baaij
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Patients with mutations in Cyclin M2 (CNNM2) suffer from hypomagnesaemia, seizures, and intellectual disability. Although the molecular function of CNNM2 is under debate, the protein is considered essential for renal Mg2+ reabsorption. Here,
Externí odkaz:
https://doaj.org/article/425e0fafae4846bc82edea83d0b50985
Autor:
Anique D. ter Braake, Larissa P. Govers, Mieke J. Peeters, Arjan D. van Zuilen, Jack F. M. Wetzels, Peter J. Blankenstijn, Joost G. J. Hoenderop, Jeroen H. F. de Baaij, Jan A. J. G. van den Brand, For the MASTERPLAN study group
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Higher plasma magnesium concentrations are associated with reduced cardiovascular disease risk in chronic kidney disease (CKD) patients. The importance of plasma magnesium concentration for vascular calcification in earlier stages
Externí odkaz:
https://doaj.org/article/3d4b0043b4c14f32ae5e3f74974584aa
Autor:
Zhiyong Bai, Jianlin Feng, Gijs A C Franken, Namariq Al'Saadi, Na Cai, Albert S Yu, Liping Lou, Yuko Komiya, Joost G J Hoenderop, Jeroen H F de Baaij, Lixia Yue, Loren W Runnels
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001496 (2021)
Magnesium is essential for cellular life, but how it is homeostatically controlled still remains poorly understood. Here, we report that members of CNNM family, which have been controversially implicated in both cellular Mg2+ influx and efflux, selec
Externí odkaz:
https://doaj.org/article/c76f039619694363a455a55068dbbbf7
Autor:
D. H. J. Thijssen, M. T. E. Hopman, M. T. van Wijngaarden, J. G. J. Hoenderop, R. J. M. Bindels, T. M. H. Eijsvogels
Publikováno v:
BMC Medical Education, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background A potential concern of formative testing using web-based applications (“apps”) is provision of limited feedback. Adopting a randomised controlled trial in 463 first year (bio) medical students, we explored if providing immedia
Externí odkaz:
https://doaj.org/article/2670e42525b4431b8e668c270a5263ea