Zobrazeno 1 - 10
of 191
pro vyhledávání: '"J. Hodgins"'
Autor:
Mayra Cruz Tleugabulova, Sandra P. Melo, Aaron Wong, Alexander Arlantico, Meizi Liu, Joshua D. Webster, Julia Lau, Antonie Lechner, Basak Corak, Jonathan J. Hodgins, Venkata S. Garlapati, Marco De Simone, Ben Korin, Shimrit Avraham, Jessica Lund, Surinder Jeet, Alexander Reiss, Hannah Bender, Cary D. Austin, Spyros Darmanis, Zora Modrusan, Hans Brightbill, Steffen Durinck, Michael S. Diamond, Christoph Schneider, Andrey S. Shaw, Maximilian Nitschké
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Macrophages are pleiotropic and diverse cells that populate all tissues of the body. Besides tissue-specific resident macrophages such as alveolar macrophages, Kupffer cells, and microglia, multiple organs harbor at least two subtypes of oth
Externí odkaz:
https://doaj.org/article/8c774d5b94e343909907863638161289
Autor:
John Abou-Hamad, Jonathan J. Hodgins, Edward Yakubovich, Barbara C. Vanderhyden, Michele Ardolino, Luc A. Sabourin
Publikováno v:
Cells, Vol 13, Iss 1, p 73 (2023)
Targeted therapy resistance frequently develops in melanoma due to intratumor heterogeneity and epigenetic reprogramming. This also typically induces cross-resistance to immunotherapies. Whether this includes additional modes of therapy has not been
Externí odkaz:
https://doaj.org/article/379f6adab2d44074b070f701d04bf5df
Autor:
John Abou-Hamad, Jonathan J. Hodgins, Christiano T. de Souza, Brennan Garland, Cédrik Labrèche, Marie Marotel, Cameron Gibson, Samuel Delisle, Julia Pascoal, Rebecca C. Auer, Michele Ardolino, Luc A. Sabourin
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105524- (2022)
Summary: SOX10 is a key regulator of melanoma progression and promotes a melanocytic/differentiated state. Here we identified melanoma cell lines lacking SOX10 expression which retain their in vivo growth capabilities. More importantly, we find that
Externí odkaz:
https://doaj.org/article/627ac5f7b4ef457cb4fd187908d34dd8
Autor:
Jonathan J. Hodgins, John Abou-Hamad, Ash Hagerman, Edward Yakubovich, Christiano Tanese de Souza, Marie Marotel, Ariel Buchler, Saleh Fadel, Maria M. Park, Claire Fong-McMaster, Mathieu F. Crupi, John C. Bell, Mary-Ellen Harper, Benjamin H. Rotstein, Rebecca C. Auer, Barbara C. Vanderhyden, Luc A. Sabourin, Marie-Claude Bourgeois-Daigneault, David P. Cook, Michele Ardolino
Targeting the PD-1/PD-L1 axis has transformed the field of immune-oncology. While conventional wisdom initially postulated that PD-L1 serves as the inert ligand for PD-1, an emerging body of literature suggests that PD-L1 has cell-intrinsic functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1a75c947049681a8f0fcf1c901c4543
https://doi.org/10.1101/2022.08.31.506095
https://doi.org/10.1101/2022.08.31.506095
Akademický článek
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Autor:
Jonathan J. Hodgins, David P. Cook, Cédrik Labrèche, Benjamin R. Pryce, Michele Ardolino, John Abou-Hamad, Pascale Robineau-Charette, Luc A. Sabourin, Barbara C. Vanderhyden, Khalid N. Al-Zahrani, Rebecca C. Auer, John C. Bell, Christiano Tanese de Souza
Publikováno v:
Oncogene. 39:4592-4602
HER2 is overexpressed in 20–30% of all breast cancers and is associated with an invasive disease and poor clinical outcome. The Ste20-like kinase (SLK) is activated downstream of HER2/Neu and is required for efficient epithelial-to-mesenchymal tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cc4676984bf021acddb906daf74fe3e
https://doi.org/10.1038/s41388-020-1315-3
https://doi.org/10.1038/s41388-020-1315-3
Autor:
Mohamed S. Hasim, Marie Marotel, Jonathan J. Hodgins, Elisabetta Vulpis, Olivia J. Makinson, Sara Asif, Han-Yun Shih, Amit K. Scheer, Olivia MacMillan, Felipe G. Alonso, Kelly P. Burke, David P. Cook, Rui Li, Maria Teresa Petrucci, Angela Santoni, Padraic G. Fallon, Arlene H. Sharpe, Giuseppe Sciumè, André Veillette, Alessandra Zingoni, Douglas A. Gray, Arleigh McCurdy, Michele Ardolino
Trogocytosis modulates immune responses, with still unclear underlying molecular mechanisms. Using leukemia mouse models, we found that lymphocytes perform trogocytosis at high rates with tumor cells. While performing trogocytosis, both Natural Kille
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2730a496530c215b2016d185c70d05
http://hdl.handle.net/11573/1633234
http://hdl.handle.net/11573/1633234
Autor:
Marilyn J Hodgins
Publikováno v:
Pain Research and Management, Vol 7, Iss 4, Pp 192-198 (2002)
Poor pain management practices are generally discussed in terms of barriers associated with the patient, clinician and/or health care organization. The impact of deficiencies in the tools that are used to measure pain are seldom addressed. Three fact
Externí odkaz:
https://doaj.org/article/4d43038e99444c4a8ac95e5b6d6106e1
Publikováno v:
Forum: Qualitative Social Research, Vol 15, Iss 1 (2013)
This article is deliberately unconventional in style and reflects a conversation between us—Katherine, senior scientist/principal investigator and Michael, research coordinator—as we embark on an arts-based health research study to explore the th
Externí odkaz:
https://doaj.org/article/22c644afc4d34681b21ce7c9ff199ad0
Autor:
Cédrik Labrèche, Jérôme Frenette, Luc A. Sabourin, Benjamin R. Pryce, John Abou-Hamad, Antoine Boulanger-Piette, Dounia Hamoudi, Khalid N. Al-Zahrani, Cindy Balog-Alvarez, Jonathan J. Hodgins, Michele Ardolino, Sabrina Bossé, Joe N. Kornegay
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1868(2)
Duchenne's muscular dystrophy (DMD) is a severe muscle wasting disorder characterized by the loss of dystrophin expression, muscle necrosis, inflammation and fibrosis. Ongoing muscle regeneration is impaired by persistent cytokine stress, further dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc31a1dfee7cad418cf3c6ffc0a678a5
https://pubmed.ncbi.nlm.nih.gov/33259860
https://pubmed.ncbi.nlm.nih.gov/33259860