Zobrazeno 1 - 10
of 292
pro vyhledávání: '"J. Hindley"'
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary tables 1-6 summarise the kinase panel screen data (1) mouse PK parameters (2) and further details of the anti-tumour activity (5) conferred by ASTX029, plus details of cell lines used in this study (3 and 4) and further details of the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c83a97aa3dd2ed35fbdc9ef36e9bb5
https://doi.org/10.1158/1535-7163.22521489.v1
https://doi.org/10.1158/1535-7163.22521489.v1
Autor:
Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
Supplementary figures 1-7 show the effects of AST029 on ERK signalling in RAS-mutant cell lines (1) and tumour xenograft tissue (3), ASTX029 plasma PK linearity (2), ASTX029 activity in a cell line panel showing MAPK mutation status (4) the effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185aef78c19fca4a606a8b2c178f1341
https://doi.org/10.1158/1535-7163.22521498.v1
https://doi.org/10.1158/1535-7163.22521498.v1
Autor:
Neil T. Thompson, Nicola G. Wallis, Michael Reader, Christopher J. Hindley, Juan Castro, John Lyons, David C. Rees, Nicola E. Wilsher, Caroline Richardson, Tom D. Heightman, Lukas Stanczuk, Alpesh Shah, Sharna J. Rich, Charlotte East, Valerio Berdini, Marc O'Reilly, Justyna Kucia-Tran, Jessica L. Brothwood, Joanne M. Munck, Alison Jo-Anne Woolford, Sandra Muench, Christopher William Murray, David Norton, Luke Bevan, Aurélie Courtin, Roberta Ferraldeschi, Vanessa Martins
Publikováno v:
Molecular Cancer Therapeutics. 20:1757-1768
The MAPK signaling pathway is commonly upregulated in human cancers. As the primary downstream effector of the MAPK pathway, ERK is an attractive therapeutic target for the treatment of MAPK-activated cancers and for overcoming resistance to upstream
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6856599564530823950e091fd6e69a67
https://doi.org/10.1158/1535-7163.mct-20-0909
https://doi.org/10.1158/1535-7163.mct-20-0909
Autor:
Priyanka Sharma, Sujan Piya, Natalia Baran, Anna Zal, Christopher J. Hindley, Kim-Hien Dao, Martin Sims, Tomasz Zal, Vivian Ruvolo, Michael Andreeff, Gautam Borthakur
Publikováno v:
Blood. 140:8789-8790
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36362595358119339c3857b37fb38bfe
https://doi.org/10.1182/blood-2022-167171
https://doi.org/10.1182/blood-2022-167171
Autor:
Priyanka Sharma, Sujan Piya, Natalia Baran, Muharrem Muftuoglu, Mahesh Basyal, Vivian Ruvolo, Christopher J. Hindley, Kim-Hien Dao, Martin Sims, Michael Andreeff, Gautam Borthakur
Publikováno v:
Blood. 140:3093-3094
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a95b532b2dcce48d93a5ebd1abb1ad49
https://doi.org/10.1182/blood-2022-165552
https://doi.org/10.1182/blood-2022-165552
Autor:
J, Zimmer, S, Schmidt, A, Costanzo, K-H, Buchheit, S, Brown, J, Carnés, M, Chapman, A, Chen, M, De Neergaard, S, Döring, J, Hindley, T, Holzhauser, S, Jorajuria, D, Le Tallec, M, Lombardero, P, Iacovacci, G, Reese, I, Sander, B, Smith, D, Strecker, R, van Ree, M, Zebina, S, Kaul, S, Vieths
Publikováno v:
Pharmeuropa bio & scientific notes, 2022, 55-86. European Directorate for the Quality of Medicines
Progress towards standardisation of allergen products has been made in recent years. Nevertheless, no standardised test method to quantify the allergen content of grass pollen allergen products is available at present. One aim of the BSP090 project w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c4531401aad06ce0be3c1b82285e3331
https://pure.amc.nl/en/publications/validation-of-an-elisa-method-for-quantification-of-the-major-timothy-grass-pollen-allergen-phl-p-5a-bsp090(4568e494-49ff-4d15-8560-413a65d1ab85).html
https://pure.amc.nl/en/publications/validation-of-an-elisa-method-for-quantification-of-the-major-timothy-grass-pollen-allergen-phl-p-5a-bsp090(4568e494-49ff-4d15-8560-413a65d1ab85).html
Autor:
Paula A. Coelho, Leah Bury, Marta N. Shahbazi, Kifayathullah Liakath-Ali, Peri H. Tate, Sam Wormald, Christopher J. Hindley, Meritxell Huch, Joy Archer, William C. Skarnes, Magdalena Zernicka-Goetz, David M. Glover
Publikováno v:
Open Biology, Vol 5, Iss 12 (2015)
To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4). Over-expression o
Externí odkaz:
https://doaj.org/article/fb7c55753275446ca4fbdadbb39cc1e2
Autor:
Gizem Turaç, Christopher J Hindley, Ria Thomas, Jason A Davis, Michela Deleidi, Thomas Gasser, Erdal Karaöz, Jan Pruszak
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68519 (2013)
Surface molecule profiles undergo dynamic changes in physiology and pathology, serve as markers of cellular state and phenotype and can be exploited for cell selection strategies and diagnostics. The isolation of well-defined cell subsets is needed f
Externí odkaz:
https://doaj.org/article/7c077d623252447b98ab32840b7ba13c
Autor:
Inigo Martincorena, Robert Arnes-Benito, Nicole Prior, Brigitte Angres, Alex Cagan, Natasha Ivory, Benjamin D. Simons, Gianmarco Mastrogiovanni, Siong-Seng Liau, Christopher J. Hindley, Nikitas Georgakopoulos, Kourosh Saeb-Parsy, Helmut Wurst, Abbie Curd, Meritxell Huch, Daisy Harrison
Publikováno v:
BMC Developmental Biology
BMC Developmental Biology, Vol 20, Iss 1, Pp 1-20 (2020)
BMC Developmental Biology, Vol 20, Iss 1, Pp 1-20 (2020)
Background Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while previously reported human pancreas o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613b1070e7fcc2030bc6c6f49a93e7b6
https://www.repository.cam.ac.uk/handle/1810/306332
https://www.repository.cam.ac.uk/handle/1810/306332
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