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MUC1 (episialin) expression in non-small cell lung cancer is independent of EGFR and c-erbB-2 expression and correlates with poor survival in node positive patients

Autor: A.M. Vignola, Alexandra Giatromanolaki, C. Reina, F. Guddo, M I Koukourakis, Adrian L. Harris, Gregory Chlouverakis, G. Bonsignore, J Hilkens, K C Gatter

Publikováno v: Scopus-Elsevier

AIM: To examine tumour samples immunohistochemically for MUC1 (episialin), epidermal growth factor receptor (EGFR), and c-erbB-2, since the disruption of the cell-cell adhesion system by MUC1 and the c-erbB oncoprotein family is known to be important

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbceae628c3a2c16a054d4b96f9ebc5
https://doi.org/10.1136/jcp.51.9.667

Carcinoma-associated monoclonal antibodies in head and neck carcinoma

Autor: Alfons J. M. Balm, J. Hilkens, C. L. Mulder, P. C. Hageman

Publikováno v: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS), 249(5), 237-242. Springer Verlag

Monoclonal antibodies (mAbs) 175F4 (IgG1) and 175F11 (IgG2a), originally raised against the human mammary carcinoma cell line (ZR-75-1), react with a carcinoma-associated antigen in both adenocarcinomas and squamous cell carcinomas of different origi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4276ac643c3422d71b9a8fdad3c55a72
https://doi.org/10.1007/bf00714484

The epithelial sialomucin, episialin, is sialylated during recycling

Autor: S V, Litvinov, J, Hilkens

Publikováno v: The Journal of biological chemistry. 268(28)

Episialin, the sialomucin encoded by the MUC1 gene is abundantly present at the surface of various epithelial cells. It is a transmembrane molecule that matures through several intermediate forms generated by proteolysis and sequential addition and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7dc92799d6d984da5ab8fd66e4c284fd
https://pubmed.ncbi.nlm.nih.gov/8407976

Suppression of cellular aggregation by high levels of episialin

Autor: M J, Ligtenberg, F, Buijs, H L, Vos, J, Hilkens

Publikováno v: Cancer research. 52(8)

Episialin is a mucin-like molecule located at the apical surface of most glandular epithelial cells. It is present at increased levels in carcinomas, where the molecule is often distributed over the entire cell surface. We have simulated this overpro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4f9697343e3882440d6e89d91d83ceff
https://pubmed.ncbi.nlm.nih.gov/1559234