Zobrazeno 1 - 10
of 393
pro vyhledávání: '"J. Heykants"'
Autor:
J. Van Houdt, J. Heykants, V Van Genechten, K. Lavrijsen, Peter Verboven, J. Hendrickx, Hilde Bohets, Willem Meuldermans
Publikováno v:
British Journal of Pharmacology. 129:1655-1667
Cisapride is a prokinetic drug that is widely used to facilitate gastrointestinal tract motility. Structurally, cisapride is a substituted piperidinyl benzamide that interacts with 5-hydroxytryptamine-4 receptors and which is largely without central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c872e9987f893b5fd62ba4ca8da6e058
https://doi.org/10.1038/sj.bjp.0703246
https://doi.org/10.1038/sj.bjp.0703246
Autor:
A. Van Peer, E. Snoeck, Meindert Danhof, V. Piotrovskij, J. Heykants, R L Lins, P. Jacqmin, A G Dupont, R. Van Gool, Robert Woestenborghs
Publikováno v:
European journal of clinical pharmacology
Vrije Universiteit Brussel
Vrije Universiteit Brussel
Objective: The pharmacokinetics and non-linear red blood cell partitioning of the nucleoside transport inhibitor draflazine were investigated in 19 healthy male and female subjects (age range 22–55 years) after a 15-min i.v. infusion of 1 mg, immed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2212a82e6550b26a52eb6dc042210953
https://doi.org/10.1007/s002280050337
https://doi.org/10.1007/s002280050337
Autor:
R. Woestenborghs, E. Snoeck, R. Van Gool, H. Van Belle, Meindert Danhof, P. Jacqmin, J. Heykants, R. Crabbé, A. Dupont, K. Ver Donck, A. Van Peer
Publikováno v:
Vrije Universiteit Brussel
1. Draflazine, a nucleoside transport inhibitor, was administered as a 15 min i.v. infusion of 2.5 mg to eight healthy male subjects. Plasma and whole blood concentrations were measured up to 32 h post-dose, and were related to adenosine breakdown in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275407691d0658d4d53df22ed4b345ca
https://doi.org/10.1111/j.1365-2125.1996.tb00116.x
https://doi.org/10.1111/j.1365-2125.1996.tb00116.x
Autor:
C. Borgmans, Marc Bockx, Willem Meuldermans, C. Zwijsen, Geert Mannens, J. Hendrickx, J. Heykants
Publikováno v:
Journal of Chromatography A. 729:341-354
Nebivolol hydrochloride (R067555), is a new antihypertensive drug. Aromatic and alicyclic hydroxylation at the benzopyran ring systems of nebivolol are important metabolic pathways. Generally, NMR is used to unambiguously assign the sites of hydroxyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5abe84263f01cf7e70e6becc7e1d39c
https://doi.org/10.1016/0021-9673(95)01114-5
https://doi.org/10.1016/0021-9673(95)01114-5
Autor:
Willem Meuldermans, Rita J. F. Geerts, Ludy van Beijsterveldt, Anton Megens, Josée E. Leysen, Hilde M. J. Van den Eynde, J. Heykants
Publikováno v:
Psychopharmacology. 114:53-62
Risperidone is a new benzisoxazole antipsychotic. 9-Hydroxy-risperidone is the major plasma metabolite of risperidone. The pharmacological properties of 9-hydroxy-risperidone were studied and appeared to be comparable to those of risperidone itself,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44378fab90f2b3b5a5362c8cfc991c17
https://doi.org/10.1007/bf02245444
https://doi.org/10.1007/bf02245444
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:2224-2227
Pharmacologic studies of itraconazole (IZ), a triazole antifungal, indicated unexplained differences between bioassay and chromatographic determinations and large variations in steady-state blood concentrations. We show that concentrations of a hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d90080efb4ff120a640dea505f63c51
https://doi.org/10.1128/aac.37.10.2224
https://doi.org/10.1128/aac.37.10.2224
Autor:
M. M. Klauw, B. H. Ch. Stricker, J. P. Ottervanger, F. G. A. Meché, J. M. T. Griensven, H. H. P. J. Lemkes, J. M. Kroon, H. C. Schoemaker, A. F. Cohen, J. H. M. Schellens, W. Loos, B. Acker, M. Boer-Dennert, A. S. T. Planting, M. E. L. Burg, G. Stoter, R. Krediet, J. Verweij, E. E. Blaak, M. A. Baak, G. J. Kemerink, M. T. W. Pakbiers, G. A. K. Heidendal, W. H. M. Saris, S. Bouckaert, L. Vakaet, M. Dhont, J. P. Remon, S. A. J. Broek, P. A. Graeff, W. H. Gilst, D. J. Veldhuisen, H. L. Hillige, H. Wesseling, K. I. Lie, C. A. Gaillard, P. N. Es, P. W. Leeuw, L. M. A. B. Bortel, M. J. F. Kool, F. A. T. Lustermans, J. G. S. Breed, A. P. G. Hoeks, H. A. J. Struijker Boudier, R. P. Pickkers, P. Smits, H. Baadenhuysen, A. Laar, Th. Thien, M. M. Elseviers, M. E. Broe, A. J. A. M. Ven, P. P. Koopmans, W. H. M. Peters, T. B. Vree, J. W. M. Meer, E. Snoeck, A. Peer, M. Sack, M. Horton, G. Mannens, R. Woestenborghs, J. Heykants, R. Meibach, T. B. Witsen, H. A. Valkenburg, R. H. Stichele, B. Potter, P. Vyncke, M. G. Bogaert, J. Burggraaf, H. Wollersheim, J. Aalen, R. G. Schoemaker, X. Y. Du, W. A. Bax, E. Bos, P. R. Saxena, G. A. Rongen, P. N. M. Heiningen, H. R. Schwietert, J. M. Kortboyer, F. A. E. Sollie, C. Piraube, P. Desché, J. H. G. Jonkman, W. L. Blok, I. C. Gyssens, Y. A. Hekster, P. A. F. Jansen, R. C. Sival, J. F. Nieuwkerk, B. Klaverwiiden, E. A. Bruijn, O. Driessen
Publikováno v:
Pharmacy World & Science. 15:1-7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef2aae6a441771cb628d57e3209c1802
https://doi.org/10.1007/bf01876624
https://doi.org/10.1007/bf01876624
Autor:
M. Ahnoff, D. E. M. M. Vendrig, P. M. Burger, G. P. Kaijser, A. J. Beysens, J. Beer, C. A. Hoefnagel, G. H. Beuman, L. Cornelissen, J. J. Heijden, O. L. T. Hulten, E. C. Voorden, M. P. N. Spruijt, O. M. Steijqer, F. Rompaey, Jos Hoogmartens, P. S. L. Janssen, W. Lorreyne, E. Macken, J. Hoebus, P. Herdewijn, J. Hooqmartens, J. Bosman, P. L. Meenhorst, E. Jeunink, Arthur Van Aerschot, Willy J. M. Underberg, W. Bossche, D. Roosbroeck, A. R. Wafelman, R. A. Zesuw, I. Geuens, E. Porqueras, P. Fluiter, R. A. Zeeuw, E. H. J. M. Jansen, J. Crommen, E. Gout, C. Pauwels, O. Tellingen, J. Hartstra, G. Thoithi, K. Khan, K Ensing, R. Woestenborghs, Eugene Roets, C. Hendrix, Li Ming Yun, D. T. Witte, A. Schepdael, H. Rosing, H. Lingeman, C. H. W. Koks, Jos H. Beijnen, J. Heykants, M. H. J. M. Langenhuizen, Jp Franke, J. Paesen, Zhu Yongxin, R. Gijn, K. E. J. Hoogtanders
Publikováno v:
Pharmacy World amp; Science. 15:B1-B8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4cb574659fa453910bcba614ae6c230
https://doi.org/10.1007/bf01876954
https://doi.org/10.1007/bf01876954
Autor:
Willem Meuldermans, Robert Woestenborghs, Geert Mannens, A. Van Peer, V. Van de Velde, J. Heykants, E. Snoeck
Publikováno v:
Drug Investigation. 3:25-30
Nebivolol is the racemic mixture of 2 isomers with 4 asymmetric centres. The d-isomer has the SRRR configuration, and the l-isomer is RSSS. Animal and human pharmacological experiments demonstrated that the antihypertensive and haemodynamic action of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223a8f16f0e40085f81e81971d775a90
https://doi.org/10.1007/bf03258259
https://doi.org/10.1007/bf03258259
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:402-408
The induction of drug-metabolizing enzymes in rat liver was studied after subchronic administration of the new triazole antifungal agent fluconazole. The administered doses were 10, 40, and 160 mg/kg per day for 7 days. Fluconazole behaved as a high-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b16276f0e99b420155ceab0e0fbc0a
https://doi.org/10.1128/aac.34.3.402
https://doi.org/10.1128/aac.34.3.402