Zobrazeno 1 - 10
of 107
pro vyhledávání: '"J. Hervieu"'
Autor:
Alison I. Muir, Shelagh Wilson, Christopher N. Johnson, Kim Winborn, Alex J. Stevens, Guillaume J. Hervieu, Peter J. O'Hanlon, Phillip Jeffrey, John H. Bateson, Kevin M. Thewlis, David R. Witty, Geoffrey Stemp
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4865-4871
We report here the discovery of a class of MCH R1 ligands based on a biphenyl carboxamide template. A docked-in model is presented indicating key interactions in the putative binding site of the receptor. Parallel high throughput synthetic techniques
Autor:
Guillaume J. Hervieu
Publikováno v:
Expert Opinion on Therapeutic Targets. 10:211-229
Melanin-concentrating hormone (MCH) is a critical hypothalamic anabolic neuropeptide, with key central and peripheral actions on energy balance regulation. The actions of MCH are, so far, known to be transduced through two seven-transmembrane-like re
Autor:
A. J. Hunter, Jane E. Cluderay, J. Latcham, Christian Heidbreder, Pippa L Pugh, Jon T. Brown, Charlie Reavill, Lee A. Dawson, Ceri H. Davies, Evelyn Grau, Susan J. Pickering, G Brown, Claire S. Shilliam, Barry Crook, A Howarth, Panida Hemmati, Zoe A. Hughes, Derek C. Rogers, Guillaume J. Hervieu, Stephen M. Harrison, Peter R. Maycox
Publikováno v:
Molecular and Cellular Neuroscience. 24:1170-1179
Several psychiatric diseases, including schizophrenia, are thought to have a developmental aetiology, but to date no clear link has been made between psychiatric disease and a specific developmental process. LPA1 is a Gi-coupled seven transmembrane r
Autor:
Guillaume J. Hervieu
Publikováno v:
Expert Opinion on Therapeutic Targets. 7:495-511
Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, which centrally regulates food intake and stress. MCH induces food intake in rodents and, more generally, acts as an anabolic signal in energy regulation. In addition, MCH seems to be acti
Autor:
Jeannie Todd, G. Riley, Shelagh Wilson, A Kennedy, M. Jones, David R. Witty, Guillaume J. Hervieu, Stephen R. Bloom, K. Winborne, Waljit S. Dhillo, M. A. Ghatei, C. P. O'Toole, L. J. Seal
Publikováno v:
Journal of Neuroendocrinology. 15:268-272
Melanin-concentrating hormone (MCH) is implicated in the control of a number of hormonal axes including the hypothalamic-pituitary adrenal (HPA) axis. Previous studies have shown that there is evidence for both a stimulatory and an inhibitory action
Publikováno v:
European Journal of Neuroscience. 15:315-328
The neuropeptides orexin-A and orexin-B are produced in neurons of the lateral hypothalamic area and have been implicated to be involved in the regulation of food/water intake and sleep-wake control. The orexins act at two different G-protein-coupled
Autor:
J. Meakin, D.C Harrison, P. Maycox, J. E. Cluderay, Guillaume J. Hervieu, R. A. Leslie, S. Nasir
Publikováno v:
European Journal of Neuroscience. 12:1194-1216
Melanin-concentrating hormone (MCH), a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus. It is implicated in the control of general arousal and goal-orientated behaviours in mammals, and appears to be a key messenger in the regu
Autor:
Barbara Beckmann, Guillaume J Hervieu, Marcus Schindler, Gisela Segond von Banchet, Bernd Heppelmann, Piers C. Emson
Publikováno v:
Brain Research. 816:254-257
Using gold-labelled somatostatin, somatostatin binding sites were predominantly found in laminae I–III, X and on motorneurones of the rat lumbar spinal cord. A comparison with immunohistochemical staining using antisera against somatostatin recepto
Publikováno v:
Animal Feed Science and Technology
Animal Feed Science and Technology, Elsevier Masson, 1996, pp.267-282
Animal Feed Science and Technology, Elsevier Masson, 1996, pp.267-282
The effects on ruminal characteristics of 14 diets differing in nature and level of roughage and concentrate have been studied. The roughages were alfalfa hay (AH) or maize stover silage (MS) distributed alone or in a mixed diet containing 30 or 60%
Publikováno v:
Small Ruminant Research. 19:23-28
Effects of 5 mg estradiol-17β plus 30 mg trenbolone acetate on growth, N retention, and urea metabolism were studied in eight control and eight male goat kids implanted at 21 days of age and hand-fed milk. N balance was measured over a 5 day period