Zobrazeno 1 - 10
of 290
pro vyhledávání: '"J. Hergenrother"'
Autor:
Amanda J. Smith, Paul J. Hergenrother
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Chemical inducers of apoptosis have been utilized for decades as tools to uncover steps of the apoptotic cascade and to treat various diseases, most notably cancer. While there are several useful compounds available, limitations in potency,
Externí odkaz:
https://doaj.org/article/32c1cb85de57428ebe044506d28ada6b
Autor:
Adrián González-López, Daniel S. D. Larsson, Ravi Kiran Koripella, Brett N. Cain, Martin Garcia Chavez, Paul J. Hergenrother, Suparna Sanyal, Maria Selmer
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The antibiotic fusidic acid (FA) is used to treat Staphylococcus aureus infections. It inhibits protein synthesis by binding to elongation factor G (EF-G) and preventing its release from the ribosome after translocation. While FA, due to per
Externí odkaz:
https://doaj.org/article/688e7a88add545d890d90508e053347f
Autor:
Brett N. Cain, Paul J. Hergenrother
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 3, Pp n/a-n/a (2024)
Externí odkaz:
https://doaj.org/article/7cd0bab23ae44f5691a1b6987002c689
Autor:
David M Kranz, Edward J Roy, Preeti Sharma, Diana Rose E Ranoa, Claire P Schane, Amber N Lewis, Edward Valdez, Venkata V V R Marada, Marlies V Hager, Will Montgomery, Steven P Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M Fan, Paul J Hergenrother
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Treatment of some blood cancers with T cells that express a chimeric antigen receptor (CAR) against CD19 have shown remarkable results. In contrast, CAR-T cell efficacy against solid tumors has been difficult to achieve.Methods To examine
Externí odkaz:
https://doaj.org/article/861817e037174ed8a392e07d910f8aaf
Autor:
Jiangwei Wang, Xiaolin Su, Lingxiang Jiang, Matthew W. Boudreau, Lindsay E. Chatkewitz, Jessica A. Kilgore, Kashif Rafiq Zahid, Noelle S. Williams, Yaomin Chen, Shaohui Liu, Paul J. Hergenrother, Xiumei Huang
Publikováno v:
Cancers, Vol 15, Iss 24, p 5844 (2023)
Lung and breast cancers rank as two of the most common and lethal tumors, accounting for a substantial number of cancer-related deaths worldwide. While the past two decades have witnessed promising progress in tumor therapy, developing targeted tumor
Externí odkaz:
https://doaj.org/article/e68fc5c06b6b49fc825f9ed81528a168
Autor:
Diana Rose E. Ranoa, Robin L. Holland, Fadi G. Alnaji, Kelsie J. Green, Leyi Wang, Richard L. Fredrickson, Tong Wang, George N. Wong, Johnny Uelmen, Sergei Maslov, Zachary J. Weiner, Alexei V. Tkachenko, Hantao Zhang, Zhiru Liu, Ahmed Ibrahim, Sanjay J. Patel, John M. Paul, Nickolas P. Vance, Joseph G. Gulick, Sandeep Puthanveetil Satheesan, Isaac J. Galvan, Andrew Miller, Joseph Grohens, Todd J. Nelson, Mary P. Stevens, P Mark Hennessy, Robert C. Parker, Edward Santos, Charles Brackett, Julie D. Steinman, Melvin R. Fenner, Kirstin Dohrer, Michael DeLorenzo, Laura Wilhelm-Barr, Brian R. Brauer, Catherine Best-Popescu, Gary Durack, Nathan Wetter, David M. Kranz, Jessica Breitbarth, Charlie Simpson, Julie A. Pryde, Robin N. Kaler, Chris Harris, Allison C. Vance, Jodi L. Silotto, Mark Johnson, Enrique Andres Valera, Patricia K. Anton, Lowa Mwilambwe, Stephen P. Bryan, Deborah S. Stone, Danita B. Young, Wanda E. Ward, John Lantz, John A. Vozenilek, Rashid Bashir, Jeffrey S. Moore, Mayank Garg, Julian C. Cooper, Gillian Snyder, Michelle H. Lore, Dustin L. Yocum, Neal J. Cohen, Jan E. Novakofski, Melanie J. Loots, Randy L. Ballard, Mark Band, Kayla M. Banks, Joseph D. Barnes, Iuliana Bentea, Jessica Black, Jeremy Busch, Abigail Conte, Madison Conte, Michael Curry, Jennifer Eardley, April Edwards, Therese Eggett, Judes Fleurimont, Delaney Foster, Bruce W. Fouke, Nicholas Gallagher, Nicole Gastala, Scott A. Genung, Declan Glueck, Brittani Gray, Andrew Greta, Robert M. Healy, Ashley Hetrick, Arianna A. Holterman, Nahed Ismail, Ian Jasenof, Patrick Kelly, Aaron Kielbasa, Teresa Kiesel, Lorenzo M. Kindle, Rhonda L. Lipking, Yukari C. Manabe, Jade ́ Mayes, Reubin McGuffin, Kenton G. McHenry, Agha Mirza, Jada Moseley, Heba H. Mostafa, Melody Mumford, Kathleen Munoz, Arika D. Murray, Moira Nolan, Nil A. Parikh, Andrew Pekosz, Janna Pflugmacher, Janise M. Phillips, Collin Pitts, Mark C. Potter, James Quisenberry, Janelle Rear, Matthew L. Robinson, Edith Rosillo, Leslie N. Rye, MaryEllen Sherwood, Anna Simon, Jamie M. Singson, Carly Skadden, Tina H. Skelton, Charlie Smith, Mary Stech, Ryan Thomas, Matthew A. Tomaszewski, Erika A. Tyburski, Scott Vanwingerden, Evette Vlach, Ronald S. Watkins, Karriem Watson, Karen C. White, Timothy L. Killeen, Robert J. Jones, Andreas C. Cangellaris, Susan A. Martinis, Awais Vaid, Christopher B. Brooke, Joseph T. Walsh, Ahmed Elbanna, William C. Sullivan, Rebecca L. Smith, Nigel Goldenfeld, Timothy M. Fan, Paul J. Hergenrother, Martin D. Burke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Safely opening university campuses has been a major challenge during the COVID-19 pandemic. Here, the authors describe a program of public health measures employed at a university in the United States which, combined with other non-pharmaceutical int
Externí odkaz:
https://doaj.org/article/ffcad29e72474331887d87521ba4c4f9
Autor:
Alycen P. Lundberg, Matthew W. Boudreau, Kim A. Selting, Lindsay E. Chatkewitz, Jonathan Samuelson, Joshua M. Francis, Elizabeth I. Parkinson, Anne M. Barger, Paul J. Hergenrother, Timothy M. Fan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 8, Pp 811-822 (2021)
Developing effective therapies for the treatment of advanced head-and-neck squamous cell carcinoma (HNSCC) remains a major challenge, and there is a limited landscape of effective targeted therapies on the horizon. NAD(P)H:quinone oxidoreductase 1 (N
Externí odkaz:
https://doaj.org/article/65baeeaccc594d50a1f1c47686eda0a4
Autor:
Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez, Francesca Maremonti, Florian Gembardt, Nina Himmerkus, Markus Latk, Sophie Locke, Julian Marschner, Wenjun Li, Spencer Short, Sebastian Doll, Irina Ingold, Bettina Proneth, Christoph Daniel, Nazanin Kabgani, Rafael Kramann, Stephen Motika, Paul J. Hergenrother, Stefan R. Bornstein, Christian Hugo, Jan Ulrich Becker, Kerstin Amann, Hans-Joachim Anders, Daniel Kreisel, Derek Pratt, Michael Gütschow, Marcus Conrad, Andreas Linkermann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Necroptosis, a form of cell death, occurs in acute renal injury. Here, the authors show that ferroptosis—a form of cell death dependent on iron - also occurs during acute kidney injury, and show that an inhibitor of ferroptosis can improve survival
Externí odkaz:
https://doaj.org/article/1e6956b0bc82403cacae878852daffc3
Autor:
Ananya Anmangandla, Sadhan Jana, Kewen Peng, Shamar D. Wallace, Saket R. Bagde, Bryon S. Drown, Jiashu Xu, Paul J. Hergenrother, J. Christopher Fromme, Hening Lin
Publikováno v:
ACS Chemical Biology. 18:1200-1207
Autor:
Santanu Ghosh, Rachel Yang, Darjan Duraki, Ji Eun Kim, Junyao Zhu, Mara Livezey, Matthew Boudreau, Ben H. Park, TImothy Fan, Erik R. Nelson, Paul J. Hergenrother, David J. Shapiro
Publikováno v:
Cancer Research. 83:P6-10
Immunotherapy has dramatically impacted cancer therapy, but it has been challenging to apply immunotherapy to estrogen receptor (ER) positive breast cancer and many other solid tumors that do not display neoantigens. One way to target these tumors is