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Viral mimic poly-(IC) attenuates airway epithelial T-cell suppressive capacity:: implications for asthma

Autor: Harold G. de Bruin, Jürgen Schwarze, Maarten van den Berge, Paul M. Fitch, Claire Errington, Reina Matsuda, J. Heimweg, Antoon J. M. van Oosterhout, Irene H. Heijink

Publikováno v: European Respiratory Journal, 48(6), 1785-1788. EUROPEAN RESPIRATORY SOC JOURNALS LTD
Schwarze, J, Fitch, P, Heimweg, J, Errington, C, Matsuda, R, de Bruin, H G, van der Berge, M, van Oosterhout, A J M & Heijink, I H 2016, ' Viral mimic poly-(I:C) attenuates airway epithelial T cell suppressive capacity; implications for asthma ', European Respiratory Journal . https://doi.org/10.1183/13993003.00841-2016

In allergen-sensitised asthmatic individuals, allergen-specific type-2 T-helper cells proliferate and secrete type-2 cytokines (e.g. interleukin (IL)-4, -5 and -13), driving the airway inflammatory response that gives rise to the clinical symptoms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5dfe0c970ebe4c36fb1d1e9185a040
https://research.rug.nl/en/publications/34079217-aa5a-42ee-af00-33789e04d783

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Preeclampsia is Associated with Lower Percentages of Regulatory T Cells in Maternal Blood

Autor: Sicco van der Heide, Jan Jaap H. M. Erwich, Antoon J. M. van Oosterhout, Hendrik M. Boelens, Jelmer R. Prins, J. Heimweg, Anthony E.J. Dubois

Publikováno v: HYPERTENSION IN PREGNANCY, 28(3), 300-311

Objective: Immunological mechanisms are involved in the pathophysiology of preeclampsia. During pregnancy there is an increase in regulatory T (Treg) cells, which has an important role in regulating tolerance to the immunologically distinct fetus. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2667ab0e5b38915ece057c58759bf75
https://doi.org/10.1080/10641950802601237

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Low-dose acarbose does not delay digestion of starch but reduces its bioavailability

Autor: Marion G. Priebe, AM Heiner, J. Heimweg, H Elzinga, Roelf Vonk, Frans Stellaard, RE Wachters-Hagedoorn

Publikováno v: Diabetic Medicine, 24(6), 600-606. Wiley

Aims Slowly digestible starch is associated with beneficial health effects. The glucose-lowering drug acarbose has the potential to retard starch digestion since it inhibits alpha-amylase and alpha-glucosidases. We tested the hypothesis that a low do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f27addb788a48e3a2177c0503cfd5707
https://doi.org/10.1111/j.1464-5491.2007.02115.x

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The Rate of Intestinal Glucose Absorption Is Correlated with Plasma Glucose-Dependent Insulinotropic Polypeptide Concentrations in Healthy Men

Autor: Roel J. Vonk, Klaus N. Englyst, A. Marius Heiner, RE Wachters-Hagedoorn, Jens J. Holst, Marion G. Priebe, J. Heimweg, Frans Stellaard

Publikováno v: The Journal of Nutrition, 136(6), 1511-1516. Oxford University Press

Glucagon-like pepticle-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) both play a role in the control of glucose homeostasis, and GIP is implicated in the regulation of energy storage. The capacity of carbohydrates to induce secreti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ce00935fc8b7a3ea9db0ee805b3a14
https://doi.org/10.1093/jn/136.6.1511

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Cryopreservation does not alter the frequency of regulatory T cells in peripheral blood mononuclear cells

Autor: D. Van Hemelen, Martijn C. Nawijn, J. N. G. Oude Elberink, A. J. M. Van Oosterhout, J. Heimweg

Publikováno v: Journal of Immunological Methods, 353(1-2), 138-140. ELSEVIER SCIENCE BV

Sir,With great interest we read therecentarticle intheJournalof Immunological Methods by Elkord (2009), in which theauthor reports a reduction of human regulatory T (Treg) cellnumbers in peripheral blood mononuclear cells (PBMCs) aftercryopreservatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08abb4dd7be945350cd5f5eaa0e5d03a
https://doi.org/10.1016/j.jim.2009.11.012

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Flow cytometric analysis of cytokine expression in short-term allergen-stimulated T cells mirrors the phenotype of proliferating T cells in long-term cultures

Autor: Martijn C. Nawijn, J. N. G. Oude Elberink, A. J. M. Van Oosterhout, D. Van Hemelen, J. Heimweg, Barbara Bohle

Publikováno v: Journal of Immunological Methods, 371(1-2), 114-121. ELSEVIER SCIENCE BV

Background: Allergen-specific T(H) cells play an important role in IgE-mediated disorders as allergies. Since this T(H) cell-population only accounts for a small percentage of Tv, cells, they are difficult to phenotype without prior selection or expa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f36cf8d9daaa3291449f9ed6a7e4fb
https://pubmed.ncbi.nlm.nih.gov/21741978

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An explorative study of in vivo digestive starch characteristics and postprandial glucose kinetics of wholemeal wheat bread

Autor: Frans Stellaard, Roel J. Vonk, RE Wachters-Hagedoorn, Marion G. Priebe, J. Heimweg, Tom Preston, Alexandra Small, H Elzinga

Publikováno v: European Journal of Nutrition, 47(8), 417-423. SPRINGER HEIDELBERG

Based on in vitro measurements, it is assumed that starch in wholemeal bread is rapidly digestible, which is considered to be less desirable for health.To evaluate the in vitro prediction, we characterized starch digestion of wholemeal wheat bread (W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7530f7b98b982f24e572b4cafa80ced9
https://research.rug.nl/en/publications/dc6d5f33-f896-4101-898e-7cb729b030b5

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Influence of a subsequent meal on the oro-cecal transit time of a solid test meal

Autor: H Elzinga, RE Wachters-Hagedoorn, Roelf Vonk, Marion G. Priebe, J. Heimweg, K. Landman

Publikováno v: European Journal of Clinical Investigation, 36(2), 123-126. Wiley

Oro-cecal transit time (OCTT) is determined for clinical diagnostics of intestinal complaints and research purposes. Ingestion of a subsequent meal during the test period shortens the OCTT of a liquid test meal (glucose solution), as previously repor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dccc7986d775c4c1395abc39bb5754
https://pubmed.ncbi.nlm.nih.gov/16436094

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