The effects of IFN-gamma on CD40-mediated activation of B cells from X-linked immunodeficient or normal mice

Autor: C Johnson-Léger, J Hasbold, M Holman, G G Klaus

Publikováno v: The Journal of Immunology. 159:1150-1159

B cell activation induced by cross-linking of CD40 is enhanced by costimulation with certain T cell-derived cytokines (generally Th2 type), most notably IL-4. We show here that the induction of DNA synthesis in normal mouse B cells by anti-CD40 mAb i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70630f3c8488abfee20237fd6f45a5bf
https://doi.org/10.4049/jimmunol.159.3.1150

Transcriptional control (SY4-4)

Autor: Axel Kallies, Philip D. Hodgkin, C. E. Zorca, Wumesh Kc, David M. Tarlinton, J. Hasbold, H. Bandukwala, Jörn C. Albring, Christophe Benoist, Theresa L. Murphy, K. P. Koh, T. Ideker, Brian T. Edelson, Barbara U. Schraml, Kenneth M. Murphy, Richard A. Flavell, A. Xin, M. Feurer, Stephen L. Nutt, Lynn M. Corcoran, Ansuman T. Satpathy, Michelle M. Sandau, S. Carotta, W. Lee, C. G. Spilianakis, J. Dutkowski, J. C. Stroud, Diane Mathis, Y. Lin, C. Brenner, Ellen V. Rothenberg, Y. Chen, Erika Cretney, M. Kohyama-Ise, Y. Wu, M. S. Sundrud, Wataru Ise, Anjana Rao, Cornelis Murre, Lin Chen, C. Glass, Sankar Ghosh, Kai Hildner, Gabrielle T. Belz, Mona Mashayekhi, Li Wu

Publikováno v: International Immunology. 22:iv4-iv5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de8162281ee6cca62054a01e630638f3
https://doi.org/10.1093/intimm/dxq290

Flow cytometric cell division tracking using nuclei

Autor: J, Hasbold, P D, Hodgkin

Publikováno v: Cytometry. 40(3)

Labeling cells with 5-(and-6) carboxyfluorescein diacetate succinimidyl ester (CFSE) allows their subsequent division history to be determined by flow cytometry. Whether nuclei isolated from CFSE-labeled cells retain any or sufficient dye to reveal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b5a8bc577bcfa121afcadea342ac823
https://pubmed.ncbi.nlm.nih.gov/10878566

Integrating signals from IFN-gamma and IL-4 by B cells: positive and negative effects on CD40 ligand-induced proliferation, survival, and division-linked isotype switching to IgG1, IgE, and IgG2a

Autor: J, Hasbold, J S, Hong, M R, Kehry, P D, Hodgkin

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(8)

IL-4 and IFN-gamma each have potent effects on B cell responses as well as strong mutual antagonism. Here we have examined the quantitative effects of these cytokines on CD40 ligand-induced B cell proliferation, cell survival, and division-linked iso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::915457c11f5726cee3e93d4db4b1a017
https://pubmed.ncbi.nlm.nih.gov/10510353

Properties of mouse CD40: differential expression of CD40 epitopes on dendritic cells and epithelial cells

Autor: J. Hasbold, G. G. B. Klaus, Christine D. Dijkstra, Ed A. Döpp, C. Renardel De Lavalette, T. K. van den Berg

Publikováno v: Immunology, 88(2), 294-300. Wiley-Blackwell
Van Den Berg, T K, Hasbold, J, Renardel De Lavalette, C, Döpp, E A, Dijkstra, C D & Klaus, G G 1996, ' Properties of mouse CD40 : differential expression of CD40 epitopes on dendritic cells and epithelial cells ', Immunology, vol. 88, no. 2, pp. 294-300 .

In this study we describe the tissue distribution of mouse CD40 using two monoclonal antibodies (mAb) against different epitopes of the molecule. In lymphoid tissues CD40 was expressed by B lymphocytes. Most B cells in typical B-cell compartments wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305c1dae888fb47c7091ca3edb26df9a
https://research.vumc.nl/en/publications/d9f71a1a-a4cd-4450-9950-899575959a6f