Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes

Autor: Sanne G. S. Verberk, Hendrik J. P. van der Zande, Jeroen Baardman, Kyra E. de Goede, Karl J. Harber, Eelco D. Keuning, Joost M. Lambooij, Frank Otto, Anna Zawistowska-Deniziak, Helga E. de Vries, Menno P. J. de Winther, Bruno Guigas, Jan Van den Bossche

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Macrophages are highly plastic, key regulators of inflammation. Deregulation of macrophage activation can lead to excessive inflammation as seen in inflammatory disorders like atherosclerosis, obesity, multiple sclerosis and sepsis. Targeting intrace

Externí odkaz: https://doaj.org/article/eedffe2b80ad4e5590a19202f028c287

Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages

Autor: Karl J. Harber, Kyra E. de Goede, Sanne G. S. Verberk, Elisa Meinster, Helga E. de Vries, Michel van Weeghel, Menno P. J. de Winther, Jan Van den Bossche

Publikováno v: Metabolites, Vol 10, Iss 9, p 372 (2020)

Immunometabolism revealed the crucial role of cellular metabolism in controlling immune cell phenotype and functions. Macrophages, key immune cells that support progression of numerous inflammatory diseases, have been well described as undergoing vas

Externí odkaz: https://doaj.org/article/362e1315cbf4439eacd33d59b4a64102

Berberis hypoxantha C.Y. Wu ex S.Y. Bao (Berberidaceae), a new record for Vietnamese flora

Autor: T.T.T. Hoai, K.E. Hummer, J. Harber, N.Q. Vinh, N.D. Phuong, T.V. Tu

Publikováno v: Acta Horticulturae. :99-104

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e68c9ca47403e9181c185930ef7f615
https://doi.org/10.17660/actahortic.2021.1312.15

d-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation

Autor: Kyra E. de Goede, Karl J. Harber, Friederike S. Gorki, Sanne G.S. Verberk, Laszlo A. Groh, Eelco D. Keuning, Eduard A. Struys, Michel van Weeghel, Arvand Haschemi, Menno P.J. de Winther, Xanthe A.M.H. van Dierendonck, Jan Van den Bossche

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease, 1868
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1868(9):166427. Elsevier
de Goede, K E, Harber, K J, Gorki, F S, Verberk, S G S, Groh, L A, Keuning, E D, Struys, E A, van Weeghel, M, Haschemi, A, de Winther, M P J, van Dierendonck, X A M H & van den Bossche, J 2022, ' D-2-Hydroxyglutarate is an anti-inflammatory immunometabolite that accumulates in macrophages after TLR4 activation ', Biochimica et Biophysica Acta-Molecular Basis of Disease, vol. 1868, no. 9, 166427 . https://doi.org/10.1016/j.bbadis.2022.166427
Biochimica et biophysica acta. Molecular basis of disease, 1868, 9
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1868(9):166427. Elsevier

Contains fulltext : 251502.pdf (Publisher’s version ) (Open Access) Macrophages undergo extensive metabolic rewiring upon activation which assist the cell in roles beyond energy production and synthesis of anabolic building blocks. So-called immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c480bd1717fb6bb688024b463114cb
http://hdl.handle.net/2066/251502

An HLA-A*11:01-Binding Neoantigen from Mutated NPM1 as Target for TCR Gene Therapy in AML

Autor: Marieke Griffioen, Renate S. Hagedoorn, Peter A. van Veelen, Frederik Falkenburg, Annemiek M. Schouten, Kees L. M. C. Franken, Dennis F.G. Remst, Rogier M. Reijmers, Lisanne M. Roelofsen, Willy M. Honders, Hendrik Veelken, Michel G.D. Kester, Georgia Koutsoumpli, Jan W. Drijfhout, Tassilo L. A. Wachsmann, Mirjam H.M. Heemskerk, Arend Mulder, Karl J. Harber, Rob C. M. de Jong, Dyantha I. van der Lee

Publikováno v: Cancers; Volume 13; Issue 21; Pages: 5390
Cancers
Cancers, 13(21). MDPI
Cancers, Vol 13, Iss 5390, p 5390 (2021)

Simple Summary Acute myeloid leukemia (AML) is an aggressive hematological malignancy with poor prognosis. For AML relapses after chemotherapy, new and effective therapies are needed. In 30–35% of AMLs, a frameshift mutation in the nucleophosmin 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf645043026672d40ca9e97b4deb8364