Zobrazeno 1 - 10
of 48
pro vyhledávání: '"J. Hamblett"'
Autor:
Hailing Lu, Brian P O’Connor, Ryan A Heiser, Jason D Berndt, Michelle L Ulrich, Bryan M Grogan, Reice D James, Melissa Conerly, Astrid Clarke, Kevin J Hamblett
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/c709d4b04ff94a1e845877d6feb9447b
Autor:
William C. Fanslow, John S. Hill, Qing Chen, Steven L. Vonderfecht, Brian Twomey, Taruna Arora, David Meininger, Esther S. Trueblood, Ian N. Foltz, Hua Liu, Wesley S. Chang, Sophia Siu, Carl J. Kozlosky, Kevin J. Hamblett
Supplementary Figure S2. Cell Growth inhibition in A431 cells (wild-type EGFR overexpressing cells)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157c052f73fd90111b36159268b5cbaf
https://doi.org/10.1158/1535-7163.22502325
https://doi.org/10.1158/1535-7163.22502325
Autor:
William C. Fanslow, John S. Hill, Qing Chen, Steven L. Vonderfecht, Brian Twomey, Taruna Arora, David Meininger, Esther S. Trueblood, Ian N. Foltz, Hua Liu, Wesley S. Chang, Sophia Siu, Carl J. Kozlosky, Kevin J. Hamblett
Supplementary Figure Legends and Supplementary Table. Supplementary Table. EGFRvIII receptors/cell quantification of U251vIII and D317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03bcc3ebe52bd2ceb4e27bea2e01fbbc
https://doi.org/10.1158/1535-7163.22502331
https://doi.org/10.1158/1535-7163.22502331
Autor:
William C. Fanslow, Kim C. Quon, Matthew M. Bio, Margaret F. Weidner, Wesley S. Chang, Jason W. O'Neill, Christopher J. Borths, Dan A. Rock, Seamus P. Ragan, Sophia Siu, Robert R. Milburn, Sonal K. Patel, Brooke M. Rock, Mark E. Tometsko, Jesse L. Gurgel, Allison P. Jacob, Kevin J. Hamblett
Genes identified as critical for CD70 ADC function in Library 1 screen (S1); Genes identified as critical for CD70 ADC function in Library 2 screen (S2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afd7b980e59ed2ae74732dbadbd5224
https://doi.org/10.1158/0008-5472.22406852
https://doi.org/10.1158/0008-5472.22406852
Autor:
William C. Fanslow, Kim C. Quon, Matthew M. Bio, Margaret F. Weidner, Wesley S. Chang, Jason W. O'Neill, Christopher J. Borths, Dan A. Rock, Seamus P. Ragan, Sophia Siu, Robert R. Milburn, Sonal K. Patel, Brooke M. Rock, Mark E. Tometsko, Jesse L. Gurgel, Allison P. Jacob, Kevin J. Hamblett
Predicted topology for SLC46A3 (S1); Effect of siRNA on mRNA expression of SLC46A3 and CD70 in 786-0 cells (S2); Effect of siRNA on CD70 protein expression in 786-0 cells (S3); Anti-CD70 Ab-DSG-Maytansine and anti-CD70 Ab-Cys-Maytansine are potent ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eff3eb212c549f79dc7834903550168
https://doi.org/10.1158/0008-5472.22406858.v1
https://doi.org/10.1158/0008-5472.22406858.v1
Autor:
William C. Fanslow, Kim C. Quon, Matthew M. Bio, Margaret F. Weidner, Wesley S. Chang, Jason W. O'Neill, Christopher J. Borths, Dan A. Rock, Seamus P. Ragan, Sophia Siu, Robert R. Milburn, Sonal K. Patel, Brooke M. Rock, Mark E. Tometsko, Jesse L. Gurgel, Allison P. Jacob, Kevin J. Hamblett
Description of additional methods and procedures used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33716785c78c5ac8ae1ee739e76fa395
https://doi.org/10.1158/0008-5472.22406855.v1
https://doi.org/10.1158/0008-5472.22406855.v1
Publikováno v:
Cancer Research. 83:2633-2633
Zanidatamab zovodotin (ZW49) is an antibody drug conjugate (ADC) comprised of a bispecific anti-HER2 IgG1 antibody (ZW25, zanidatamab) conjugated to a microtubule inhibitor auristatin payload (ZD02044) via a protease cleavable linker. Clinical studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab51bc37180915858b581dcbcfdff31f
https://doi.org/10.1158/1538-7445.am2023-2633
https://doi.org/10.1158/1538-7445.am2023-2633
Autor:
Allison P. Jacob, Christopher J. Borths, Matthew M. Bio, Sophia Siu, Mark E. Tometsko, Kevin J. Hamblett, Jason W. O'Neill, Jesse L. Gurgel, Seamus Ragan, Margaret F. Weidner, William C. Fanslow, Brooke M. Rock, Wesley Chang, Kim Quon, Robert R. Milburn, Dan A. Rock, Sonal K. Patel
Publikováno v:
Cancer Research. 75:5329-5340
Antibody–drug conjugates (ADC) target cytotoxic drugs to antigen-positive cells for treating cancer. After internalization, ADCs with noncleavable linkers are catabolized to amino acid-linker-warheads within the lysosome, which then enter the cytop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c23aea6eea63c9112664b78d3d0eb62
https://doi.org/10.1158/0008-5472.can-15-1610
https://doi.org/10.1158/0008-5472.can-15-1610
Autor:
Steven Vonderfecht, Hua Liu, Brian Twomey, John S. Hill, Taruna Arora, William C. Fanslow, Kevin J. Hamblett, Ian Foltz, Sophia Siu, Esther S. Trueblood, Qing Chen, Carl J. Kozlosky, Wesley Chang, David Park Meininger
Publikováno v:
Molecular Cancer Therapeutics. 14:1614-1624
Epidermal growth factor receptor variant III (EGFRvIII) is a cancer-specific deletion mutant observed in approximately 25% to 50% of glioblastoma multiforme (GBM) patients. An antibody drug conjugate, AMG 595, composed of the maytansinoid DM1 attache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91834f94682f223cfe8edd2471c2a18
https://doi.org/10.1158/1535-7163.mct-14-1078
https://doi.org/10.1158/1535-7163.mct-14-1078
Autor:
Kevin J. Hamblett
Publikováno v:
Cancer Drug Discovery and Development ISBN: 9783319781532
Ado-trastuzumab emtansine, referred to as trastuzumab-MCC-DM1 or T-DM1, was the first antibody drug conjugate (ADC) approved for HER2 positive metastatic breast cancer. This chapter reviews the development of trastuzumab-MCC-DM1, summarizes novel ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e38078b0e424fc0c8bea415974ab851b
https://doi.org/10.1007/978-3-319-78154-9_7
https://doi.org/10.1007/978-3-319-78154-9_7