Zobrazeno 1 - 10
of 672
pro vyhledávání: '"J. Hallett"'
Autor:
Ria Thomas, Kyle J. Connolly, Oeystein R. Brekk, Anthony J. Hinrich, Michelle L. Hastings, Ole Isacson, Penelope J. Hallett
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Inflammatory processes and mechanisms are of central importance in neurodegenerative diseases. In the brain, α-synucleinopathies such as Parkinson’s disease (PD) and Lewy body dementia (LBD) show immune cytokine network activation and inc
Externí odkaz:
https://doaj.org/article/19fde4928a4f45e5b0fc284e1cba2d1f
Autor:
Hamidreza Siampour, Christopher O’Rourke, Alistair J. Brash, Maxim N. Makhonin, René Dost, Dominic J. Hallett, Edmund Clarke, Pallavi K. Patil, Maurice S. Skolnick, A. Mark Fox
Publikováno v:
npj Quantum Information, Vol 9, Iss 1, Pp 1-8 (2023)
Abstract Quantum states of light and matter can be manipulated on the nanoscale to provide a technological resource for aiding the implementation of scalable photonic quantum technologies. Experimental progress relies on the quality and efficiency of
Externí odkaz:
https://doaj.org/article/308780de77a943279cfec33178e7ffc1
Autor:
Garth J. Hallett
Humanity now stands at a crossroads between a world of unimaginable wonders and one of unprecedented terrors. The choices we make now will determine not only the shape of our future, but whether there will be, for us as a species, a future at all. Bu
Autor:
Kyle J. Connolly, Juliette Margaria, Erika Di Biase, Oliver Cooper, Penelope J. Hallett, Ole Isacson
Publikováno v:
Cells, Vol 12, Iss 21, p 2564 (2023)
Tightly regulated and highly adaptive lipid metabolic and transport pathways are critical to maintaining brain cellular lipid homeostasis and responding to lipid and inflammatory stress to preserve brain function and health. Deficits in the lipid han
Externí odkaz:
https://doaj.org/article/7a93c32a9bb34f7aab6684bf664fee10
Autor:
Martin A. Redhead, C. David Owen, Lennart Brewitz, Amelia H. Collette, Petra Lukacik, Claire Strain-Damerell, Sean W. Robinson, Patrick M. Collins, Philipp Schäfer, Mark Swindells, Chris J. Radoux, Iva Navratilova Hopkins, Daren Fearon, Alice Douangamath, Frank von Delft, Tika R. Malla, Laura Vangeel, Thomas Vercruysse, Jan Thibaut, Pieter Leyssen, Tu-Trinh Nguyen, Mitchell Hull, Anthony Tumber, David J. Hallett, Christopher J. Schofield, David I. Stuart, Andrew L. Hopkins, Martin A. Walsh
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Effective agents to treat coronavirus infection are urgently required, not only to treat COVID-19, but to prepare for future outbreaks. Repurposed anti-virals such as remdesivir and human anti-inflammatories such as barcitinib have received
Externí odkaz:
https://doaj.org/article/fb9698cf840e4e28863c13aafd4f244e
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-12 (2021)
Abstract Lysosomal dysfunction is a central pathway associated with Parkinson’s disease (PD) pathogenesis. Haploinsufficiency of the lysosomal hydrolase GBA (encoding glucocerebrosidase (GCase)) is one of the largest genetic risk factors for develo
Externí odkaz:
https://doaj.org/article/f1e4acd91f9f4b089c79f0c636b6d006
Autor:
Joanna A. Korecka, Ria Thomas, Anthony J. Hinrich, Alyssa M. Moskites, Zach K. Macbain, Penelope J. Hallett, Ole Isacson, Michelle L. Hastings
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 623-635 (2020)
Parkinson’s disease (PD) is a progressive neurological disorder estimated to affect 7–10 million people worldwide. There is no treatment available that cures or slows the progression of PD. Elevated leucine-rich repeat kinase 2 (LRRK2) activity h
Externí odkaz:
https://doaj.org/article/c35d1d9940544cb3b606f79c91e2929b
Autor:
Oeystein R. Brekk, Joanna A. Korecka, Cecile C. Crapart, Mylene Huebecker, Zachary K. MacBain, Sara Ann Rosenthal, Miguel Sena-Esteves, David A. Priestman, Frances M. Platt, Ole Isacson, Penelope J. Hallett
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of β-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2. There are shared features between SD and Parkinson’s disease (PD). α-synuclein (aSY
Externí odkaz:
https://doaj.org/article/a6679db376524eaf95dfb742563c7bce
Publikováno v:
Results in Chemistry, Vol 4, Iss , Pp 100307- (2022)
Three new EDTA-N, N’’ Bis(amides) ligands functionalized by luminophores (4-(aminomethyl)pyridine (L1) and 2-aminoanthraquinone (L2) and sulphonate (aminomethanesulfonic acid (L3)) on the amide side-arms (L1-L3) and their transition metal complex
Externí odkaz:
https://doaj.org/article/ec2c971569a9405e82e8b5cb92d7355f
Autor:
Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett, Frances M. Platt
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-21 (2019)
Abstract Background Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson’s disease (PD). Recently, more than fifty other lysosomal s
Externí odkaz:
https://doaj.org/article/8a3bdc7450e34016b365323d7a34ab17