Zobrazeno 1 - 10
of 204
pro vyhledávání: '"J. Hackel"'
Autor:
Joanan Lopez-Morales, Rosario Vanella, Elizabeth A. Appelt, Sarah Whillock, Alexandra M. Paulk, Eric V. Shusta, Benjamin J. Hackel, Chang C. Liu, Michael A. Nash
Publikováno v:
Small Science, Vol 3, Iss 12, Pp n/a-n/a (2023)
Yeast surface display (YSD) is a powerful tool in biotechnology that links genotype to phenotype. In this review, the latest advancements in protein engineering and high‐throughput screening based on YSD are covered. The focus is on innovative meth
Externí odkaz:
https://doaj.org/article/ddae0038718a4776a71f8c164540509e
Autor:
Dongwoo Hahn, Joseph D. Quick, Brian R. Thompson, Adelyn Crabtree, Benjamin J. Hackel, Frank S. Bates, Joseph M. Metzger
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Duchenne muscular dystrophy (DMD) is caused by the lack of dystrophin, a cytoskeletal protein essential for the preservation of the structural integrity of the muscle cell membrane. DMD patients develop severe skeletal muscle weakness, degen
Externí odkaz:
https://doaj.org/article/da57e682a1cf408ca948d597d44b4ef7
Autor:
Addeli Bez Batti Angulski, Houda Cohen, Mihee Kim, Dongwoo Hahn, Nicholas Van Zee, Timothy P. Lodge, Marc A. Hillmyer, Benjamin J. Hackel, Frank S. Bates, Joseph M. Metzger
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 162-176 (2023)
First-in-class membrane stabilizer Poloxamer 188 (P188) has been shown to confer membrane protection in an extensive range of clinical conditions; however, elements of the systemic distribution and localization of P188 at the organ, tissue, and muscl
Externí odkaz:
https://doaj.org/article/3a1e938556b44502a67ac72b87b2ecd7
Autor:
Nagamani Vunnam, MaryJane Been, Evan Huber, Carolyn Paulson, Sophia Szymonski, Benjamin J. Hackel, Jonathan N. Sachs
Publikováno v:
Molecular Pharmaceutics. 20:1884-1897
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22201fcd8169dec63c3b9197f795bdc2
https://doi.org/10.1021/acs.molpharmaceut.2c00385
https://doi.org/10.1021/acs.molpharmaceut.2c00385
Autor:
Christine Ambrose, Lihe Su, Lan Wu, Fay J Dufort, Thomas Sanford, Alyssa Birt, Benjamin J Hackel, Andreas Hombach, Hinrich Abken, Roy R Lobb, Paul D Rennert
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0247701 (2021)
Successful CAR T cell therapy for the treatment of solid tumors requires exemplary CAR T cell expansion, persistence and fitness, and the ability to target tumor antigens safely. Here we address this constellation of critical attributes for successfu
Externí odkaz:
https://doaj.org/article/79b29881299c40a5997a27b51c18789e
Autor:
Daniel T. Tresnak, Benjamin J. Hackel
Publikováno v:
ACS Synthetic Biology. 12:249-264
Antibiotic-resistant infectious disease is a critical challenge to human health. Antimicrobial proteins offer a compelling solution if engineered for potency, selectivity, and physiological stability. Lysins, which lyse cells via degradation of cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d392ef97cec1912809b9ab4ab3ecc9
https://doi.org/10.1021/acssynbio.2c00509
https://doi.org/10.1021/acssynbio.2c00509
Autor:
Manjie Huang, Marina Rueda-Garcia, Abbigael Harthorn, Benjamin J. Hackel, James A. Van Deventer
Protein-small molecule hybrids are structures that have the potential to combine the inhibitory properties of small molecules and the specificities of binding proteins. However, achieving such synergies is a substantial engineering challenge, with fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5151a5a6981311d363cb4ff80d82f618
https://doi.org/10.1101/2023.05.12.540568
https://doi.org/10.1101/2023.05.12.540568
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Poly(ethylene oxide) (PEO) and poloxamers, a class of poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers, have many personal and medical care applications, including the stabilization of stressed cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52e098c8129d1fbdbacf4a70d7fa4ada
https://doi.org/10.1073/pnas.2219885120
https://doi.org/10.1073/pnas.2219885120
Autor:
Joseph F. Hassler, Nicholas J. Van Zee, Adelyn A. Crabtree, Frank S. Bates, Benjamin J. Hackel, Timothy P. Lodge
Publikováno v:
ACS Macro Lett
Bottlebrush polymers are characterized by an expansive parameter space, including graft length and spacing along the backbone, and these features impact various structural and physical properties such as molecular diffusion and bulk viscosity. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518cdb9eec50c6cc8bdced6bafbd39b0
https://pubmed.ncbi.nlm.nih.gov/35575325
https://pubmed.ncbi.nlm.nih.gov/35575325
All supplemental figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fdbafde967165affc1283240531a7d
https://doi.org/10.1158/1535-7163.22504326.v1
https://doi.org/10.1158/1535-7163.22504326.v1