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The role of anterior segmental osteotomies in orthognathic surgery for protrusive faces in a Southeast Asian population: 10-year retrospective data of 51 patients treated in a single centre

Autor: C W, Yong, T J H, Sng, B, Quah, C K J, Lee, A A T, Lim, R C W, Wong

Publikováno v: International Journal of Oral and Maxillofacial Surgery. 52:468-475

Bimaxillary protrusion is a dentofacial deformity common in the East Asian population. It is often difficult to decide between orthodontic and surgical retraction to treat patients with bimaxillary protrusion, especially if surgery to correct skeleta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e448bce7ede90d70b21cb08b6b537b18
https://doi.org/10.1016/j.ijom.2022.08.013

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Beyond diabetes mellitus: role of metformin in non-muscle-invasive bladder cancer

Autor: Edmund Chiong, Ziting Wang, Wilson Ying Fa Ong, Shen Tong, J. H. Sng, Raman Mani Lata, Esuvaranathan Kesavan, Ratha Mahendran

Publikováno v: Singapore Med J

INTRODUCTION Usage of metformin is associated with improved survival in lung, breast and prostate cancer, and metformin has been shown to inhibit cancer cell growth and proliferation in in vitro studies. Given the lack of clinical data on metformin u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fed2687ff4be76215e15c9a989ed8f
https://europepmc.org/articles/PMC9251265/

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Akademický článek

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Comprehensive spectrum ofBRCA1andBRCA2deleterious mutations in breast cancer in Asian countries

Autor: Sung Won Kim, Eunyoung Kang, Ava Kwong, Tsun Leung Chan, Ann S.G. Lee, Vivian Y. Shin, Edmond S. K. Ma, Jeffrey N. Weitzel, Seigo Nakamura, Allison W. Kurian, Man Ting Siu, John C.W. Ho, J. H. Sng, Ophira Ginsburg, Fian B.F. Law, Soo Hwang Teo, James M. Ford, Steven A. Narod

Publikováno v: Journal of Medical Genetics. 53:15-23

Approximately 5%–10% of breast cancers are due to genetic predisposition caused by germline mutations; the most commonly tested genes are BRCA1 and BRCA2 mutations. Some mutations are unique to one family and others are recurrent; the spectrum of B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856c47bb4d21e0194005a5eb31fd95e8
https://doi.org/10.1136/jmedgenet-2015-103132

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Are Medullary Breast Cancers an Indication for BRCA1 Mutation Screening? A Mutation Analysis of 42 Cases of Medullary Breast Cancer

Autor: H.E. Denley, N.A. Scott, P T C Iau, Ian O. Ellis, P Wenzyck, Azhar Ali, J. H. Sng, Sarah E Pinder, R D Macmillan, G. Cross, M. Marafie, Roger W. Blamey

Publikováno v: Breast Cancer Research and Treatment. 85:81-88

Recommended guidelines have limited breast cancer gene ( BRCA1 ) mutation testing to individuals with a personal or family history of early onset breast and/or ovarian cancer, and those with multiple affected close relatives. Such large breast cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9562b1b97e10694dfc2598b2566c3bb0
https://doi.org/10.1023/b:brea.0000021049.61839.e5

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The prevalence of BRCA1 mutations in Chinese patients with early onset breast cancer and affected relatives

Autor: S. Van Der Pool, W. Tan, Jenny C. Chang, J. H. Sng, M. Lehnert, Nazneen Rahman, Su Bin Lim, J. Wong, F. Feroze

Publikováno v: British Journal of Cancer

The purpose of this study was to determine the prevalence of BRCA1 mutations in Chinese breast cancer patients in Singapore. BRCA1 analysis was conducted in consecutive patients with breast cancer before the age of 40 years (76 women), or whose relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697c66054c9dcc94b6b92ff92075d3e7
https://doi.org/10.1054/bjoc.1999.0960

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