Výsledky vyhledávání - "J. H. Nilson"

Expression of the genes encoding bovine LH in a line of Chinese hamster ovary cells

Autor: J. H. Nilson, D. M. Kaetzel

Publikováno v: Bioscientifica Proceedings.

Synthesis of biologically active LH is complex, due in part to its heterodimeric subunit structure and to the numerous post-translation modifications of each subunit. Through the use of mammalian expression vectors we have been able to introduce the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13766a460d93eef56d92fb8af3e82f9d
https://doi.org/10.1530/biosciprocs.9.017

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Chronic hypersecretion of luteinizing hormone in transgenic mice disrupts both ovarian and pituitary function, with some effects modified by the genetic background

Autor: J H, Nilson, R A, Abbud, R A, Keri, C C, Quirk

Publikováno v: Recent progress in hormone research. 55

When the pituitary or hypothalamus becomes resistant to steroid negative feedback, a vicious cycle ensues, resulting in chronic hypersecretion of luteinizing hormone (LH) from the pituitary and steroids from the ovaries. In women, LH hypersecretion i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81fd62ab5bf503e4337f041fb99b7951
https://pubmed.ncbi.nlm.nih.gov/11036934

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Transgenic mice with chronically elevated luteinizing hormone are infertile due to anovulation, defects in uterine receptivity, and midgestation pregnancy failure

Autor: R J, Mann, R A, Keri, J H, Nilson

Publikováno v: Endocrinology. 140(6)

Elevated levels of LH have been associated with infertility and miscarriage in women. Previously, we have reported generating a transgenic mouse model that hypersecretes LH. Female transgenics exhibit extensive pathology including enlarged, cystic, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b528c112d8fb4262f6ab1c6a3de8051c
https://pubmed.ncbi.nlm.nih.gov/10342846

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Characterization of the equine glycoprotein hormone alpha-subunit gene reveals divergence in the mechanism of pituitary and placental expression

Autor: T A, Farmerie, R A, Abbud, P R, Budworth, C M, Clay, R A, Keri, K J, McDowell, M W, Wolfe, J H, Nilson

Publikováno v: Biology of reproduction. 57(5)

The equine glycoprotein hormone alpha-subunit gene is expressed in both pituitary and placenta, unlike that of all other nonprimate mammals studied, in which expression is limited to pituitary. Previous studies of the 5'-flanking region of the equine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d925e22e00d688a83f5342234745504
https://pubmed.ncbi.nlm.nih.gov/9369177

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Chronically elevated luteinizing hormone depletes primordial follicles in the mouse ovary

Autor: J A, Flaws, R, Abbud, R J, Mann, J H, Nilson, A N, Hirshfield

Publikováno v: Biology of reproduction. 57(5)

A few years before reproductive senescence, primordial follicles are depleted from the ovary at a dramatically accelerated rate. It has been proposed that this depletion is due to transient increases in gonadotropin levels. To test this hypothesis, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::801233b847515aa2c08aa38c0c8e5fbd
https://pubmed.ncbi.nlm.nih.gov/9369192

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Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology

Autor: K A, Risma, A N, Hirshfield, J H, Nilson

Publikováno v: Endocrinology. 138(8)

In women, chronically elevated androgens have been associated with polycystic ovarian syndrome and infertility. Recently, we described transgenic mice with elevated serum LH secondary to targeted expression of a transgene encoding a chimeric LH beta-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df2043177e001060027fe642efd98e62
https://pubmed.ncbi.nlm.nih.gov/9231809

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Functional analysis of the placenta-specific enhancer of the human glycoprotein hormone alpha subunit gene. Emergence of a new element

Autor: R H, Pittman, C M, Clay, T A, Farmerie, J H, Nilson

Publikováno v: The Journal of biological chemistry. 269(30)

Placental expression of the alpha subunit gene of the human glycoprotein hormones requires a multicomponent enhancer composed of tandem cAMP-response elements and an adjacent upstream regulatory element. Based on recent studies indicating that the up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::12b2f815fe76908d4d044f6facbfb2fe
https://pubmed.ncbi.nlm.nih.gov/8034701

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Expression of the beta subunit of chorionic gonadotropin in transgenic mice

Autor: B L, Strauss, R, Pittman, M R, Pixley, J H, Nilson, I, Boime

Publikováno v: The Journal of biological chemistry. 269(7)

Transcriptional activation of the chorionic gonadotropin (CG) genes is linked to trophoblast differentiation. In a multistep process, cytotrophoblasts expressing only the alpha subunit differentiate into intermediates that coexpress the CG beta subun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e76c88dd0a9ff46c702e410fefedc8b
https://pubmed.ncbi.nlm.nih.gov/7508931

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