Výsledky vyhledávání - "J. H. M. Prehn"

Clinical Oncogenomics and Personalized Medicine in Colorectal Cancer for the Surgeon: What We Need to Know and What the Future Holds

Autor: I. S. Reynolds, E. O’Connell, D. A. McNamara, J. H. M. Prehn, S. J. Furney, J. P. Burke

Publikováno v: SN Comprehensive Clinical Medicine. 4

Abstract Changes in the normal nucleotide sequence of the human genome plays an integral part in the development and progression of all cancers. It is now recognized that certain genomic alterations can be used to determine prognosis and potential re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a169a058011b62dfc589b8134710bb06
https://doi.org/10.1007/s42399-022-01144-x

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Mucinous and non-mucinous colorectal cancers show differential expression of chemotherapy metabolism and resistance genes

Autor: E, O'Connell, I S, Reynolds, M, Salvucci, D A, McNamara, J P, Burke, J H M, Prehn

Publikováno v: The pharmacogenomics journal. 21(4)

Previous research has identified differences in mutation frequency in genes implicated in chemotherapy resistance between mucinous and non-mucinous colorectal cancers (CRC). We hypothesized that outcomes in mucinous and non-mucinous CRC may be influe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ced874cb83173dddcc07d6d1a005a7b
https://pubmed.ncbi.nlm.nih.gov/33731881

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Effect of the N-methyl-D-aspartate NR2B subunit antagonist ifenprodil on precursor cell proliferation in the hippocampus

Autor: E C, Bunk, H-G, König, J H M, Prehn, B P, Kirby

Publikováno v: Journal of neuroscience research. 92(6)

The N-methyl-D-aspartate (NMDA) receptor, one of the ionotropic glutamate receptor, plays important physiological and pathological roles in learning and memory, neuronal development, acute and chronic neurological diseases, and neurogenesis. This wor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca2af64b6f97ac73ea3384d6394e317d
https://pubmed.ncbi.nlm.nih.gov/24464409

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Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer

Autor: B, Weyhenmeyer, A C, Murphy, J H M, Prehn, B M, Murphy

Publikováno v: Experimental oncology. 34(3)

Most cells express a variety of both anti-apoptotic and pro-apoptotic Bcl-2 proteins and the interaction within this family dictates whether a cell survives or dies. The dysregulation of the anti-anti-apoptotic Bcl-2 family members is one of the defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::384fb935b2819412944b1b3f0fdce77d
https://pubmed.ncbi.nlm.nih.gov/23070004

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The Self-Destruction of Neurons Physiological and Pathophysiological Decisions for the Functional Integrity

Autor: J. H. M. Prehn, D. Kögel

Publikováno v: Brain Damage and Repair ISBN: 9789048165384

A major challenge in current neuroscience research is to understand the molecular mechanisms leading to neuronal apoptosis in neurodegenerative diseases and after acute brain insults. Neuronal apoptosis which has a crucial function for elimination of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44f6d39fa9f031626ce7d92c8d14266d
https://doi.org/10.1007/1-4020-2541-6_6

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TARGETING THE 19S PROTEASOMAL SUBUNIT, RPT4, IN COLON CANCER CELLS INDUCES CELL DEATH AND REDUCES CELLULAR PROLIFERATION IN VITRO AND IN VIVO

Autor: K Boland, N McCawley, D Ryan, S Hector, E Kay, D McNamara, F Murray, C G Concannon, J H M Prehn

Publikováno v: Gut. 62:A3.1-A3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16372e613cf914aeea86deed471d5ac2
https://doi.org/10.1136/gutjnl-2013-305143.6

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