Zobrazeno 1 - 10 of 12 pro vyhledávání: '"J. H. Krushinski"'
1
N-Methyl-5-tert-butyltryptamine: A Novel, Highly Potent 5-HT1D Receptor Agonist
Autor: Clint Duane Walker, James E. Audia, John Mehnert Schaus, Nika Adham, John M. Zgombick, J. H. Krushinski, Daniel Timothy Kohlman, Sidney Xi Liang, Yao-Chang Xu
Publikováno v: Journal of Medicinal Chemistry. 42:526-531
It has been observed that reported 5-HT1D receptor agonists have at least one heteroatom (N, O, or S) on the 5-substituent of the indole. This has led to the hypothesis that a 5-substituent capable of participating in hydrogen bonding is critical for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadef5240ece5af98289e5bf05a1c99b
https://doi.org/10.1021/jm9805945
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3
ChemInform Abstract: N-Methyl-5-tert-butyltryptamine: A Novel, Highly Potent 5-HT1D Receptor Agonist
Autor: Sidney Xi Liang, Yao-Chang Xu, Daniel Timothy Kohlman, John M. Zgombick, Nika Adham, J. H. Krushinski, Clint Duane Walker, John Mehnert Schaus, James E. Audia
Publikováno v: ChemInform. 30
It has been observed that reported 5-HT1D receptor agonists have at least one heteroatom (N, O, or S) on the 5-substituent of the indole. This has led to the hypothesis that a 5-substituent capable of participating in hydrogen bonding is critical for
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b9f5494fe5fc797343d44e04c4245fb
https://doi.org/10.1002/chin.199923140
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4
Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake
Autor: Dennis Charles Thompson, Frank P. Bymaster, Louise Wallace, E. E. Beedle, David W. Robertson, Peter Thaddeus Gallagher, Stephen N. Mitchell, J. H. Krushinski, David T. Wong, Jeremy Findlay
Publikováno v: Bioorganicmedicinal chemistry letters. 13(24)
A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9047f6380da276771c6308edbf0c6b14
https://pubmed.ncbi.nlm.nih.gov/14643350
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7
Structure-activity relationships of (arylalkyl)imidazole anticonvulsants: comparison of the (fluorenylalkyl)imidazoles with nafimidone and denzimol
Autor: J. H. Krushinski, R. C. Rathbun, David T. Wong, J D Leander, David W. Robertson, E. E. Beedle
Publikováno v: Journal of Medicinal Chemistry. 29:1577-1586
A recently discovered and structurally distinct class of antiepileptic drugs is the (arylalkyl)imidazoles. Two independently discovered representatives of this class, denzimol (alpha-[4-(2-phenylethyl)phenyl]-1H-imidazole-1-ethanol) and nafimidone (2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9048811e0de9fb9e0a93e5ca63b2f7
https://doi.org/10.1021/jm00159a004
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8
Structure-activity relationships of arylimidazopyridine cardiotonics: discovery and inotropic activity of 2-[2-methoxy-4-(methylsulfinyl)phenyl]-1H-imidazo[4,5-c]pyridine
Autor: David W. Robertson, H. Wilson, E. E. Beedle, Hayes Js, G. D. Pollock, J. H. Krushinski, V. L. Wyss
Publikováno v: Journal of medicinal chemistry. 28(6)
Recently several noncatecholamine, nonglycoside cardiotonic drugs have been discovered that possess both inotropic and vasodilator activities in experimental animals and man. Prototypical compounds include amrinone, sulmazole, and fenoximone. We inve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e72a9c27246f6af9d5c4728528decb
https://pubmed.ncbi.nlm.nih.gov/4009593
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9
ChemInform Abstract: Dihydropyridazinone Cardiotonics: Synthesis and Inotropic Activity of 5′-(1,4,5,6-Tetrahydro-6-oxo-3-pyridazinyl)spiro(cycloalkane-1,3′-(3H)indol)-2′(1′H)-ones
Autor: H. Wilson, J. H. Krushinski, R. F. Kauffman, Hayes Js, David W. Robertson, G. D. Pollock
Publikováno v: ChemInform. 18
In the 1,3-dihydro-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-2H-indol-2-one series of cardiotonics, we found that a spirocycloalkyl ring may be annealed to the 3-position of the indolone moiety while retaining inotropic activity. An inverse relation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7915ec4adc743df747e5920cdb19445
https://doi.org/10.1002/chin.198747189
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10
Molecular structure of the dihydropyridazinone cardiotonic 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-pyridazinyl)- 2H-indol-2-one, a potent inhibitor of cyclic AMP phosphodiesterase
Autor: D W, Robertson, N D, Jones, J H, Krushinski, G D, Pollock, J K, Swartzendruber, J S, Hayes
Publikováno v: Journal of medicinal chemistry. 30(4)
The cardiotonic 1,3-dihydro-3,3-dimethyl-5-(1,4,5,6-tetrahydro-6-oxo-3- pyridazinyl)-2H-indol-2-one (1, LY195115) is a potent, competitive inhibitor (Ki = 80 nM) of sarcoplasmic reticulum derived phosphodiesterase (SR-PDE). Moreover, the compound is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::41aba998655466291afe2aabc8acab3b
https://pubmed.ncbi.nlm.nih.gov/3031290
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