Zobrazeno 1 - 10
of 175
pro vyhledávání: '"J. H. Krushinski"'
Autor:
Clint Duane Walker, James E. Audia, John Mehnert Schaus, Nika Adham, John M. Zgombick, J. H. Krushinski, Daniel Timothy Kohlman, Sidney Xi Liang, Yao-Chang Xu
Publikováno v:
Journal of Medicinal Chemistry. 42:526-531
It has been observed that reported 5-HT1D receptor agonists have at least one heteroatom (N, O, or S) on the 5-substituent of the indole. This has led to the hypothesis that a 5-substituent capable of participating in hydrogen bonding is critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadef5240ece5af98289e5bf05a1c99b
https://doi.org/10.1021/jm9805945
https://doi.org/10.1021/jm9805945
Autor:
Bruce D. Gitter, Steven S. Y. Cho, Diane C. Waters, Donald R. Gehlert, Thomas Alan Crowell, Brian Stephen Muehl, Penny G. Threlkeld, Kirk W. Johnson, J. H. Krushinski, Karen Lynn Lobb, Robert F. Bruns, Philip Arthur Hipskind, Domenico Regoli, Lee A. Phebus, Nixon James Arthur, Smriti Iyengar, J. Jeffry Howbert, Dominic L. Li, Foreman Mark Mortensen, Norman R. Mason, Rosa Maria A. Simmons
Publikováno v:
ChemInform. 27
Early structure−activity studies on racemic tryptophan ester and amide NK-1 antagonists 5−7 led to the discovery that the potency of the series could be markedly increased by moving the carbonyl function in these molecules to an off-chain positio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d4b6978086b543b61febe41890ebd9
https://doi.org/10.1002/chin.199621130
https://doi.org/10.1002/chin.199621130
ChemInform Abstract: N-Methyl-5-tert-butyltryptamine: A Novel, Highly Potent 5-HT1D Receptor Agonist
Autor:
Sidney Xi Liang, Yao-Chang Xu, Daniel Timothy Kohlman, John M. Zgombick, Nika Adham, J. H. Krushinski, Clint Duane Walker, John Mehnert Schaus, James E. Audia
Publikováno v:
ChemInform. 30
It has been observed that reported 5-HT1D receptor agonists have at least one heteroatom (N, O, or S) on the 5-substituent of the indole. This has led to the hypothesis that a 5-substituent capable of participating in hydrogen bonding is critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b9f5494fe5fc797343d44e04c4245fb
https://doi.org/10.1002/chin.199923140
https://doi.org/10.1002/chin.199923140
Autor:
Dennis Charles Thompson, Frank P. Bymaster, Louise Wallace, E. E. Beedle, David W. Robertson, Peter Thaddeus Gallagher, Stephen N. Mitchell, J. H. Krushinski, David T. Wong, Jeremy Findlay
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(24)
A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9047f6380da276771c6308edbf0c6b14
https://pubmed.ncbi.nlm.nih.gov/14643350
https://pubmed.ncbi.nlm.nih.gov/14643350
Autor:
Steven S. Y. Cho, Penny G. Threlkeld, Nixon James Arthur, Robert F. Bruns, Lee A. Phebus, Thomas Alan Crowell, Karen Lynn Lobb, Kirk W. Johnson, Donald R. Gehlert, Diane C. Waters, Bruce D. Gitter, Brian Stephen Muehl, J. H. Krushinski, Norman R. Mason, Rosa Maria A. Simmons, Domenico Regoli, J. Jeffry Howbert, Dominic L. Li, Foreman Mark Mortensen, Smriti Iyengar, Philip Arthur Hipskind
Publikováno v:
Journal of medicinal chemistry. 39(3)
Early structure-activity studies on racemic tryptophan ester and amide NK-1 antagonists 5-7 led to the discovery that the potency of the series could be markedly increased by moving the carbonyl function in these molecules to an off-chain position as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e905dd4cdd9b11a6c3ff4b2cc709422
https://pubmed.ncbi.nlm.nih.gov/8576917
https://pubmed.ncbi.nlm.nih.gov/8576917
Publikováno v:
Clinical Neuropharmacology. 15:439B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8f47dd45ca36ca526d6be2764599731
https://doi.org/10.1097/00002826-199202001-00853
https://doi.org/10.1097/00002826-199202001-00853
Autor:
Lin, Daniel1 (AUTHOR), Coe, Matthew1 (AUTHOR), Krishnamurti, Vinayak1 (AUTHOR), Ispizua‐Rodriguez, Xanath1 (AUTHOR), Surya Prakash, G. K.1 (AUTHOR) gprakash@usc.edu
Publikováno v:
Chemical Record. Sep2023, Vol. 23 Issue 9, p1-35. 35p.
Autor:
J. H. Krushinski, R. C. Rathbun, David T. Wong, J D Leander, David W. Robertson, E. E. Beedle
Publikováno v:
Journal of Medicinal Chemistry. 29:1577-1586
A recently discovered and structurally distinct class of antiepileptic drugs is the (arylalkyl)imidazoles. Two independently discovered representatives of this class, denzimol (alpha-[4-(2-phenylethyl)phenyl]-1H-imidazole-1-ethanol) and nafimidone (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9048811e0de9fb9e0a93e5ca63b2f7
https://doi.org/10.1021/jm00159a004
https://doi.org/10.1021/jm00159a004
Autor:
Ramkumar, Nagarajan1 (AUTHOR), Sperga, Arturs1 (AUTHOR), Belyakov, Sergey1 (AUTHOR), Mishnev, Anatoly1 (AUTHOR), Zacs, Dzintars2 (AUTHOR), Veliks, Janis1 (AUTHOR) janis.veliks@osi.lv
Publikováno v:
Advanced Synthesis & Catalysis. 5/12/2023, Vol. 365 Issue 9, p1405-1412. 8p.
Autor:
Bertoli, Giulia1 (AUTHOR), Martínez, Ángel Manu1 (AUTHOR), Goebel, Jonas F.1 (AUTHOR), Belmonte, Debora1 (AUTHOR), Sivendran, Nardana1 (AUTHOR), Gooßen, Lukas J.1 (AUTHOR) lukas.goossen@ruhr-uni-bochum.de
Publikováno v:
Angewandte Chemie. 1/26/2023, Vol. 135 Issue 5, p1-6. 6p.