Výsledky vyhledávání - "J. H. Hutchinson"

Pharmacodynamics, Pharmacokinetics, and Safety of AM211: A Novel and Potent Antagonist of the Prostaglandin D2Receptor Type 2

Autor: B. Stearns, C. D. King, I. DeArmond, J. Brittain, Y. P. Truong, J. H. Hutchinson, Jilly F. Evans, J. P. Hartung, K. Holme, G. Bain

Publikováno v: The Journal of Clinical Pharmacology. 52:1482-1493

The prostaglandin D(2) receptor type 2 (DP2) and its ligand, PGD(2), have been implicated in the development of asthma and other inflammatory diseases. The authors evaluated the pharmacodynamics, pharmacokinetics and safety of [2'-(3-benzyl-1-ethyl-u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77137b64d44a34fa67ac7732dd6189f3
https://doi.org/10.1177/0091270011421912

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Disposition of a novel and potent αvβ3antagonist in animals, and extrapolation to man

Autor: T, Prueksaritanont, C, Fernandez-Metzler, Y, Meng, A, Barrish, W, Halczenko, S B, Rodan, J H, Hutchinson, M E, Duggan, J H, Lin

Publikováno v: Xenobiotica. 34:103-115

1. The disposition of 3-[2-oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthyridin-2-yl) propyl]-imidazolidin-1-yl]-3(S)-(6-methoxy-pyridin-3-yl)propionic acid (compound A), a potent and selective alpha(v)beta(3) antagonist, was characterized in several anima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c104e46c2b568b34b30e9bc2fcfaa5a
https://doi.org/10.1080/713767592

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A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model

Autor: JS Swaney, TJ Seiders, CS Baccei, P Fagan, Jillian F. Evans, A M Santini, PC Prodanovich, TA Parr, J. H. Hutchinson, LD Correa, DS Lorrain, RA Bundey, Petpiboon Prasit, C Chapman, KJ Stebbins

The aim of this study was to assess the potential of an antagonist selective for the lysophosphatidic acid receptor, LPA(1), in treating lung fibrosis We evaluated the in vitro and in vivo pharmacological properties of the high affinity, selective, o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb659d2677e2bbd216e7d64f6d7bacc
https://europepmc.org/articles/PMC2936842/

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Pharmacodynamics and pharmacokinetics of AM103, a novel inhibitor of 5-lipoxygenase-activating protein (FLAP)

Autor: G. Bain, M Moran, P Schuilenga-Hut, P Prasit, K Schaab, J M Arruda, S van de Wetering de Rooij, D Shapiro, A F Roffel, G L Milne, DS Lorrain, A M Santini, C. D. King, Jilly F. Evans, Y Li, J. H. Hutchinson, M Rewolinski

Publikováno v: Clinical pharmacology and therapeutics. 87(4)

The 5-lipoxygenase-activating protein (FLAP) gene and an increase in leukotriene (LT) production are linked to the risk of asthma, myocardial infarction, and stroke. We evaluated the pharmacodynamics, pharmacokinetics, and tolerability of 3-[3-tert-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576d63e0fb1685091a3a2d6934c6640f
https://pubmed.ncbi.nlm.nih.gov/20182424

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In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a prodrug candidate

Autor: T, Prueksaritanont, L M, Gorham, M J, Breslin, J H, Hutchinson, G D, Hartman, K P, Vyas, T A, Baillie

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 25(8)

The present study demonstrates the utility of an in vitro-in vivo correlative approach in the selection of an optimum prodrug candidate of L-767,679 (N-([7-(piperazin-1-yl)-3,4-dihydro-1(1H)-isoquinolinone-2-yl]acetyl)-3(S)-(ethynyl)-beta-alanine), a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f498549b2c4a50b0c5276eef59ac263d
https://pubmed.ncbi.nlm.nih.gov/9280406

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SomeN-substituted 2-amino- and 2-methylquinoline-3,4-dicarboximides

Autor: J. H. Hutchinson, E. Campaigne

Publikováno v: Journal of Heterocyclic Chemistry. 7:655-659

The reaction of sodium 2-amino-3-cyanoquinoline-4-carboxylate and 2-methyl-3-cyanoquino-line-4-carboxylic acid in polyphosphoric acid led to 2-amino- and 2-methylquinoline-3,4-dicar-boximide, respectively. Both of these compounds undergo imide N-alky

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50a36f453c4e70a0850175795d87d2d1
https://doi.org/10.1002/jhet.5570070329

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