Zobrazeno 1 - 10
of 15
pro vyhledávání: '"J. H. G. M. Van Beek"'
Autor:
C. J. A. Van Echteld, M. G. J. Nederhoff, I. Mottet, M. H. J. Eijgelshoven, J. H. G. M. Van Beek, Nico Westerhof
Publikováno v:
Circulation Research. 75:751-759
To investigate the dynamic control of cardiac ATP synthesis, we simultaneously determined the time course of mitochondrial oxygen consumption with the time course of changes in high-energy phosphates following steps in cardiac energy demand. Isolated
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 265:H2081-H2085
We investigated whether a glycolytic burst contributes to the initial adaptation of ATP synthesis to increased cardiac metabolic demand. Six isolated rabbit hearts were perfused with glucose-containing Tyrode solution at 28 degrees C. In venous and a
Publikováno v:
Magnetic Resonance in Medicine. 29:559-562
In this study we show the possibility of continuous oxygen tension measurement inside an NMR magnet without disturbance of simultaneous NMR data acquisition. Our modified Clark-type oxygen electrode has a fast response (2 s) and can be inserted deep
Publikováno v:
The Journal of Physiology. 447:17-31
1. In this study we determined the temperature dependence of the mean response time of cardiac mitochondrial oxygen consumption following steps in metabolic demand. Metabolic demand was altered by stepwise changes in heart rate or in left ventricular
Publikováno v:
Annals of the New York Academy of Sciences. 591:392-401
The distribution of myocardial blood flows was found by Yipintsoi et al1 to be surprisingly broad, broader than could be expected from variation in the microsphere technique itself in their studies of anesthetized dog hearts. This was observed by oth
Autor:
O, Kongas, J H G M, van Beek
Publikováno v:
Molecular biology reports. 29(1-2)
The regulation of mitochondrial respiration in the intact heart may differ from that of isolated mitochondria if intracellular diffusion is restricted. Here we consider which factors may hinder diffusion in vivo and, based on computational analysis,
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 259:H1606-H1608
In isolated hearts perfused with salt solutions, albumin is often added in low concentrations for preservation of endothelial function. Albumin in low concentrations is also sometimes used as an intravascular indicator in such preparations. We perfus
Autor:
J. H. G. M. Van Beek, T. Teerlink, J. Bussemaker, M. Hennekes, Lambertus G. Thijs, Nico Westerhof, A.B.J. Groeneveld
Publikováno v:
Journal of molecular and cellular cardiology. 26(8)
To study whether heterogeneous myocardial blood flow relates to the local oxidative capacity of cardiac muscle, local blood flow at resting cardiac workloads and the activity of the mitochondrial enzyme succinate dehydrogenase (SDH) were determined i
Publikováno v:
The American journal of physiology. 265(6 Pt 2)
The purpose of the present study was to determine whether the mean response time of cardiac mitochondrial oxygen consumption after a step in metabolic demand is constant in heart muscle, as has already been found for skeletal muscle. The mean respons
Autor:
Nico Westerhof, J. H. G. M. Van Beek
Publikováno v:
The American journal of physiology. 260(2 Pt 2)
We investigated the time course of cardiac mitochondrial O2 consumption following steps in heart rate in 16 isolated rabbit hearts perfused with Tyrode solution. The time course was characterized by the mean response time, i.e., the first statistical