Zobrazeno 1 - 10 of 13 pro vyhledávání: '"J. H. Fentem"'
1
Progress Toward the Validation of Alternative Tests
Autor: M, Balls, J H, Fentem
Publikováno v: Alternatives to laboratory animals : ATLA. 25(1)
ECVAM's role in the practical validation of replacement alternative methods for use in regulatory testing is reviewed, including an outline of the criteria which have been used in determining ECVAM's priorities. Some of the difficulties which have ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa6fd76b442045955f6f892ec46981b5
https://pubmed.ncbi.nlm.nih.gov/26554348
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3
An evaluation of the proposed OECD testing strategy for skin corrosion
Autor: A P, Worth, J H, Fentem, M, Balls, P A, Botham, R D, Curren, L K, Earl, D J, Esdaile
Publikováno v: Alternatives to laboratory animals : ATLA. 26(5)
The use of testing strategies which incorporate a range of alternative methods and which use animals only as a last resort is widely considered to provide a reliable way of predicting chemical toxicity while minimising animal testing. The widespread
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::89c13fef7363f2453b3c2de6db167ae2
https://pubmed.ncbi.nlm.nih.gov/26042494
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6
Eye Irritation Testing: The Way Forward. The Report and Recommendations of ECVAM Workshop 34
Autor: M, Balls, N, Berg, L H, Bruner, R D, Curren, O, de Silva, L K, Earl, D J, Esdaile, J H, Fentem, M, Liebsch, Y, Ohno, M K, Prinsen, H, Spielmann, A P, Worth
Publikováno v: Alternatives to laboratory animals : ATLA. 27(1)
This is the report of the thirty-fourth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM's main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scienti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d88eb6c242e1d742cfb602e4ed28a912
https://pubmed.ncbi.nlm.nih.gov/25423402
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7
Validation-Lessons learned from practical experience
Autor: J H, Fentem, M K, Prinsen, H, Spielmann, E, Walum, P A, Botham
Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 9(6)
With regard to the problems encountered and the experience gained in validation studies conducted in the past, suggestions have been made concerning criteria for the selection of the tests and laboratories to be included in a validation study, the se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be91336b646f39e63d54ffc55f61a050
https://pubmed.ncbi.nlm.nih.gov/20650167
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8
Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures
Autor: Jeffrey R. Fry, J. H. Fentem, A. H. Hammond
Publikováno v: Xenobiotica. 21:1363-1370
1. Hepatocytes were isolated from untreated and phenobarbitone (PB)-treated Mongolian gerbils by lobe perfusion. Yields were approx. 20 x 10(6) cells/g liver and viability was 95 +/- 1%. 2. PB treatment significantly increased the total cytochrome P-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bf4bcb23e8dca50c9ff9d13281b196
https://doi.org/10.3109/00498259109043211
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9
A prevalidation study on in vitro tests for acute skin irritation. results and evaluation by the Management Team
Autor: J H, Fentem, D, Briggs, C, Chesné, G R, Elliott, J W, Harbell, J R, Heylings, P, Portes, R, Roguet, J J, van de Sandt, P A, Botham
Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 15(1)
A prevalidation study on in vitro tests for acute skin irritation was conducted during 1999 and 2000. The overall objective of validation in this area, of which this prevalidation study is an initial stage, is to identify tests capable of discriminat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5b2ffcdb97a8c0abdf9e36c49fe53c1
https://pubmed.ncbi.nlm.nih.gov/11259870
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