Zobrazeno 1 - 10
of 1 795
pro vyhledávání: '"J. H. Duncan"'
Autor:
Scott E. Youlten, John P. Kemp, John G. Logan, Elena J. Ghirardello, Claudio M. Sergio, Michael R. G. Dack, Siobhan E. Guilfoyle, Victoria D. Leitch, Natalie C. Butterfield, Davide Komla-Ebri, Ryan C. Chai, Alexander P. Corr, James T. Smith, Sindhu T. Mohanty, John A. Morris, Michelle M. McDonald, Julian M. W. Quinn, Amelia R. McGlade, Nenad Bartonicek, Matt Jansson, Konstantinos Hatzikotoulas, Melita D. Irving, Ana Beleza-Meireles, Fernando Rivadeneira, Emma Duncan, J. Brent Richards, David J. Adams, Christopher J. Lelliott, Robert Brink, Tri Giang Phan, John A. Eisman, David M. Evans, Eleftheria Zeggini, Paul A. Baldock, J. H. Duncan Bassett, Graham R. Williams, Peter I. Croucher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Osteocytes are the master regulatory cells within the skeleton. Here, the authors map the transcriptome of osteocytes from diverse skeletal sites, ages and between sexes and identify an osteocyte transcriptome signature associated with rare skeletal
Externí odkaz:
https://doaj.org/article/60182d9a653b4b4d9d0b7b34378bcb3e
Autor:
Julia Steinberg, Lorraine Southam, Theodoros I. Roumeliotis, Matthew J. Clark, Raveen L. Jayasuriya, Diane Swift, Karan M. Shah, Natalie C. Butterfield, Roger A. Brooks, Andrew W. McCaskie, J. H. Duncan Bassett, Graham R. Williams, Jyoti S. Choudhary, J. Mark Wilkinson, Eleftheria Zeggini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Understanding the molecular effects of disease variants in relevant tissues is essential to understanding and treating disease. Here, the authors discover expression and protein quantitative trait loci in cartilage and synovium from 115 osteoarthriti
Externí odkaz:
https://doaj.org/article/dcec7e1450ec48c58e6b36aa6fd093ff
Autor:
Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S. Mannan, Anne-Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena Ghirardello, Lorraine Southam, Scott E. Youlten, J. Mark Wilkinson, Elizabeth A. McAninch, Valerie E. Vancollie, Fiona Kussy, Jacqueline K. White, Christopher J. Lelliott, David J. Adams, Richard Jacques, Antonio C. Bianco, Alan Boyde, Eleftheria Zeggini, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Osteoarthritis is a chronic, heritable disease with no available treatment. Here, the authors show that a validated, rapid-throughput joint phenotyping pipeline detects osteoarthritis in the mouse knee following surgical provocation, in aging and aft
Externí odkaz:
https://doaj.org/article/edbe1f565dfb4cb59b5b96ecd707f7bc
Autor:
Ines Foessl, J. H. Duncan Bassett, Åshild Bjørnerem, Björn Busse, Ângelo Calado, Pascale Chavassieux, Maria Christou, Eleni Douni, Imke A. K. Fiedler, João Eurico Fonseca, Eva Hassler, Wolfgang Högler, Erika Kague, David Karasik, Patricia Khashayar, Bente L. Langdahl, Victoria D. Leitch, Philippe Lopes, Georgios Markozannes, Fiona E. A. McGuigan, Carolina Medina-Gomez, Evangelia Ntzani, Ling Oei, Claes Ohlsson, Pawel Szulc, Jonathan H. Tobias, Katerina Trajanoska, Şansın Tuzun, Amina Valjevac, Bert van Rietbergen, Graham R. Williams, Tatjana Zekic, Fernando Rivadeneira, Barbara Obermayer-Pietsch
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE (“GEnomics of MusculoSkeletal Traits translational Network”) Working Group 2
Externí odkaz:
https://doaj.org/article/f56aa12424184b2093ef7db929b89a6f
Autor:
Melissa M. Formosa, Dylan J. M. Bergen, Celia L. Gregson, Antonio Maurizi, Anders Kämpe, Natalia Garcia-Giralt, Wei Zhou, Daniel Grinberg, Diana Ovejero Crespo, M. Carola Zillikens, Graham R. Williams, J. H. Duncan Bassett, Maria Luisa Brandi, Luca Sangiorgi, Susanna Balcells, Wolfgang Högler, Wim Van Hul, Outi Mäkitie
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Genetic disorders of the skeleton encompass a diverse group of bone diseases differing in clinical characteristics, severity, incidence and molecular etiology. Of particular interest are the monogenic rare bone mass disorders, with the underlying gen
Externí odkaz:
https://doaj.org/article/c40099a1d4c14c6b8b27c337b7001312
Autor:
Anna L Swan, Christine Schütt, Jan Rozman, Maria Del Mar Muñiz Moreno, Stefan Brandmaier, Michelle Simon, Stefanie Leuchtenberger, Mark Griffiths, Robert Brommage, Piia Keskivali-Bond, Harald Grallert, Thomas Werner, Raffaele Teperino, Lore Becker, Gregor Miller, Ala Moshiri, John R Seavitt, Derek D Cissell, Terrence F Meehan, Elif F Acar, Christopher J Lelliott, Ann M Flenniken, Marie-France Champy, Tania Sorg, Abdel Ayadi, Robert E Braun, Heather Cater, Mary E Dickinson, Paul Flicek, Juan Gallegos, Elena J Ghirardello, Jason D Heaney, Sylvie Jacquot, Connor Lally, John G Logan, Lydia Teboul, Jeremy Mason, Nadine Spielmann, Colin McKerlie, Stephen A Murray, Lauryl M J Nutter, Kristian F Odfalk, Helen Parkinson, Jan Prochazka, Corey L Reynolds, Mohammed Selloum, Frantisek Spoutil, Karen L Svenson, Taylor S Vales, Sara E Wells, Jacqueline K White, Radislav Sedlacek, Wolfgang Wurst, K C Kent Lloyd, Peter I Croucher, Helmut Fuchs, Graham R Williams, J H Duncan Bassett, Valerie Gailus-Durner, Yann Herault, Ann-Marie Mallon, Steve D M Brown, Philipp Mayer-Kuckuk, Martin Hrabe de Angelis, IMPC Consortium
Publikováno v:
PLoS Genetics, Vol 16, Iss 12, p e1009190 (2020)
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a ran
Externí odkaz:
https://doaj.org/article/14895730ccd5432c954b9d406684a8d3
Autor:
Hönes, G. Sebastian, Rakov, Helena, Logan, John, Liao, Xiao-Hui, Werbenko, Eugenie, Pollard, Andrea S., Præstholm, Stine M., Siersbæk, Majken S., Rijntjes, Eddy, Gassen, Janina, Latteyer, Sören, Engels, Kathrin, Strucksberg, Karl-Heinz, Kleinbongard, Petra, Zwanziger, Denise, Rozman, Jan, Gailus-Durner, Valerie, Fuchs, Helmut, de Angelis, Martin Hrabe, Klein-Hitpass, Ludger, Köhrle, Josef, Armstrong, David L., Grøntved, Lars, Bassett, J. H. Duncan, Williams, Graham R., Refetoff, Samuel, Führer, Dagmar, Moeller, Lars C.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2017 Dec . 114(52), E11323-E11332.
Externí odkaz:
https://www.jstor.org/stable/26488816
Akademický článek
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Autor:
Kourosh Ahmadzadeh, Marie Pereira, Margot Vanoppen, Eline Bernaerts, Jeong‐Hun Ko, Tania Mitera, Christy Maksoudian, Bella B Manshian, Stefaan Soenen, Carlos D Rose, Graham R Williams, J H Duncan Bassett, Patrick Matthys, Carine Wouters, Jacques Behmoaras
Publikováno v:
EMBO Rep
Macrophages undergo plasma membrane fusion and cell multinucleation to form multinucleated giant cells (MGCs) such as osteoclasts in bone, Langhans giant cells (LGCs) as part of granulomas or foreign-body giant cells (FBGCs) in reaction to exogenous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56bbea4f523b4670ab9d0e6c9b5031dc
https://europepmc.org/articles/PMC10074087/
https://europepmc.org/articles/PMC10074087/
Autor:
Natalie C. Butterfield, Katherine F. Curry, Julia Steinberg, Hannah Dewhurst, Davide Komla-Ebri, Naila S. Mannan, Anne-Tounsia Adoum, Victoria D. Leitch, John G. Logan, Julian A. Waung, Elena Ghirardello, Lorraine Southam, Scott E. Youlten, J. Mark Wilkinson, Elizabeth A. McAninch, Valerie E. Vancollie, Fiona Kussy, Jacqueline K. White, Christopher J. Lelliott, David J. Adams, Richard Jacques, Antonio C. Bianco, Alan Boyde, Eleftheria Zeggini, Peter I. Croucher, Graham R. Williams, J. H. Duncan Bassett
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/011d4dfdfe5148b694dd7e45abb452e1