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Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice

Autor: Thierry Claudel, J. Gumhold, Claudia D. Fuchs, Guenter Haemmerle, Harald Koefeler, Hubert Scharnagl, Pooja Kumari, Tatjana Stojakovic, Emina Halilbasic, Marion J. Pollheimer, Dagmar Silbert, Michael Trauner

Publikováno v: Hepatology

Nonalcoholic fatty liver disease (NAFLD) is characterized by triglyceride (TG) accumulation and endoplasmic reticulum (ER) stress. Because fatty acids (FAs) may trigger ER stress, we hypothesized that the absence of adipose triglyceride lipase (ATGL/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdde9f1edf39f036b774607fffb18ced
https://doi.org/10.1002/hep.25601

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Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO?3 output

Autor: Aldo Roda, Frank J. Gonzalez, Dagmar Silbert, Peter Fickert, Mario Strazzabosco, Stefania Vecchiotti, Kristina Schoonjans, Michael Trauner, Thierry Claudel, J. Gumhold, Luciano Adorini, Anna Baghdasaryan

Publikováno v: Hepatology (Baltimore Md.)

Chronic cholangiopathies have limited therapeutic options and represent an important indication for liver transplantation. The nuclear farnesoid X receptor (FXR) and the membrane G protein-coupled receptor, TGR5, regulate bile acid (BA) homeostasis a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f4ff34fc5740753231d46b26081f03

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Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing Cholangitis

Autor: Emilio Casanova, Gernot Zollner, Peter Fickert, Valeria Poli, Harald Esterbauer, Doris Schneller, Jan-Wilhelm Kornfeld, Robert Eferl, Wolfgang Mikulits, Leander Blaas, Markus Mair, Andrea Fuchsbichler, Lukas Kenner, J. Gumhold, Monica Musteanu, Christian Schuster, Michael Trauner, Martin Bilban, Stefanie Tauber

Publikováno v: Gastroenterology. 138:2499-2508

Background & Aims Signal transducer and activator of transcription 3 (Stat3) is the main mediator of interleukin-6–type cytokine signaling required for hepatocyte proliferation and hepatoprotection, but its role in sclerosing cholangitis and other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869920ac7858dbc7dd91215f4b46407c
https://doi.org/10.1053/j.gastro.2010.02.049

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Imbalance of pro- and antifibrogenic genes and bile duct injury in murineSchistosoma mansoniinfection-induced liver fibrosis

Autor: Peter Fickert, Martha Charlotte Holtfreter, D. Riebold, Emil C. Reisinger, Dagmar Silbert, Andrea Fuchsbichler, Micha Loebermann, J. Gumhold, Cord Langner, Michael Trauner, Martina Sombetzki, Horst Nizze

Publikováno v: Tropical Medicine & International Health. 14:1418-1425

OBJECTIVES The murine model of Schistosoma mansoni infection is characterized by strong fibrosis and little hepatocellular injury. The objective of this study was to evaluate the potential link between hepatic schistosomiasis and bile duct injury in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c22d76264306bc6b5734c41018bc24de
https://doi.org/10.1111/j.1365-3156.2009.02387.x

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Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2−/− mice

Autor: Romina Fiorotto, Michael Trauner, Alan F. Hofmann, Kurt Zatloukal, Hanns-Ulrich Marschall, Uday Maitra, Mario Strazzabosco, Tarek Moustafa, Dagmar Silbert, Andrea Fuchsbichler, Cord Langner, Helmut Denk, J. Gumhold, Emina Halilbasic, Carlo Spirli, Peter Fickert

Publikováno v: Hepatology. 49:1972-1981

24-norursodeoxycholic acid (norUDCA), a side chain-modified ursodeoxycholic acid derivative, has dramatic therapeutic effects in experimental cholestasis and may be a promising agent for the treatment of cholestatic liver diseases. We aimed to better

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84ab9e991255fc269304f22da9023908
https://doi.org/10.1002/hep.22891

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Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice

Autor: Dagmar Silbert, Gerd Hörl, Cord Langner, Thierry Claudel, Emina Halilbasic, Tarek Moustafa, Peter Fickert, Michael Trauner, Andrea Fuchsbichler, J. Gumhold, Anna Baghdasaryan

Publikováno v: Liver International. 28:948-958

Background/Aims: Multidrug resistance protein 2 (Abcb4) gene knockout mice (Mdr2−/−) lack phosphatidylcholine (PC) excretion into bile and spontaneously develop sclerosing cholangitis, biliary fibrosis and hepatocellular carcinomas. We therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8464a37e9dbc6fae1034b9f02e59423d
https://doi.org/10.1111/j.1478-3231.2008.01758.x

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Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-α/β in the adaptive response to bile acids

Autor: Martin Wagner, J. Gumhold, Hanns-Ulrich Marschall, Peter Fickert, Emina Halilbasic, Helmut Denk, Gernot Zollner, Andrea Fuchsbichler, Tarek Moustafa, Michael Trauner, Dagmar Silbert

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 290:G923-G932

The bile acid receptor farnesoid X receptor (FXR) is a key regulator of hepatic defense mechanisms against bile acids. A comprehensive study addressing the role of FXR in the coordinated regulation of adaptive mechanisms including biosynthesis, metab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe8da98bfb960d8f2a875c49135cd13
https://doi.org/10.1152/ajpgi.00490.2005

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Fxr−/− mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids

Autor: J. Gumhold, Jan Sjövall, Martin Wagner, Hanns-Ulrich Marschall, Andrea Fuchsbichler, Dagmar Silbert, Karl Bodin, Michael Trauner, Gernot Zollner, Peter Fickert

Publikováno v: Journal of Lipid Research, Vol 47, Iss 3, Pp 582-592 (2006)

Farnesoid X receptor knockout (Fxr(-/-)) mice cannot upregulate the bile salt export pump in bile acid loading or cholestatic conditions. To investigate whether Fxr(-/-) mice differ in bile acid detoxification compared with wild-type mice, we perform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8552a02dbd1d25b8680fadfc12dc17ae
https://doi.org/10.1194/jlr.m500427-jlr200

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