Zobrazeno 1 - 10
of 464
pro vyhledávání: '"J. Grubbs"'
Autor:
Kirk J. Grubbs, Daniel S. May, Joseph A. Sardina, Renee K. Dermenjian, Thomas P. Wyche, Adrián A. Pinto-Tomás, Jon Clardy, Cameron R. Currie
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Humans use natural products to treat disease; similarly, some insects use natural products produced by Actinobacteria to combat infectious pathogens. Honey bees, Apis mellifera, are ecologically and economically important for their critical role as p
Externí odkaz:
https://doaj.org/article/74e16bc1184a49a0ac7d6ed1460273fa
Autor:
Kirk J. Grubbs, Frank Surup, Peter H. W. Biedermann, Bradon R. McDonald, Jonathan L. Klassen, Caitlin M. Carlson, Jon Clardy, Cameron R. Currie
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Symbiotic microbes help a myriad of insects acquire nutrients. Recent work suggests that insects also frequently associate with actinobacterial symbionts that produce molecules to help defend against parasites and predators. Here we explore a potenti
Externí odkaz:
https://doaj.org/article/98f14d6d218649e4ae39af2378ec49b8
Autor:
Marc G. Chevrette, Caitlin M. Carlson, Humberto E. Ortega, Chris Thomas, Gene E. Ananiev, Kenneth J. Barns, Adam J. Book, Julian Cagnazzo, Camila Carlos, Will Flanigan, Kirk J. Grubbs, Heidi A. Horn, F. Michael Hoffmann, Jonathan L. Klassen, Jennifer J. Knack, Gina R. Lewin, Bradon R. McDonald, Laura Muller, Weilan G. P. Melo, Adrián A. Pinto-Tomás, Amber Schmitz, Evelyn Wendt-Pienkowski, Scott Wildman, Miao Zhao, Fan Zhang, Tim S. Bugni, David R. Andes, Monica T. Pupo, Cameron R. Currie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Host microbiomes are feasible sources for drug discovery. Here, using large-scale isolations, bioactivity assays and omics, the authors uncover the antimicrobial potential of insect-associated Streptomyces and identify a compound, cyphomycin, active
Externí odkaz:
https://doaj.org/article/854e622dbc4346adb3d1e484ca48f081
Publikováno v:
PLoS Biology, Vol 18, Iss 4, p e3000220 (2020)
Many lines of evidence point to links between sleep regulation and energy homeostasis, but mechanisms underlying these connections are unknown. During Caenorhabditis elegans sleep, energetic stores are allocated to nonneural tasks with a resultant dr
Externí odkaz:
https://doaj.org/article/c9a5a252b0a34044a0c454a1d57783dd
Autor:
Venkatram R. Atigadda, Mahendra P. Kashyap, Zhengrong Yang, Debasish Chattopadhyay, Nathalia Melo, Rajesh Sinha, Olga V. Belyaeva, Chu-Fang Chou, Pi-Ling Chang, Natalia Y. Kedishvili, Clinton J. Grubbs, Matthew B. Renfrow, Donald D. Muccio, Craig A. Elmets, Mohammad Athar
Publikováno v:
J Med Chem
Compound 1 is a potent rexinoid that is highly effective in cancer chemoprevention but elevates serum triglycerides. In an effort to separate the lipid toxicity from the anticancer activity of 1, we synthesized four new analogs of rexinoid 1, of whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b40461637cc0f417346b98efcc6e89d
https://doi.org/10.1021/acs.jmedchem.2c00735
https://doi.org/10.1021/acs.jmedchem.2c00735
Autor:
Clinton J. Grubbs, Holly L. Nicastro, M. Margaret Juliana, Vernon E. Steele, Ann Bode, Chris Tucker, Stanley C. Gill, Kenneth K. Iwata, Eva Szabo, Ronald A. Lubet
PDF file - 50K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b233f12128b4729dad891b2d730d797
https://doi.org/10.1158/1940-6207.22523784.v1
https://doi.org/10.1158/1940-6207.22523784.v1
Autor:
Clinton J. Grubbs, Vernon E. Steele, Daniel L. Boring, M. Margaret Juliana, Lori Minasian, Jonathan White, Ann Bode, James M. Scheiman, Ronald A. Lubet
Effects on Final tumor Weights of Naproxen and/or Omeprazole, Compared to Control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8f1ac5631453f6335aae488334ebc2
https://doi.org/10.1158/1940-6207.22527252.v1
https://doi.org/10.1158/1940-6207.22527252.v1
Autor:
Ronald A. Lubet, Clinton J. Grubbs, Ann M. Bode, Weidong Wen, Peter T. Vedell, Pengyuan Liu, Zara Ghazoui, Ming You, Yan Lu
XLSX file - 87K, Gene Expression Changes Comparing Control Rat Tumors and Rat Tumors Treated with Vorozole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e727191223c872887148649c29b769a
https://doi.org/10.1158/1940-6207.22524285
https://doi.org/10.1158/1940-6207.22524285
Autor:
Ronald A. Lubet, Vernon E. Steele, Daniel Boring, Ginger L. Milne, Ming You, Yan Lu, Mi-Sung Kim, Ann M. Bode, M. Margaret Juliana, Clinton J. Grubbs, Holly L. Nicastro
PDF - 73K, Supplementary Table S1. Effects of Various NSAIDs on Urinary 11-α-hydroxy-9, 15-dioxo-2, 3, 4, 5-tetranor-prostane-1, 20-dioic acid (PGE-M) levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80de34b29ba96a7a0a87714ba8179fa9
https://doi.org/10.1158/1940-6207.22525359
https://doi.org/10.1158/1940-6207.22525359
Autor:
Priscilla A. Furth, Donald D. Muccio, Clinton J. Grubbs, Michael J. Pishvaian, Bhaskar V.S. Kallakury, Edgar S. Díaz-Cruz, M. Carla Cabrera
PDF file - 643K, Relative expression levels of Cdk1, Rbl1 and Cdc25a in 4- and 7-month-old mice before and after TAg down-regulation by doxycycline treatment for 14 days and in conjunction with treatment with PD0332991 for 10 days, UAB30 for 14 days,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fab4c28919e1a5c101a4fde8c129ac
https://doi.org/10.1158/1940-6207.22525134
https://doi.org/10.1158/1940-6207.22525134