Zobrazeno 1 - 10
of 53
pro vyhledávání: '"J. Graham Sharp"'
Autor:
Varun Kesherwani, Mamta Shukla, Don W. Coulter, J. Graham Sharp, Shantaram S. Joshi, Nagendra K. Chaturvedi
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-14 (2020)
Abstract Background Medulloblastoma (MB) is one of the most common malignant cancers in children. MB is primarily classified into four subgroups based on molecular and clinical characteristics as (1) WNT (2) Sonic-hedgehog (SHH) (3) Group 3 (4) Group
Externí odkaz:
https://doaj.org/article/aebfab7e45d04559b079a0f1131a8fd5
Autor:
Nagendra K. Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J. Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi, Don W. Coulter
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-11 (2019)
Abstract Background MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associated with aberrant MYC f
Externí odkaz:
https://doaj.org/article/4b9f30f86f1948bcab03585ebd8da971
Autor:
Don W. Coulter, Shantaram S. Joshi, Hamid Band, J. Graham Sharp, Timothy R. McGuire, Yutong Liu, Sutapa Ray, Erin M. McIntyre, Mamta Shukla, Varun Kesherwani, Connor N. Griggs, Matthew J. Kling, Nagendra K. Chaturvedi
1. Immunohistochemistry (IHC). 2.Histological (H&E) analysis of cerebellar tumors. 3.Magnetic resonance imaging (MRI).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46288832035d349411e4e8e505f0fc34
https://doi.org/10.1158/1535-7163.22521717.v1
https://doi.org/10.1158/1535-7163.22521717.v1
Autor:
Don W. Coulter, Shantaram S. Joshi, Hamid Band, J. Graham Sharp, Timothy R. McGuire, Yutong Liu, Sutapa Ray, Erin M. McIntyre, Mamta Shukla, Varun Kesherwani, Connor N. Griggs, Matthew J. Kling, Nagendra K. Chaturvedi
Table S1. The list of genes whose expression were positively and strongly correlated with MYC expression in Group 3 MB.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f72285a667fa28d53446b04e17ed382
https://doi.org/10.1158/1535-7163.22521714.v1
https://doi.org/10.1158/1535-7163.22521714.v1
Autor:
Don W. Coulter, Shantaram S. Joshi, Hamid Band, J. Graham Sharp, Timothy R. McGuire, Yutong Liu, Sutapa Ray, Erin M. McIntyre, Mamta Shukla, Varun Kesherwani, Connor N. Griggs, Matthew J. Kling, Nagendra K. Chaturvedi
Fig. S1. RNA-seq analysis between MYC vs non-MYC amplified MB cell lines. Fig. S2. Synergistic effects of OTX and mTOR inhibitors on MYC-amplified MB cell growth. Fig. S3. JQ1 chemosensitizes the MB cells. Fig. S4. Flow cytometry plots for cell cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdc3267b9789bf095806db5691580bf
https://doi.org/10.1158/1535-7163.22521720.v1
https://doi.org/10.1158/1535-7163.22521720.v1
Autor:
J. Graham Sharp, Shantaram S. Joshi, Matthew J. Kling, Timothy R. McGuire, Varun Kesherwani, Nagendra K. Chaturvedi, Don W. Coulter
Publikováno v:
Oncotarget
Intercellular communication between tumor cells within the hypoxic microenvironment promote aggressiveness and poor patient prognoses for reasons that remain unclear. Here we show that hypoxic Ewing's sarcoma (EWS) cells release exosomes that promote
Autor:
Nagendra K. Chaturvedi, Don W. Coulter, Mamta Shukla, Shantaram S. Joshi, Varun Kesherwani, J. Graham Sharp
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-14 (2020)
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-14 (2020)
Background Medulloblastoma (MB) is one of the most common malignant cancers in children. MB is primarily classified into four subgroups based on molecular and clinical characteristics as (1) WNT (2) Sonic-hedgehog (SHH) (3) Group 3 (4) Group 4. Molec
Autor:
Varun Kesherwani, Shukla, Mamta, Coulter, Don W., J. Graham Sharp, Shantaram S. Joshi, Nagendra K. Chaturvedi
Additional file 3.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a608b4ffce3940490ec5609cd6ee832
Autor:
Yutong Liu, J. Graham Sharp, Timothy R. McGuire, Sutapa Ray, Connor N. Griggs, Nagendra K. Chaturvedi, Don W. Coulter, Hamid Band, Erin M. McIntyre, Mamta Shukla, Shantaram S. Joshi, Matthew J. Kling, Varun Kesherwani
Publikováno v:
Molecular cancer therapeutics. 19(6)
The MYC oncogene is frequently amplified in patients with medulloblastoma, particularly in group 3 patients, who have the worst prognosis. mTOR signaling–driven deregulated protein synthesis is very common in various cancers, including medulloblast
Autor:
Varun Kesherwani, Shantaram S. Joshi, Nagendra K. Chaturvedi, J. Graham Sharp, Don W. Coulter, Timothy R. McGuire, Sutapa Ray, Matthew J. Kling
Publikováno v:
Oncotarget
// Nagendra K. Chaturvedi 1 , Matthew J. Kling 2 , Don W. Coulter 1 , Timothy R. McGuire 3 , Sutapa Ray 1 , Varun Kesherwani 4 , Shantaram S. Joshi 2 and J. Graham Sharp 2 1 Departments of Pediatrics, Hematology and Oncology, University of Nebraska M