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Akademický článek

Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats

Autor: Chelsea M Cary, Talia N Seymore, Dilpreet Singh, Kinal N Vayas, Michael J Goedken, Samantha Adams, Marianne Polunas, Vasanthi R Sunil, Debra L Laskin, Philip Demokritou, Phoebe A Stapleton

Publikováno v: Particle and Fibre Toxicology, Vol 20, Iss 1, Pp 1-14 (2023)

Abstract Background Exposure to micro- and nanoplastic particles (MNPs) in humans is being identified in both the indoor and outdoor environment. Detection of these materials in the air has made inhalation exposure to MNPs a major cause for concern.

Externí odkaz: https://doaj.org/article/42bbe059b984466a9ccc55920b70624f

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Akademický článek

Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications

Autor: Chelsea M. Cary, Glen M. DeLoid, Zhenning Yang, Dimitrios Bitounis, Marianne Polunas, Michael J. Goedken, Brian Buckley, Byron Cheatham, Phoebe A. Stapleton, Philip Demokritou

Publikováno v: Nanomaterials, Vol 13, Iss 4, p 720 (2023)

Recent studies in experimental animals found that oral exposure to micro- and nano-plastics (MNPs) during pregnancy had multiple adverse effects on outcomes and progeny, although no study has yet identified the translocation of ingested MNPs to the p

Externí odkaz: https://doaj.org/article/c33eed4e9afc480ba6b4c39a8f5707ec

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Akademický článek

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Gene-by-Environment Interaction of Bcrp−/− and Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition

Autor: Anika L. Dzierlenga, Hui Li, Michael J. Goedken, Anna Vildhede, Nathan J. Cherrington, John D. Clarke, Erica Toth

Publikováno v: Drug Metabolism and Disposition. 46:1478-1486

Disease progression to nonalcoholic steatohepatitis (NASH) has profound effects on the expression and function of drug-metabolizing enzymes and transporters, which provide a mechanistic basis for variable drug response. Breast cancer resistance prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3a6a53ecd6c68da9dbf30b36740b5d
https://doi.org/10.1124/dmd.118.082081

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Inhibin B Response to Testicular Toxicants Hexachlorophene, Ethane Dimethane Sulfonate, Di-(n-butyl)-phthalate, Nitrofurazone, DL-Ethionine, 17-alpha Ethinylestradiol, 2,5-Hexanedione, or Carbendazim Following Short-Term Dosing in Male Rats

Autor: Warren E. Glaab, Frank D. Sistare, Kara Pearson, Michael J. Goedken, Karsten Menzel, Zoltan Erdos, Louise Parks Saldutti

Publikováno v: Birth Defects Research Part B: Developmental and Reproductive Toxicology. 98:41-53

BACKGROUND: Inhibin B is a heterodimer glycoprotein that downregulates follicle-stimulating hormone and is produced predominantly by Sertoli cells. The potential correlation between changes in plasma Inhibin B and Sertoli cell toxicity was evaluated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8aa403a4a23f4835483375d5ea78b0
https://doi.org/10.1002/bdrb.21035

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Compensatory Induction of Liver Efflux Transporters in Response to ANIT-Induced Liver Injury Is Impaired in FXR-Null Mice

Autor: Curtis D. Klaassen, Yuji Tanaka, Yue Julia Cui, Michael J. Goedken, Lauren M. Aleksunes

Publikováno v: Toxicological Sciences. 110:47-60

Alpha-naphthyl isothiocyanate (ANIT) is a hepatotoxicant that produces acute intrahepatic cholestasis in rodents. Farnesoid X receptor (FXR) and pregnane X receptor (PXR) are two major bile acid sensors in liver. The purpose of this study was to char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12120af87779afd8b82f5e1652cec3ed
https://doi.org/10.1093/toxsci/kfp094

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Spontaneous and Age-Related Testicular Findings in Beagle Dogs

Autor: Roy L. Kerlin, Michael J. Goedken, Daniel Morton

Publikováno v: Toxicologic Pathology. 36:465-471

This study was conducted to characterize spontaneous testicular and epididymal microscopic findings in eighty control beagle dogs from toxicity studies. Hypospermatogenesis, characterized by randomly scattered missing spermatids and/or spermatocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a4bd1b1a55eb955523f690abdde3e6
https://doi.org/10.1177/0192623308315670

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Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

Autor: Michael J. Goedken, Nico van Rooijen, Sarah N. Campion, Nathan J. Cherrington, Lauren M. Aleksunes, José E. Manautou, George L. Scheffer, Rachel Johnson

Publikováno v: Campion, S N, Johnson, R, Aleksunes, L M, Goedken, M J, van Rooijen, N, Scheffer, G L, Cherrington, N J & Manautou, J E 2008, ' Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function ', American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 295, no. 2, pp. G294-G304 . https://doi.org/10.1152/ajpgi.00541.2007
American Journal of Physiology. Gastrointestinal and Liver Physiology, 295(2), G294-G304. American Physiological Society

During acetaminophen (APAP) hepatotoxicity, increased expression of multidrug resistance-associated proteins 2, 3, and 4 (Mrp2-4) occurs. Mrp4 is the most significantly upregulated transporter in mouse liver following APAP treatment. Although the exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df2aaa4b49e68859f7a61d03e0b0a25
https://doi.org/10.1152/ajpgi.00541.2007

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