Výsledky vyhledávání - "J. Gerry Everlof"

An amide-based sulfenamide prodrug of gamma secretase inhibitor BMS-708163 delivers parent drug from an oral conventional solid dosage form in male beagle dog

Autor: Ivar M. McDonald, Wang Nenghui, Victor R. Guarino, Kimberley A. Lentz, Richard E. Olson, Wendy Clarke, Roy Haskell, J. Gerry Everlof

Publikováno v: Bioorganicmedicinal chemistry letters. 30(3)

The objective of this Letter is to report the first (to our knowledge) in vivo proof of concept for a sulfenamide prodrug to orally deliver a poorly soluble drug containing a weakly-acidic NH–acid from a conventional solid dosage formulation. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dd39c1805268048faa33aa27a7d547
https://pubmed.ncbi.nlm.nih.gov/31870650

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Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-Dependent tumor necrosis factor-α antagonists

Autor: Carl P. Decicco, Meizhong Xu, Rui-Qin Liu, Yvonne C. Lo, Percy H. Carter, Lorin A. Thompson, James M. Trzaskos, Gengjie Yang, Andrew J. Tebben, J. Gerry Everlof, Paul Strzemienski, Peggy A. Scherle, Gregory D. Brown, Matthew E. Voss

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:533-538

Based on the realization that N-alkyl 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones are tumor necrosis factor-alpha antagonists, we discovered two additional classes of antagonists: 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones (via rational desig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18edecff53bec99dad04afa5713d30ef
https://doi.org/10.1016/s0960-894x(02)00941-1

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Polymorphism of Roxifiban

Autor: C. M. Foris, Shelley R. Rabel, G. Creston Campbell, Gregory A. Nemeth, Susan M. Rowe, Michael B. Maurin, J. Gerry Everlof, Rodney Vickery

Publikováno v: Journal of Pharmaceutical Sciences. 91:2599-2604

Roxifiban was found to exist in two polymorphic forms. The polymorphs were detected by X-ray powder diffraction and solid-state carbon nuclear magnetic resonance. A slight difference between the two polymorphs was also detected by isothermal microcal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eced34e748fdc6094b327cf22de55d9
https://doi.org/10.1002/jps.10078

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