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Akademický článek

A symbolic framework to obtain mid-fidelity models of flexible multibody systems with application to horizontal-axis wind turbines

Autor: E. Branlard, J. Geisler

Publikováno v: Wind Energy Science, Vol 7, Pp 2351-2371 (2022)

The article presents a symbolic framework (also called computer algebra program) that is used to obtain, in symbolic mathematical form, the linear and nonlinear equations of motion of a mid-fidelity multibody system including rigid and flexible bodie

Externí odkaz: https://doaj.org/article/2f3a3dce918c42979a81dbd75608e740

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Akademický článek

Rationale and design of the PRevention of cArdiac Dysfunction during Adjuvant breast cancer therapy (PRADA II) trial: a randomized, placebo-controlled, multicenter trial

Autor: A Mecinaj, G Gulati, SL Heck, E Holte, MW Fagerland, AI Larsen, E.S Blix, J Geisler, T Wethal, T Omland

Publikováno v: Cardio-Oncology, Vol 7, Iss 1, Pp 1-11 (2021)

Abstract Background Recent advances in the treatment algorithms of early breast cancer have markedly improved overall survival. However, anthracycline- and trastuzumab-associated cardiotoxicity may lead to dose-reduction or halt in potentially life-s

Externí odkaz: https://doaj.org/article/e19bb5df904d4453ad257ce1962e33a4

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Akademický článek

Guided Relaxation–Based Virtual Reality for Acute Postoperative Pain and Anxiety in a Pediatric Population: Pilot Observational Study

Autor: Vanessa A Olbrecht, Keith T O'Conor, Sara E Williams, Chloe O Boehmer, Gilbert W Marchant, Susan M Glynn, Kristie J Geisler, Lili Ding, Gang Yang, Christopher D King

Publikováno v: Journal of Medical Internet Research, Vol 23, Iss 7, p e26328 (2021)

BackgroundDistraction-based therapies, such as virtual reality (VR), have been used to reduce pain during acutely painful procedures. However, distraction alone cannot produce prolonged pain reduction to manage sustained postoperative pain. Therefore

Externí odkaz: https://doaj.org/article/dbbce138c0314b2291fda76871eb62b2

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Akademický článek

Guided relaxation-based virtual reality versus distraction-based virtual reality or passive control for postoperative pain management in children and adolescents undergoing Nuss repair of pectus excavatum: protocol for a prospective, randomised, controlled trial (FOREVR Peds trial)

Autor: Vanessa A Olbrecht, Sara E Williams, Keith T O’Conor, Chloe O Boehmer, Gilbert W Marchant, Susan M Glynn, Kristie J Geisler, Lili Ding, Gang Yang, Christopher D King

Publikováno v: BMJ Open, Vol 10, Iss 12 (2020)

Introduction Virtual reality (VR) offers an innovative method to deliver non-pharmacological pain management. Distraction-based VR (VR-D) using immersive games to redirect attention has shown short-term pain reductions in various settings. To create

Externí odkaz: https://doaj.org/article/1114e41a81a54df9bffaf8c8738c21dc

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Akademický článek

Patterns of genomic evolution in advanced melanoma

Autor: E. Birkeland, S. Zhang, D. Poduval, J. Geisler, S. Nakken, D. Vodak, L. A. Meza-Zepeda, E. Hovig, O. Myklebost, S. Knappskog, P. E. Lønning

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

As melanoma progresses, it evolves. Here, in advanced melanoma the authors study genomic evolution, highlighting trunk mutations dominated by the ultraviolet damage signature, common late truncal whole-genome duplication events, as well as selective

Externí odkaz: https://doaj.org/article/ffbb2b2a90434988a7693775c83b0b50

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Akademický článek

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome

Autor: Gabriel Balmus, Delphine Larrieu, Ana C. Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J. Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A. Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J. Adams, Stephen P. Jackson

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Hutchinson-Gilford Progeria Syndrome is characterized by premature aging with cardiovascular disease being the main cause of death. Here the authors show that inhibition of the NAT10 enzyme enhances cardiac function and fitness, and reduces age-relat

Externí odkaz: https://doaj.org/article/b33496fa8a17473f945f0a89142ec415

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Data from Sequential Gene Targeting to Make Chimeric Tumor Models with De Novo Chromosomal Abnormalities

Autor: Terence H. Rabbitts, Kenneth MacLennan, T. Neil Dear, Juan C. Cigudosa, Leah Khazin, Nicola J. Geisler, Hanif Ali, Tim Brend, Tomoyuki Tanaka, Jennifer S. Chambers

The discovery of chromosomal translocations in leukemia/lymphoma and sarcomas presaged a widespread discovery in epithelial tumors. With the advent of new-generation whole-genome sequencing, many consistent chromosomal abnormalities have been describ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfce18cb537779797ebbbd01059bcd6c
https://doi.org/10.1158/0008-5472.c.6505839

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