Zobrazeno 1 - 10
of 63
pro vyhledávání: '"J. Gary Meszaros"'
Autor:
Yeong-Renn Chen, Patrick T. Kang, Daniel J. Luther, J. Gary Meszaros, Vahagn Ohanyan, William M. Chilian, Chwen-Lih Chen
Publikováno v:
Journal of Molecular and Cellular Cardiology. 88:14-28
During heightened cardiac work, O2 consumption by the heart benefits energy production via mitochondria. However, some electrons leak from the respiratory chain and yield superoxide, which is rapidly metabolized into H2O2 by SOD2. To understand the s
Novel noncanonical regulation of soluble VEGF/VEGFR2 signaling by mechanosensitive ion channel TRPV4
Autor:
Anantha K Kanugula, Priya Midha, Ravi K. Adapala, J. Gary Meszaros, William M. Chilian, Holly C. Cappelli, Sailaja Paruchuri, Charles K. Thodeti
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(1)
VEGF signaling via VEGF receptor-2 (VEGFR2) is a major regulator of endothelial cell (EC) functions, including angiogenesis. Although most studies of angiogenesis focus on soluble VEGF signaling, mechanical signaling also plays a critical role. Here,
Autor:
Ashot Minasyan, Sailaja Paruchuri, Holly C. Cappelli, J. Gary Meszaros, Charles K. Thodeti, Ravi K. Adapala, Anantha K Kanugula
Publikováno v:
The FASEB Journal. 32
Autor:
Christian M. McShannic, Nicholas J. Baker, Charles K. Thodeti, Ashot Minasyan, Brian L. Hom, Ravi K. Adapala, Connie Gan, J. Gary Meszaros
Publikováno v:
The FASEB Journal. 32
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 306:H1032-H1040
Aminopeptidase-A (APA) is a less well-studied enzyme of the renin-angiotensin system. We propose that it is involved in cardiac angiotensin (ANG) metabolism and its pathologies. ANG-(1–7) can ameliorate remodeling after myocardial injury. The aims
Publikováno v:
Acta Pharmacologica Sinica. 34:342-351
Living high training low” (LHTL) is an exercise-training protocol that refers living in hypoxia stress and training at normal level of O2. In this study, we investigated whether LHTL caused physiological heart hypertrophy accompanied by changes of
Autor:
J. Gary Meszaros, William M. Chilian, Daniel J. Luther, Ravi K. Adapala, Sailaja Paruchuri, Charles K. Thodeti, Roslin J. Thoppil
Publikováno v:
Journal of Molecular and Cellular Cardiology. 54:45-52
The phenotypic switch underlying the differentiation of cardiac fibroblasts into hypersecretory myofibroblasts is critical for cardiac remodeling following myocardial infarction. Myofibroblasts facilitate wound repair in the myocardium by secreting a
Autor:
Charles K. Thodeti, Roslin J. Thoppil, Giacinta Guarini, John G. Kmetz, Derek S. Damron, Ian N. Bratz, Daniel J. DelloStritto, J. Gary Meszaros, Vahagn Ohanyan
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 303:H216-H223
We have previously shown transient receptor potential vanilloid subtype 1 (TRPV1) channel-dependent coronary function is compromised in pigs with metabolic syndrome (MetS). However, the mechanisms through which TRPV1 channels couple coronary blood fl
Autor:
Deepak Bhatia, Animesh Mandal, J. Gary Meszaros, Vahagn Ohanyan, Altaf S. Darvesh, Roslin J. Thoppil, Anupam Bishayee, Judit Hohmann, Erzsébet Háznagy-Radnai
Publikováno v:
Molecular Carcinogenesis. 52:304-317
Black currant fruits containing high amounts of anthocyanins are known to possess potent antioxidant and anti-inflammatory properties. We have previously reported that anthocyanin-rich black currant skin extract (BCSE) inhibits diethylnitrosamine (DE
Autor:
Ben R. Hodson, John C. Koshy, Patricia E. Shamhart, Daniel J. Luther, J. Gary Meszaros, Vahagn Ohanyan
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 297:E1147-E1153
Diabetic patients are prone to developing myocardial fibrosis and suffer from decreased wound healing capabilities. The purpose of this study was to determine whether diabetes alters cardiac fibroblast activity in the myocardium in a 6-wk streptozoto