Výsledky vyhledávání

Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of JNJ-38431055, a Novel GPR119 Receptor Agonist and Potential Antidiabetes Agent, in Healthy Male Subjects

Autor: P P Stein, L B Katz, P L Rothenberg, S R Vanapalli, J J Gambale, Nicole Vaccaro, Troy C. Sarich, L Xi, E Vets, David Polidori

Publikováno v: Clinical Pharmacology & Therapeutics. 90:685-692

The incidence of type 2 diabetes mellitus is increasing worldwide. Several G–protein–coupled receptor agonists are being studied for their efficacy as antidiabetes agents. JNJ–38431055 is a novel, potent, and orally available selective agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7f4bcd31a399af2adc165f15e01697
https://doi.org/10.1038/clpt.2011.169

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Evaluation of JNJ-26489112 in patients with photosensitive epilepsy: a placebo-controlled, exploratory study

Autor: Jeffrey S. Nye, Liwen Xi, Gahan Pandina, Jay J. Gambale, Dorothée G.A. Kasteleijn-Nolst Trenité, Suzette Girgis, John A. Moyer, Lisa Ford, Nicholas A. Di Prospero

Publikováno v: Epilepsy research. 108(4)

Summary Purpose To evaluate the activity of JNJ-26489112 in patients with photosensitive epilepsy and determine the doses that result in reduction or complete suppression of the intermittent photic stimulation (IPS) induced photoparoxysmal-EEG respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bddbee216eb8f6da456d6eb8f9898e9f
https://pubmed.ncbi.nlm.nih.gov/24560845

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Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes

Autor: Troy C. Sarich, L. Xi, P. L. Rothenberg, J. J. Gambale, L. B. Katz, P. P. Stein, N. Vaccaro, S. R. Vanapalli

Publikováno v: Diabetes, obesitymetabolism. 14(8)

Aim: G-protein coupled receptor agonists are currently under investigation for their potential utility in patients with type 2 diabetes mellitus (T2DM). The objective was to determine the pharmacokinetics, pharmacodynamics, safety and tolerability of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ac0eb6cef9abe8ac8c0cd080e49cda
https://pubmed.ncbi.nlm.nih.gov/22340428

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Singley oxygen in synthesis. Formation of antimycin A3 from an oxazole template

Autor: Ronald J. Gambale, Harry H. Wasserman

Publikováno v: Tetrahedron. 48:7059-7070

Antimycin A 3 has been synthesized using an oxazole template for constructing the framework of the dilactone. Formation of the nine-membered ring was accomplished by reaction of an ω-hydroxyl group with an activated carboxylate generated in the reac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3da87a175bcf74cc40114f8c12900c30
https://doi.org/10.1016/s0040-4020(01)88247-8

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Bioequivalence of an ezetimibe/simvastatin combination tablet and coadministration of ezetimibe and simvastatin as separate tablets in healthy subjects

Publikováno v: International journal of clinical pharmacology and therapeutics. 44(2)

Objective: To assess the bioequivalence of an ezetimibe/simvastatin (EZE/SIMVA) combination tablet compared to the coadministration of ezetimibe and simvastatin as separate tablets (EZE + SIMVA). Methods: In this open-label, randomized, 2-part, 2-per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1ee683f2bcf674ddd1e95bf73d58d2
https://pubmed.ncbi.nlm.nih.gov/16502768

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Oxazoles as masked activated carboxylates. Synthesis of (±)-di-O-methylcurvularin

Autor: Harry H. Wasserman, Ronald J. Gambale

Publikováno v: Tetrahedron Letters. 22:4849-4852

The dimethyl ether of the mold metabolite, curvularin, was synthesized by intramolecular esterification of an activated carboxylate derived from the photooxidation of an oxazole precursor.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ac36692be6bd057d72a6aab3682a08a
https://doi.org/10.1016/s0040-4039(01)92361-5

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Activated carboxylates from the photooxygenation of oxazoles

Autor: Ronald J. Gambale, Harry H. Wasserman, Mitchell J. Pulwer

Publikováno v: Tetrahedron. 37:4059-4067

Oxazoles may be used as masked forms of activated carboxylic acids since they readily form triamides on reaction with singlet oxygen. With 2-alkyl-4,5-diphenyloxazoles, the triamides formed on photooxygenation undergo selective nucleophilic attack at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::797360bbc9699eb9f713acfb56bb67e7
https://doi.org/10.1016/s0040-4020(01)93281-8

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Activated carboxylates from the photooxygenation of oxazoles. Application to the synthesis of recifeiolide and other macrocyclic lactones

Autor: Mitchell J. Pulwer, Harry H. Hassennan, Ronald J. Gambale

Publikováno v: Tetrahedron Letters. 22:1737-1740

The oxazole system may serve as a protecting group for the carboxyl function. The carboxylate is generated under the mild conditions of photooxygenation in high yield in the form of the reactive triamide. This reaction has been applied to the synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ca18d2462a3dcb24aee9d0cccf07b46
https://doi.org/10.1016/s0040-4039(01)90426-5

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