Zobrazeno 1 - 10
of 2 893
pro vyhledávání: '"J. GLASS"'
Autor:
Jason S. Wasserman, Bulat Faezov, Kishan R. Patel, Alison M. Kurimchak, Seren M. Palacio, David J. Glass, Holly Fowle, Brennan C. McEwan, Qifang Xu, Ziran Zhao, Lauren Cressey, Neil Johnson, James S. Duncan, Arminja N. Kettenbach, Roland L. Dunbrack, Xavier Graña
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The Ser/Thr protein phosphatase 2 A (PP2A) regulates the dephosphorylation of many phosphoproteins. Substrate recognition are mediated by B regulatory subunits. Here, we report the identification of a substrate conserved motif [RK]-V-x-x-[VI
Externí odkaz:
https://doaj.org/article/6e9017a5c5d34b82817862a82164f6a6
Autor:
John J. Krais, David J. Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G. Betsch, Andrea J. Bernhardy, Alice M. Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T. Pomerantz, Gaorav P. Gupta, Joseph R. Testa, Neil Johnson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Homologous recombination (HR)-deficiency induces a dependency on DNA polymerase theta (Polθ/Polq)-mediated end joining, and Polθ inhibitors (Polθi) are in development for cancer therapy. BRCA1 and BRCA2 deficient cells are thought to be s
Externí odkaz:
https://doaj.org/article/1134d3c423c24ee9b10823404374aee9
Autor:
Tiffany J. Glass, John A. Russell, Erin H. Fisher, Marziyeh Ostadi, Nanyumuzi Aori, Y. Eugene Yu, Nadine P. Connor
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
PurposeDown syndrome (DS) is a developmental disability associated with difficulties in deglutition. The adult Ts65Dn mouse model of DS has been previously shown to have differences in measures of swallowing compared with euploid controls. However, t
Externí odkaz:
https://doaj.org/article/ac021aaa1ff6465fa1bfcbcac54f1200
Autor:
Christina L. Gardner, Rebecca A. Erwin-Cohen, Bridget S. Lewis, Russell R. Bakken, Shelley P. Honnold, Pamela J. Glass, Crystal W. Burke
Publikováno v:
Methods and Protocols, Vol 7, Iss 3, p 42 (2024)
Venezuelan (VEE), eastern (EEE), and western (WEE) equine encephalitis viruses are encephalitic New World alphaviruses that cause periodic epizootic and epidemic outbreaks in horses and humans that may cause severe morbidity and mortality. Currently
Externí odkaz:
https://doaj.org/article/9adc199c54e243d488077b26024c26a5
Autor:
Tea Shavlakadze, Kun Xiong, Shawn Mishra, Corissa McEwen, Abhilash Gadi, Matthew Wakai, Hunter Salmon, Michael J. Stec, Nicole Negron, Min Ni, Yi Wei, Gurinder S. Atwal, Yu Bai, David J. Glass
Publikováno v:
Skeletal Muscle, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Background As a result of aging, skeletal muscle undergoes atrophy and a decrease in function. This age-related skeletal muscle weakness is known as “sarcopenia”. Sarcopenia is part of the frailty observed in humans. In order to discover
Externí odkaz:
https://doaj.org/article/a43926fa120c4d5db9e644d5c5986045
Publikováno v:
SSM - Mental Health, Vol 4, Iss , Pp 100281- (2023)
Externí odkaz:
https://doaj.org/article/a12be950be88475193efd2b168072f51
Autor:
Jimcy Platholi, Roberta Marongiu, Laibaik Park, Fangmin Yu, Garrett Sommer, Rena Weinberger, William Tower, Teresa A. Milner, Michael J. Glass
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Dementia is often characterized by age-dependent cerebrovascular pathology, neuroinflammation, and cognitive deficits with notable sex differences in risk, disease onset, progression and severity. Women bear a disproportionate burden of dementia, and
Externí odkaz:
https://doaj.org/article/08b853b7a9284138b3773081b9b062ca
Autor:
K. E. Blethen, S. A. Sprowls, T. A. Arsiwala, C. P. Wolford, D. M. Panchal, R. A. Fladeland, M. J. Glass, L. P. Dykstra, B. N. Kielkowski, J. R. Blackburn, C. J. Andrick, P. R. Lockman
Publikováno v:
Radiation Oncology, Vol 18, Iss 1, Pp 1-10 (2023)
Abstract Background Approximately 20% of all cancer patients will develop brain metastases in their lifespan. The standard of care for patients with multiple brain metastases is whole-brain radiation therapy, which disrupts the blood–brain barrier.
Externí odkaz:
https://doaj.org/article/7f08f2d0d5344a3e825d1f58f3ee88b2
Autor:
Dana J. Murdock, Ning Wu, Joseph S. Grimsby, Roberto A. Calle, Stephen Donahue, David J. Glass, Mark W. Sleeman, Robert J. Sanchez
Publikováno v:
Skeletal Muscle, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Background Sarcopenia is defined as age-related low muscle mass and function, and can also describe the loss of muscle mass in certain medical conditions, such as sarcopenic obesity. Sarcopenic obesity describes loss of muscle and function i
Externí odkaz:
https://doaj.org/article/4f56a81b31534134b1d3d6277a01fa08
Autor:
Marco S. Kaiser, Giulia Milan, Daniel J. Ham, Shuo Lin, Filippo Oliveri, Kathrin Chojnowska, Lionel A. Tintignac, Nitish Mittal, Christian E. Zimmerli, David J. Glass, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Exploring the relationship between mTORC1 and the ubiquitin-proteasome system, light is shed on the paradox between mTORC1-mediated muscle hypertrophy induced by PKB/Akt and the muscle atrophy induced by mTORC1 alone.
Externí odkaz:
https://doaj.org/article/f20a08691add485199dd53a06c8fd523