Zobrazeno 1 - 10
of 37
pro vyhledávání: '"J. G. Pickering"'
Publikováno v:
Medical Imaging: Digital Pathology
Analysis and morphological comparison of arteriolar and venular networks are essential to our understanding of multiple diseases affecting every organ system. We have developed and evaluated the first fully automatic software system for differentiati
Publikováno v:
Medical Imaging: Digital Pathology
Properties of the microvasculature that contribute to tissue perfusion can be assessed using immunohistochemistry on 2D histology sections. However, the vasculature is inherently 3D and the ability to measure and visualize the vessel wall components
Publikováno v:
Medical Imaging 2015: Digital Pathology.
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 19:1843-1851
Abstract —Angiotensin II is an established regulator of vascular tone and smooth muscle cell (SMC) growth. However, there are little data about its effect on collagen synthesis by SMCs and none regarding the mechanism of such an effect. We studied
Publikováno v:
Journal of Clinical Investigation. 101:1889-1898
Migration of smooth muscle cells (SMCs) and collagen synthesis by SMCs are central to the pathophysiology of vascular disease. Both processes can be induced shortly after vascular injury; however, a functional relationship between them has not been e
Autor:
J M Isner, Sigrid Nikol, Marianne Kearney, Berthold Höfling, J G Pickering, N Murakami, Guy Leclerc, Lawrence Weir
Publikováno v:
Atherosclerosis. 130:71-85
Intimal proliferation and functional changes involving vascular smooth muscle cells are key events in the development of atherosclerosis, including restenosis after percutaneous transluminal angioplasty. Nonmuscle myosin (NMM) is required for cytokin
Autor:
S. Sengupta, J. G. Pickering
Publikováno v:
Day 2 Tue, October 29, 2013.
Many oil and gas operators now see Digital Oilfield as a mature technology and yet there is still a broad spectrum of knowledge across the industry about what it is and how to derive a good return on investment. Much has been said about developing th
Autor:
Eric P van der Veer, Ruben G de Bruin, Adriaan O Kraaijeveld, Margreet R de Vries, Tonio Pera, Filip M Segers, Stella Trompet, Janine M van Gils, Marko K Roeten, Cora M Beckers, Peter J van Santbrink, Anique Janssen, Coen van Solingen, Jim Swildens, Hetty C de Boer, Ilze Bot, Erna A Peters, Mat Rousch, Merijn Doop, Martin Jan Schalij, Allard C van der Wal, Stehpane Richard, Theo J van Berkel, J. G Pickering, Pieter S Hiemstra, Marie Jose Goumans, Ton J Rabelink, Antoine A de Vries, Paul H Quax, J. W Jukema, Erik A Biessen, Anton Jan van Zonneveld
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33
In response to vascular injury, smooth muscle cells (VSMC) adopt a proliferative, synthetic hypocontractile phenotype. This phenotype switch is deemed instrumental in vascular remodeling in both health and disease. Here, we detail a decisive role for
Publikováno v:
Journal of Applied Physiology. 77:1935-1940
Our purpose was to examine the gas exchange response to exercise in heart transplant (HT) patients and to characterize the O2 uptake kinetics (tau VO2) during successive square-wave on-transients from loadless cycling to moderate exercise. We hypothe
Autor:
Douglas W. Losordo, Guy Leclerc, Jeffrey M. Isner, Satoshi Takeshita, Lawrence Weir, J G Pickering, J Jekanowski, Marianne Kearney, Dov Gal
Publikováno v:
Circulation. 89:785-792
BACKGROUND The development of molecular strategies for the treatment of restenosis has been hindered by low efficiencies of in vivo arterial transfection. Expression of intracellular marker proteins is generally evident in < 1% of vascular smooth mus