Výsledky vyhledávání - "J. G. Mchutchison"

Treatment strategies for hepatitis C: Making the best of limited options

Autor: W. S. WILKE, J. G. McHUTCHISON, Z. YOUNOSSI

Publikováno v: Cleveland Clinic Journal of Medicine. 67:476-480

Data from two recent major trials suggest that several changes in clinical practice would benefit hepatitis C patients, including viral genotyping to more accurately determine the duration of therapy, and timely RNA measurement to predict treatment r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c11fbec4d7139fb851880c7b064961
https://doi.org/10.3949/ccjm.67.7.476

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Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif

Autor: A Cerny, J G McHutchison, C Pasquinelli, M E Brown, M A Brothers, B Grabscheid, P Fowler, M Houghton, F V Chisari

Publikováno v: Scopus-Elsevier

The HLA class I-restricted cytotoxic T lymphocyte (CTL) response is a major defense mechanism in viral infections. It has been suggested that the CTL response may contribute to viral clearance and liver cell injury during hepatitis C virus (HCV) infe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d531e482e31201241e73aa6a1a9c25ac
https://doi.org/10.1172/jci117694

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Measurement of occult upper gastrointestinal tract blood loss: A direct comparison of radiochromium and haem-porphyrin assay techniques

Autor: J. G. McHUTCHISON, N. M. Lynch, D. J. B. St. John, D. Barraclough, Graeme P. Young

Publikováno v: Journal of Gastroenterology and Hepatology. 8:328-333

Faecal haem-porphyrin assay by the HemoQuant method has many practical advantages over the well-validated, radiochromium (51Cr-tagged red cell) method for measuring gastrointestinal blood loss. Because haem may be absorbed but the chronic ion is not,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea5e8bb38e9d840bf4ddf174374debfc
https://doi.org/10.1111/j.1440-1746.1993.tb01522.x

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Sex and age differences in lipid response to chronic infection with the hepatitis C virus in the United States National Health and Nutrition Examination Surveys

Autor: X Q, Lao, A, Thompson, J G, McHutchison, J J, McCarthy

Publikováno v: Journal of viral hepatitis. 18(8)

Low levels of serum lipids were reported in subjects chronically infected with the hepatitis C virus (HCV) and correlated with poorer clinical outcomes. Whether HCV 'hypo-lipidemia' is constant across age, sex and race has not been systematically exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::54da18e2662147edc493380d3408dc69
https://pubmed.ncbi.nlm.nih.gov/20642483

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Open-label, ascending dose, prospective cohort study evaluating the antiviral efficacy of Rosuvastatin therapy in serum and lipid fractions in patients with chronic hepatitis C

Autor: K, Patel, R, Jhaveri, J, George, G, Qiang, C, Kenedi, K, Brown, C, Cates, A, Zekry, H L, Tillmann, L, Elliott, R, Kilaru, J, Albrecht, A, Conrad, J G, McHutchison

Publikováno v: Journal of viral hepatitis. 18(5)

HMG CoA reductase inhibition suppresses in vitro HCV replication through depletion of cellular sterol proteins such as geranylgeraniol. Our aims were to prospectively evaluate the changes in serum and lipid fraction HCV RNA with Rosuvastatin in non-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4daaed48c9156f7dab28c53f4a530dce
https://pubmed.ncbi.nlm.nih.gov/20367801

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Clinical trial: interferon alpha-2b continuous long-term therapy vs. repeated 24-week cycles for re-treating chronic hepatitis C

Autor: J G, McHutchison, K, Patel, E R, Schiff, N, Gitlin, R E, Mur, G T, Everson, R L, Carithers, G L, Davis, P, Marcellin, M L, Shiffman, J, Harvey, J K, Albrecht

Publikováno v: Alimentary pharmacologytherapeutics. 27(5)

Treatment options are limited for patients with hepatitis C virus who do not experience sustained viral eradication with pegylated interferon and ribavirin therapy.To compare, in an open-label, randomized study, long-term continuous interferon alpha-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7a42eb1e52022bbbab9da4b790b55f54
https://pubmed.ncbi.nlm.nih.gov/18081733

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Review article: pharmacological approaches for the treatment of thrombocytopenia in patients with chronic liver disease and hepatitis C infection

Autor: N H, Afdhal, J G, McHutchison

Publikováno v: Alimentary pharmacologytherapeutics. 26

Patients with chronic liver disease and hepatitis C virus (HCV) frequently experience thrombocytopenia that complicates the management of their disease. Traditional therapy for thrombocytopenia consists of platelet transfusion, which can be associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b4b88c32153d2fab9086b435cb2f4da4
https://pubmed.ncbi.nlm.nih.gov/17958517

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The impact of interferon plus ribavirin on response to therapy in black patients with chronic hepatitis C. The International Hepatitis Interventional Therapy Group

Autor: J G, McHutchison, T, Poynard, S, Pianko, S C, Gordon, A E, Reid, J, Dienstag, T, Morgan, R, Yao, J, Albrecht

Publikováno v: Gastroenterology. 119(5)

Black patients with chronic hepatitis C have lower response rates than white patients to interferon monotherapy. The factors responsible for these differences are unknown, as is the impact of combination antiviral therapy on responsiveness among ethn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc66f840977dcfd80570755c52b5861c
https://pubmed.ncbi.nlm.nih.gov/11054390

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Measurement of serum hyaluronic acid in patients with chronic hepatitis C and its relationship to liver histology. Consensus Interferon Study Group

Autor: J G, McHutchison, L M, Blatt, M, de Medina, J R, Craig, A, Conrad, E R, Schiff, M J, Tong

Publikováno v: Journal of gastroenterology and hepatology. 15(8)

Chronic hepatitis C is a slowly progressing inflammatory disease of the liver that can lead to cirrhosis and its complications. Assessment of liver damage in hepatitis C has been primarily via histological evaluation. Liver biopsy, while useful in de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::920cbb26f87615c4ced9950fe3fa1c81
https://pubmed.ncbi.nlm.nih.gov/11022820

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