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Modulation of secretory leukoprotease inhibitor gene expression in human bronchial epithelial cells by phorbol ester

Autor: J G Hay, Kazuhisa Yoshimura, Ronald G. Crystal, M Maruyama, Chin-Shyan Chu

Publikováno v: Journal of Clinical Investigation. 94:368-375

Secretory leukoprotease inhibitor (SLPI), a 12-kD nonglycosylated serine antiprotease, helps to protect the epithelial surface of the airways from the destructive capacity of neutrophil elastase. Based on the recognition that SLPI levels can increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc96ddf9294fff6297809ad98a28317
https://doi.org/10.1172/jci117331

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Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease

Autor: Ronald G. Crystal, J. G. Hay, Claire Danel, Chin-Shyan Chu

Publikováno v: The American journal of physiology. 268(4 Pt 1)

The CC10 gene encodes the Clara cell 10-kDa protein, which is expressed in airway epithelial cells. Quantification of CC10 gene expression in freshly isolated human proximal airway epithelial cells demonstrated very high mRNA levels, approximately fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9afb390960865db20b80fa2384891254
https://pubmed.ncbi.nlm.nih.gov/7733299

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Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis

Autor: Andrea Mastrangeli, Steven L. Brody, Chin-Shyan Chu, H A Jaffe, Claire Danel, Melissa A. Rosenfeld, J. G. Hay, N. T. Eissa, Ronald G. Crystal, Noel G. McElvaney

Publikováno v: Nature genetics. 8(1)

We have administered a recombinant adenovirus vector (AdCFTR) containing the normal human CFTR cDNA to the nasal and bronchial epithelium of four individuals with cystic fibrosis (CF). We show that this vector can express the CFTR cDNA in the CF resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635019f1b056f4480d278697ae9652bf
https://pubmed.ncbi.nlm.nih.gov/7527272

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Oxygen desaturation and breathlessness during corridor walking in chronic obstructive pulmonary disease: effect of oxitropium bromide

Autor: J. Carter, D. P. S. Spence, Pma Calverley, J. G. Hay, Michael Pearson

Publikováno v: Thorax. 48(11)

BACKGROUND--Although exercise induced desaturation can occur in patients with chronic obstructive pulmonary disease (COPD), little is known about its frequency during everyday exercise, or how it relates to dyspnoea or prior drug treatment. METHODS--

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782e0f3f6c9324838d0060ac734ecd7b
https://pubmed.ncbi.nlm.nih.gov/8296259

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Bronchodilator reversibility, exercise performance and breathlessness in stable chronic obstructive pulmonary disease

Autor: J G, Hay, P, Stone, J, Carter, S, Church, A, Eyre-Brook, M G, Pearson, A A, Woodcock, P M, Calverley

Publikováno v: The European respiratory journal. 5(6)

Partial bronchodilator reversibility can be demonstrated in many patients with stable chronic obstructive pulmonary disease (COPD), but its relevance to exercise capacity and symptoms is uncertain. Previous data suggest that anticholinergic bronchodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::55237afbe091c0dde5ab50f2b1d2a921
https://pubmed.ncbi.nlm.nih.gov/1628722

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