Zobrazeno 1 - 10
of 25
pro vyhledávání: '"J. G. Collard"'
Publikováno v:
Biochemical pharmacology. 61(8)
The underlying mechanism of the antiproliferative effect of S (simvastatin), a HMG-CoA reductase inhibitor, in vascular smooth muscle cells (SMC) is still poorly understood. In the present study, we used synchronized human SMC, isolated from left int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b79f8d30b3f1b0803419052ff5a0ea4d
https://pubmed.ncbi.nlm.nih.gov/11286990
https://pubmed.ncbi.nlm.nih.gov/11286990
Publikováno v:
Methods in enzymology. 325
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8308e867c168a8ecd0c36b62abbb4b41
https://pubmed.ncbi.nlm.nih.gov/11036622
https://pubmed.ncbi.nlm.nih.gov/11036622
Publikováno v:
Methods in enzymology. 325
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b606a8de1c765ad3496112e5d2f9a8a
https://pubmed.ncbi.nlm.nih.gov/11036612
https://pubmed.ncbi.nlm.nih.gov/11036612
Publikováno v:
The Journal of Cell Biology
Using biochemical assays to determine the activation state of Rho-like GTPases, we show that the guanine nucleotide exchange factor Tiam1 functions as a specific activator of Rac but not Cdc42 or Rho in NIH3T3 fibroblasts. Activation of Rac by Tiam1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d90091af922bb3c2ed5817c4bfa2d4b
https://pubmed.ncbi.nlm.nih.gov/10579721
https://pubmed.ncbi.nlm.nih.gov/10579721
Autor:
N, Geijsen, S, van Delft, J A, Raaijmakers, J W, Lammers, J G, Collard, L, Koenderman, P J, Coffer
Publikováno v:
Blood. 94(3)
The small guanosine triphosphate (GTPase) p21rac is highly expressed in human neutrophils where it is thought to play a role in cytoskeletal reorganization and superoxide production. Using the p21rac binding domain of PAK (PAK-RBD) as an activation-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59fa1fc05a5bc3ec62df14f496d3c616
https://pubmed.ncbi.nlm.nih.gov/10419906
https://pubmed.ncbi.nlm.nih.gov/10419906
Autor:
F, Michiels, J G, Collard
Publikováno v:
Biochemical Society symposium. 65
Metastasis formation is the leading cause of death in cancer patients. Using an in vitro model system, we have identified Tiam1 (T-lymphoma invasion and metastasis 1) as a gene that can induce invasion by and metastasis of mouse T-lymphoma cells. Sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbd5c6abea27dee2e158d7dd7ce1ee4c
https://pubmed.ncbi.nlm.nih.gov/10320937
https://pubmed.ncbi.nlm.nih.gov/10320937
Publikováno v:
Current topics in microbiology and immunology. 213
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2644e386dafcfc9378055e656ca08d5e
https://pubmed.ncbi.nlm.nih.gov/9053294
https://pubmed.ncbi.nlm.nih.gov/9053294
Publikováno v:
Oncogene. 11(11)
We have recently identified the invasion-inducing Tiam1 gene by proviral insertional mutagenesis. The Tiam1 protein shares a Dbl homology (DH) domain with an increasing number of oncoproteins, some of which have been shown to function as GDP dissocia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5bcd669c9b735201ec99bfede58e2fe5
https://pubmed.ncbi.nlm.nih.gov/8570171
https://pubmed.ncbi.nlm.nih.gov/8570171
Publikováno v:
Nature. 375(6529)
Rho-like GTPases have been implicated in the regulation of the actin cytoskeleton which controls the morphology, adhesion and motility of cells. Like Ras proteins, they become activated when bound GDP is exchanged for GTP, a process catalysed by GDP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5490d8a155f1956d8eaf1c4db5d708f6
https://pubmed.ncbi.nlm.nih.gov/7753201
https://pubmed.ncbi.nlm.nih.gov/7753201
Publikováno v:
Oncogene. 10(7)
By means of proviral tagging in combination with in vitro selection for invasive T-lymphoma variants, we have previously identified the murine invasion- and metastasis-inducing Tiam1 gene. Tiam1 encodes a novel protein which shares a Dbl-homology (DH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2cedc14abfab7e29a69971b38642b2f7
https://pubmed.ncbi.nlm.nih.gov/7731688
https://pubmed.ncbi.nlm.nih.gov/7731688