Zobrazeno 1 - 10
of 805
pro vyhledávání: '"J. Frazier"'
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
The development of medical countermeasures (MCMs) against organophosphate (OP) induced poisoning is of substantial importance. Use of conventional therapeutics is complicated by off-target effects and restricted penetration of the blood-brain barrier
Externí odkaz:
https://doaj.org/article/8c8e9dc495bb4ac88a2e30d724a954f5
Publikováno v:
Royal Society Open Science, Vol 11, Iss 6 (2024)
Host–microbiota interactions play a critical role in the hosts’ biology, and thus, it is crucial to elucidate the mechanisms that shape gut microbial communities. We leveraged threespine stickleback fish (Gasterosteus aculeatus) as a model system
Externí odkaz:
https://doaj.org/article/3d5fad11cadb4161a76071d5aae1a3b5
Autor:
Jeffrey S. Thinschmidt, Scott W. Harden, Michael A. King, James D. Talton, Charles J. Frazier
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (O
Externí odkaz:
https://doaj.org/article/3545c7d60f87475388b0638bb2d7565a
Autor:
Khalid Elsaafien, Scott W. Harden, Dominique N. Johnson, Aecha K. Kimball, Wanhui Sheng, Justin A. Smith, Karen A. Scott, Charles J. Frazier, Annette D. de Kloet, Eric G. Krause
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The brain maintains cardiovascular homeostasis, in part, via the arterial baroreflex which senses changes in blood pressure (BP) at the level of the aortic arch. Sensory afferents innervating the aortic arch employ baroreceptors to convert stretch ex
Externí odkaz:
https://doaj.org/article/0d05e03e04494f7ea60e27dbb7215a69
Autor:
Yuning Liu, Hong Xing, Wanhui Sheng, Kyle N. Singh, Alexandra G. Korkmaz, Caroline Comeau, Maisha Anika, Alexis Ernst, Fumiaki Yokoi, David E. Vaillancourt, Charles J. Frazier, Yuqing Li
Publikováno v:
Neurobiology of Disease, Vol 154, Iss , Pp 105342- (2021)
Dystonia is a neurological movement disorder characterized by sustained or intermittent muscle contractions, repetitive movement, and sometimes abnormal postures. DYT1 dystonia is one of the most common genetic dystonias, and most patients carry hete
Externí odkaz:
https://doaj.org/article/8236ce4e236641d7869644a27c28edb8
Publikováno v:
eLife, Vol 10 (2021)
Hypothalamic oxytocinergic magnocellular neurons have a fascinating ability to release peptide from both their axon terminals and from their dendrites. Existing data indicates that the relationship between somatic activity and dendritic release is no
Externí odkaz:
https://doaj.org/article/19dfdf9a26634505adf3a81dff24a0a3
Autor:
C.C. Bennett, M. Welton, J. Bos, G. Moon, A. Berkley, L. Kavlak, J. Pearson, G. Turabelidze, J. Frazier, N. Fehrenbach, C.K. Brown
Publikováno v:
Journal of Hospital Infection. 134:7-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b48a61a4f1075c92b12e2a4d6643918e
https://doi.org/10.1016/j.jhin.2022.12.022
https://doi.org/10.1016/j.jhin.2022.12.022
Autor:
Caesar M Hernandez, Caitlin A Orsini, Chase C Labiste, Alexa-Rae Wheeler, Tyler W Ten Eyck, Matthew M Bruner, Todd J Sahagian, Scott W Harden, Charles J Frazier, Barry Setlow, Jennifer L Bizon
Publikováno v:
eLife, Vol 8 (2019)
Across species, aging is associated with an increased ability to choose delayed over immediate gratification. These experiments used young and aged rats to test the role of the basolateral amygdala (BLA) in intertemporal decision making. An optogenet
Externí odkaz:
https://doaj.org/article/69ee7725cacd4768938b686075c7c79c
Autor:
Jack E. Pechac, Michael J. Frazier
Publikováno v:
Applied Physics Letters. 122
In this Letter, we consider the dynamics of a multi-stable metamaterial with an elastic substrate to realize a mechanical system within which the position of a transition wavefront can be precisely controlled and remotely determined. This ability is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7541a7f3ef34699321615d758600a885
https://doi.org/10.1063/5.0153438
https://doi.org/10.1063/5.0153438
Autor:
Zoltan Szallasi, Kent W. Mouw, Dávid Szüts, Eliezer M. Van Allen, Rita Lozsa, Søren Brunak, Gopa Iyer, Mary-Ellen Taplin, Jean-Bernard Lazaro, Jonathan E. Rosenberg, Elizabeth R. Plimack, Jean H. Hoffman-Censits, David B. Solit, James A. Rodrigues, Naresh Vasani, David Liu, David J. Konieczkowski, Zoë J. Frazier, Helle Pappot, Istvan Csabai, Orsolya Rusz, Sándor Spisák, Viktoria Tisza, Kasia M. Dillon, Amruta S. Samant, Miklos Diossy, Sizhi P. Gao, Raie Bekele, Zsofia Sztupinszki, Judit Börcsök
Purpose:Cisplatin-based chemotherapy is a first-line treatment for muscle-invasive and metastatic urothelial cancer. Approximately 10% of bladder urothelial tumors have a somatic missense mutation in the nucleotide excision repair (NER) gene, ERCC2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40cf5164db93a9406a97d86b4c8ee12a
https://doi.org/10.1158/1078-0432.c.6531189
https://doi.org/10.1158/1078-0432.c.6531189
