Výsledky vyhledávání

Data from Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

Autor: Margaret C. Frame, Tomi K. Sawyer, Chester A. Metcalf, Bryan Serrels, Valerie J. Fincham, Egle Avizienyte, Valerie G. Brunton

Src tyrosine kinase expression and activity are elevated during colon cancer progression. How this contributes to the malignant phenotype is not fully understood. We show that in KM12C colon carcinoma cells, expression of kinase-deficient Src protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0838a9b5dff6a28ae13383bd4f01cf71
https://doi.org/10.1158/0008-5472.c.6494636

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Implementation of an educational program to improve precepting skills

Autor: Sarah J Fincham, Janet Purath, Todd Smith

Publikováno v: Journal of the American Association of Nurse Practitioners. 33:331-337

Background Educating health care providers is dependent on developing high-quality clinical preceptors, yet preceptors face widespread challenges to precepting, such as time constraints and lack of formal preceptor training. Local problem Our college

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bdcf837e457a3f45bea084dd44277ed
https://doi.org/10.1097/jxx.0000000000000326

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Akademický článek

The Protrusive Phase and Full Development of Integrin-Dependent Adhesions in Colon Epithelial Cells Require FAK- and ERKMediated Actin Spike Formation: Deregulation in Cancer Cells

Autor: Valerie G. Brunton, Valerie J. Fincham, Gordon W. McLean, Steven J. Winder, Christos Paraskeva, John F. Marshall, Margaret C. Frame

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 3, Iss 3, Pp 215-226 (2001)

Integrins play an important role in tumour progression by influencing cellular responses and matrix-dependent adhesion. However, the regulation of matrix-dependent adhesion assembly in epithelial cells is poorly understood. We have investigated the i

Externí odkaz: https://doaj.org/article/39c456e9a74a45b589692b899b3c24d7

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Identification of Src-Specific Phosphorylation Site on Focal Adhesion Kinase: Dissection of the Role of Src SH2 and Catalytic Functions and Their Consequences for Tumor Cell Behavior

Autor: Chester A. Metcalf, Bryan Serrels, Margaret C. Frame, Tomi K. Sawyer, Valerie J. Fincham, Egle Avizienyte, Valerie G. Brunton

Publikováno v: Cancer Research. 65:1335-1342

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a8df33a791895c578940b2137834ac
https://doi.org/10.1158/0008-5472.can-04-1949

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Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors

Autor: Gary L. Grunewald, Kelcie J. Fincham, F. Anthony Romero, Seema R. Bhat, Kevin R. Criscione, Alex D. Chieu

Publikováno v: Bioorganic & Medicinal Chemistry. 13:1261-1273

A series of 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinolines was synthesized and these compounds were evaluated for their PNMT inhibitory potency and affinity for the α 2 -adrenoceptor. 7-Nitro-, 7-bromo-, 7-aminosulfonyl-, or 7- N -2,2,2-trifl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a169c14c251b09b0982204bcc5b4bbd0
https://doi.org/10.1016/j.bmc.2004.11.015

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