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Autor: J. Fichelle, G. Plassard, M.A. Thompson, Emmanuel Naline, S. Jouquey, P. Miller, J.L. Freslon, Charles Advenier

Publikováno v: Fundamental & Clinical Pharmacology. 2:525-540

The bronchodilator properties of RU 42173, a new beta-adrenergic stimulant with an original structure, as a cyclic analogue of an arylethanolamine, have been evaluated on different in vitro and in vivo models and compared with those of salbutamol and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f507cfec8758e2f23bfda5aa595dd8
https://doi.org/10.1111/j.1472-8206.1988.tb00653.x

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Comparison of the effects of the ace inhibitors trandolapril and enalapril on phlogogen induced foot pad oedema in the rat

Autor: Neil Leslie Brown, J. Fichelle, Manuel Worcel, S. Jouquey

Publikováno v: Agents and Actions. 24:297-302

Two angiotensin converting enzyme (ACE) inhibitors, trandolapril and enalapril, were compared for their effects on rat food-pad oedema induced by carrageenin, bradykinin, dextran and platelet activating factor (PAF). Trandolapril (0.03-30.0 mg/kg, pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f362a10f03a7093b0cdc09830ed29fe
https://doi.org/10.1007/bf02028286

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Cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 155)

Autor: J. Fichelle, J.R. Boissier, Henri Schmitt, Mme Hélène Schmitt, J.F. Giudicelli

Publikováno v: European Journal of Pharmacology. 2:333-339

The effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 155) have been investigated on the peripheral sympathetic system. ST 155 induced an initial rise in blood pressure in normal and reserpinized or adrenalectomized animals, a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae4b9c290b56c85064cfc21fb508ffd3
https://doi.org/10.1016/0014-2999(68)90183-0

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Angiotensin-converting enzyme inhibition, anti-hypertensive activity and hemodynamic profile of trandolapril (RU 44570)

Autor: Manuel Worcel, Neil Leslie Brown, J. Fichelle, Jean-Claude Vincent, Franck Benzoni, Marie-Yvonne Badel, Jacques Zanirato

Publikováno v: European journal of pharmacology. 148(1)

Trandolapril (RU 44570), a new non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor chemically related to enalapril, and its diacid (RU 44403), were investigated for their ability to inhibit angiotensin-converting enzyme. Trandolapril attenua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50466f2e6bb25369c82fe989139a1021
https://pubmed.ncbi.nlm.nih.gov/3383998

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Structure-activity relationship in PAF-acether. 4. Synthesis and biological activities of carboxylate isosteres

Autor: Françoise Heymans, Manuel Worcel, Jean Jacques Godfroid, Boguslaw Wichrowski, Simone Jouquey, J. Fichelle, C. Broquet

Publikováno v: Journal of medicinal chemistry. 31(2)

The synthesis and biological characterization of some 3-carboxylate isosteres of PAF-acether structurally modified in positions 1 (ether, carbamate), 2 (acetoyl, ethoxy), and 3 (chain length and polar head group) are reported. All derivatives present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2dbd9718130ecf3ff6f01f0e1a6c8a6
https://pubmed.ncbi.nlm.nih.gov/3339611

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