Zobrazeno 1 - 10
of 218
pro vyhledávání: '"J. Fialip"'
Autor:
Frédéric Libert, Anne-Sophie Wattiez, Loiodice S, Christine Courteix, Alain Eschalier, A.-M. Privat, J. Fialip
Publikováno v:
British Journal of Pharmacology. 163:792-803
BACKGROUND AND PURPOSE Antidepressants are one of the recommended treatments for neuropathic pain. However, their analgesic action remains unpredictable, and there are no selection criteria for clinical use. Better knowledge of their mechanism of act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f45112be42055b89c444c0378f6e8f2e
https://doi.org/10.1111/j.1476-5381.2011.01297.x
https://doi.org/10.1111/j.1476-5381.2011.01297.x
Publikováno v:
Journal of Pharmacy and Pharmacology. 53:1117-1123
A new series of N-substituted dioxo-imidazo[3,4-c]thiazoles have been prepared and evaluated for their analgesic activity. The structures of these new derivatives were confirmed by IR, 1H NMR and 13C NMR spectra, and by elemental analysis. When admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0017ec7004a62a07a4c6f65bc496d65
https://doi.org/10.1211/0022357011776504
https://doi.org/10.1211/0022357011776504
Publikováno v:
Brain Research. 887:239-249
This work describes a new animal model of neuropathic pain produced by the single intraperitoneal administration of Taxol (32 mg/kg) to male Sprague-Dawley rats. During the course of the experiment, the clinical status of the rats remained satisfacto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce94dd820ac1c40e2e3c928003dd35d
https://doi.org/10.1016/s0006-8993(00)02910-3
https://doi.org/10.1016/s0006-8993(00)02910-3
Publikováno v:
Pharmacy and Pharmacology Communications. 6:387-396
A new series of 4,6-diaryl pyridazin-3-ones substituted on the nitrogen atom in the 2-position have been prepared and evaluated for their analgesic activity in the phenylbenzo-quinone-induced abdominal constriction test. Most of the eighteen compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5666fed7c60eb232241cfb1035fbee07
https://doi.org/10.1211/146080800128736259
https://doi.org/10.1211/146080800128736259
Publikováno v:
Pharmacology Biochemistry and Behavior. 60:519-525
The aim of this study was to examine the role of dopamine neurotransmission in the effects of morphine in the learned helplessness paradigm in rats, a generally recognized model of depression. In this model, rats first exposed to inescapable shocks (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1a2fb7578a613b9104a13953f8b188
https://doi.org/10.1016/s0091-3057(98)00002-1
https://doi.org/10.1016/s0091-3057(98)00002-1
Publikováno v:
Pharmaceutical Biology. 36:280-286
Sedative activity of Juglans regia L. (Juglandaceae) chloroform extract and of one of its isolated constituents was evaluated in mice. Dry chloroform extract and juglone, orally administered at 6.5 mg/kg and 0.125 mg/kg, respectively, induced marked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c154608132f276e7417ff91ef9aab1
https://doi.org/10.1076/phbi.36.4.280.4580
https://doi.org/10.1076/phbi.36.4.280.4580
Publikováno v:
Life Sciences. 59:PL133-PL139
The antinociceptive effect of racemic tetrahydropapaveroline (THP), of its two R(+)- and S(-) enantiomers, of 1-2-dehydro-THP and of 1-carboxy-THP was assessed using different pain tests in mice. None of these drugs possessed a significant activity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdc2da124222bde4b736534b1acdb8c
https://doi.org/10.1016/0024-3205(96)00394-3
https://doi.org/10.1016/0024-3205(96)00394-3
Publikováno v:
General Pharmacology: The Vascular System. 27:215-219
The purposes of the present study were as follows: 1. 1. After an acute intraperitoneal (IP) administration of amitriptyline (AMI) to male Sprague-Dawley rats we found that: (i) its absorbtion rate is rapid; (ii) its elimination half-life is much sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c944bcc4e4ba4df0567de57aaf2bba61
https://doi.org/10.1016/0306-3623(95)02008-x
https://doi.org/10.1016/0306-3623(95)02008-x
Publikováno v:
Psychopharmacology. 123:71-78
The aim of this study was to investigate the possible involvement of the mu-opioid system on the learned-helplessness paradigm, an experimental model of depression, in rats. In this test, rats were first exposed to inescapable foot-shocks (IS); 48 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c10e6704940d1db20ee1734c096ef1
https://doi.org/10.1007/bf02246283
https://doi.org/10.1007/bf02246283
Publikováno v:
Fundamental & Clinical Pharmacology. 8:525-531
Kinetics of amitriptyline (AMI), its demethylated metabolites nortriptyline (NOR) and demethylnortriptyline (DM-NOR), and its hydroxylated metabolites, the E and Z isomers or 10-hydroxy-amitriptyline (E- and Z-10-OH-AMI) and of 10-hydroxynortriptylin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536c0cf8d2f7f7e1fd9c0231fc2af390
https://doi.org/10.1111/j.1472-8206.1994.tb00833.x
https://doi.org/10.1111/j.1472-8206.1994.tb00833.x