Zobrazeno 1 - 10
of 478
pro vyhledávání: '"J. Fertig"'
Autor:
Inês Godet, Harsh H. Oza, Yi Shi, Natalie S. Joe, Alyssa G. Weinstein, Jeanette Johnson, Michael Considine, Swathi Talluri, Jingyuan Zhang, Reid Xu, Steven Doctorman, Delma Mbulaiteye, Genevieve Stein-O’Brien, Luciane T. Kagohara, Cesar A. Santa-Maria, Elana J. Fertig, Daniele M. Gilkes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Hypoxia occurs in 90% of solid tumors and is associated with metastasis and mortality. Breast cancer cells that experience intratumoral hypoxia are 5x more likely to develop lung metastasis in animal models. Using spatial transcriptomics, we
Externí odkaz:
https://doaj.org/article/426e0d8a44dd43e7bc5d581380aed53f
Autor:
Hong Zhang, Riyue Bao, Song Liu, Mark Long, Sacha Gnjatic, Yi Xing, Elana J Fertig, Alan Hutson, Martin Morgan, Eytan Ruppin, Anant Madabhushi, Natalie Vokes, Daoud Meerzaman, Edgar Gonzalez-Kozlova, Vanessa D Jonsson, Eliezer M Van Allen, Spencer R Rosario, Jennifer Altreuter, Himangi Marathe, Jill S Barnholtz-Sloan, Lyndsay Harris, Qingrong Chen, James Dignam, Andrew J Gentles, Erika Kim, David Van Valen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 10 (2024)
Immuno-oncology has transformed the treatment of cancer, with several immunotherapies becoming the standard treatment across histologies. Despite these advancements, the majority of patients do not experience durable clinical benefits, highlighting t
Externí odkaz:
https://doaj.org/article/2a6c5ec863c6498aa1efe47fe6da43cb
Autor:
Joseph Bendik, Sandhya Kalavacherla, Nicholas Webster, Joseph Califano, Elana J. Fertig, Michael F. Ochs, Hannah Carter, Theresa Guo
Publikováno v:
BioMedInformatics, Vol 3, Iss 4, Pp 853-868 (2023)
Protein variation that occurs during alternative splicing has been shown to play a major role in disease onset and oncogenesis. Due to this, we have developed OutSplice, a user-friendly algorithm to classify splicing outliers in tumor samples compare
Externí odkaz:
https://doaj.org/article/16188fc4483c4eaaacb080fca45cf735
Autor:
Shuming Zhang, Long Yuan, Ludmila Danilova, Guanglan Mo, Qingfeng Zhu, Atul Deshpande, Alexander T. F. Bell, Jennifer Elisseeff, Aleksander S. Popel, Robert A. Anders, Elizabeth M. Jaffee, Mark Yarchoan, Elana J. Fertig, Luciane T. Kagohara
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-14 (2023)
Abstract Background Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about the inter- and intra-tumor heterogeneity i
Externí odkaz:
https://doaj.org/article/098a7d924d184c9b829632f226e3bd36
Autor:
Sahana Jayaraman, Janelle M. Montagne, Thomas R. Nirschl, Emily Marcisak, Jeanette Johnson, Amanda Huff, Meng-Hsuan Hsiao, Julie Nauroth, Thatcher Heumann, Jelani C. Zarif, Elizabeth M. Jaffee, Nilo Azad, Elana J. Fertig, Neeha Zaidi, H. Benjamin Larman
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 10, Pp 100600- (2023)
Summary: Assays linking cellular phenotypes with T cell or B cell antigen receptor sequences are crucial for characterizing adaptive immune responses. Existing methodologies are limited by low sample throughput and high cost. Here, we present INtraCE
Externí odkaz:
https://doaj.org/article/45d70b67a0e84bbe9759acdd360e9fa1
Autor:
Santiago D. Cárdenas, Constance J. Reznik, Ruchira Ranaweera, Feifei Song, Christine H. Chung, Elana J. Fertig, Jana L. Gevertz
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract The promise of precision medicine has been limited by the pervasive resistance to many targeted therapies for cancer. Inferring the timing (i.e., pre-existing or acquired) and mechanism (i.e., drug-induced) of such resistance is crucial for
Externí odkaz:
https://doaj.org/article/1199c17957c74b108d4b5b9e167bcb2a
Autor:
Yea Ji Jeong, Hildur Knutsdottir, Fatemeh Shojaeian, Michael G. Lerner, Maria F. Wissler, Elodie Henriet, Tammy Ng, Shalini Datta, Bernat Navarro-Serer, Peter Chianchiano, Benedict Kinny-Köster, Jacquelyn W. Zimmerman, Genevieve Stein-O’Brien, Matthias M. Gaida, James R. Eshleman, Ming-Tseh Lin, Elana J. Fertig, Andrew J. Ewald, Joel S. Bader, Laura D. Wood
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Pancreatic ductal adenocarcinoma (PDAC) frequently presents with metastasis, but the molecular programs in human PDAC cells that drive invasion are not well understood. Using an experimental pipeline enabling PDAC organoid isolation and collection ba
Externí odkaz:
https://doaj.org/article/877a49b959a144a8a641ca1dc42fec86
Publikováno v:
eLife, Vol 11 (2022)
Reduced-dimension or spatial in situ scatter plots are widely employed in bioinformatics papers analyzing single-cell data to present phenomena or cell-conditions of interest in cell groups. When displaying these cell groups, color is frequently the
Externí odkaz:
https://doaj.org/article/665b17edb6364d4c8423b4408fa59d04
Autor:
Emma Bigelow, Suchi Saria, Brian Piening, Brendan Curti, Alexa Dowdell, Roshanthi Weerasinghe, Carlo Bifulco, Walter Urba, Noam Finkelstein, Elana J Fertig, Alex Baras, Neeha Zaidi, Elizabeth Jaffee, Mark Yarchoan
Publikováno v:
Cancer Informatics, Vol 21 (2022)
Tumor mutational burden (TMB), a surrogate for tumor neoepitope burden, is used as a pan-tumor biomarker to identify patients who may benefit from anti-program cell death 1 (PD1) immunotherapy, but it is an imperfect biomarker. Multiple additional ge
Externí odkaz:
https://doaj.org/article/5bbf36839b37402ab474076c76e37c58
Autor:
Dimitrios N. Sidiropoulos, Genevieve L. Stein-O’Brien, Ludmila Danilova, Nicole E. Gross, Soren Charmsaz, Stephanie Xavier, James Leatherman, Hao Wang, Mark Yarchoan, Elizabeth M. Jaffee, Elana J. Fertig, Won Jin Ho
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Mass cytometry, or cytometry by TOF (CyTOF), provides a robust means of determining protein-level measurements of more than 40 markers simultaneously. While the functional states of immune cells occur along continuous phenotypic transitions, cytometr
Externí odkaz:
https://doaj.org/article/16cb3e58e1f7450682ee64a8668cb44a