Zobrazeno 1 - 10
of 340
pro vyhledávání: '"J. Feige"'
The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3
Autor:
Dorothea Höpfner, Adam Cichy, Vivian Pogenberg, Christoph Krisp, Soraya Mezouar, Nina C. Bach, Jan Grotheer, Sandra Madariaga Zarza, Eric Martinez, Matteo Bonazzi, Matthias J. Feige, Stephan A. Sieber, Hartmut Schlüter, Aymelt Itzen
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-25 (2023)
Abstract The intracellular bacterial pathogen Coxiella burnetii evades the host response by secreting effector proteins that aid in establishing a replication-friendly niche. Bacterial filamentation induced by cyclic AMP (Fic) enzymes can act as effe
Externí odkaz:
https://doaj.org/article/14d98f47b7b6442fbdefaf8c5d58cfd3
Autor:
Tejaswini Pradhan, Riddhiman Sarkar, Kevin M. Meighen-Berger, Matthias J. Feige, Martin Zacharias, Bernd Reif
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Systemic antibody light chain (AL) amyloidosis is characterized by deposition of amyloid fibrils. Prior to fibril formation, soluble oligomeric AL protein has a direct cytotoxic effect on cardiomyocytes. We focus on the patient derived λ-II
Externí odkaz:
https://doaj.org/article/16a00071844d4eef9149de55112ae2cc
Autor:
Joel Fauser, Burak Gulen, Vivian Pogenberg, Christian Pett, Danial Pourjafar-Dehkordi, Christoph Krisp, Dorothea Höpfner, Gesa König, Hartmut Schlüter, Matthias J. Feige, Martin Zacharias, Christian Hedberg, Aymelt Itzen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The ER chaperone BiP is critical for the unfolded protein response and tightly regulated through reversible AMPylation by FICD, but the structural basis is unknown. Here the authors use thiol-reactive nucleotide derivatives to stabilize the transient
Externí odkaz:
https://doaj.org/article/5b881075f8d343709870eb7b338a3da3
Autor:
Susanne Meier, Sina Bohnacker, Carolin J. Klose, Abraham Lopez, Christian A. Choe, Philipp W. N. Schmid, Nicolas Bloemeke, Florian Rührnößl, Martin Haslbeck, Julia Esser-von Bieren, Michael Sattler, Po-Ssu Huang, Matthias J. Feige
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
It is unclear how unassembled secretory pathway proteins are discriminated from misfolded ones. Here the authors combine biophysical and cellular experiments to study the folding of heterodimeric interleukin 23 and describe how ER chaperones recogniz
Externí odkaz:
https://doaj.org/article/7a8999f450d04116918a03d1d6abd258
Autor:
João P. L. Coelho, Matthias Stahl, Nicolas Bloemeke, Kevin Meighen-Berger, Carlos Piedrafita Alvira, Zai-Rong Zhang, Stephan A. Sieber, Matthias J. Feige
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
A fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined orientation of each transmembrane segment. Here, the authors show that mutations in connexin 32 can cause failures in membrane integration wh
Externí odkaz:
https://doaj.org/article/0f8fc492c9d64d8195722eb23af030af
Akademický článek
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Autor:
Nadia Alfaidy, Mohamed Benharouga, Jean J. Feige, Touria Aboussaouira, François Mallet, Philippe Sauthier, Aude Salomon, Pierre A. Bolze, Valentina Onnis, Gianfranco Balboni, Qun Y. Zhou, Mohammed Benlahfid, Pascale Hoffmann, Rima Slim, Sophie Brouillet, Houssine Boufettal, Frédéric Sergent, Wael Traboulsi
Supplemental Methods Figure S1: Reports clinical information's about normal pregnant women, patients with complete hydatiform moles or choriocarcinoma. Figure S2: Experimental procedure. Figure S3: Quantification of EG-VEGF PROKR1 and PROKR2 protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b45ec47753a52567d245f1c41698c3
https://doi.org/10.1158/1078-0432.22463115
https://doi.org/10.1158/1078-0432.22463115
Autor:
Nadia Alfaidy, Mohamed Benharouga, Jean J. Feige, Touria Aboussaouira, François Mallet, Philippe Sauthier, Aude Salomon, Pierre A. Bolze, Valentina Onnis, Gianfranco Balboni, Qun Y. Zhou, Mohammed Benlahfid, Pascale Hoffmann, Rima Slim, Sophie Brouillet, Houssine Boufettal, Frédéric Sergent, Wael Traboulsi
Purpose: Choriocarcinoma (CC) is the most malignant gestational trophoblastic disease that often develops from complete hydatidiform moles (CHM). Neither the mechanism of CC development nor its progression is yet characterized. We recently identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077632cc2184064cffcff323422a73b0
https://doi.org/10.1158/1078-0432.c.6525312
https://doi.org/10.1158/1078-0432.c.6525312
Autor:
Andrea Zanotti, João P. L. Coelho, Dinah Kaylani, Gurdeep Singh, Marina Tauber, Manuel Hitzenberger, Dönem Avci, Martin Zacharias, Robert B. Russell, Marius K. Lemberg, Matthias J. Feige
Publikováno v:
Science (New York, N.Y.). 378(6623)
Cells need to detect and degrade faulty membrane proteins to maintain homeostasis. In this study, we identify a previously unknown function of the human signal peptidase complex (SPC)—the enzyme that removes endoplasmic reticulum (ER) signal peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb1342bb70c0289f2e44fda26fe4eca
https://pubmed.ncbi.nlm.nih.gov/36454823
https://pubmed.ncbi.nlm.nih.gov/36454823
Autor:
Nicolas Bloemeke, Kevin Meighen‐Berger, Manuel Hitzenberger, Nina C Bach, Marina Parr, Joao PL Coelho, Dmitrij Frishman, Martin Zacharias, Stephan A Sieber, Matthias J Feige
Publikováno v:
The EMBO journalReferences. 41(24)
One-third of the human proteome is comprised of membrane proteins, which are particularly vulnerable to misfolding and often require folding assistance by molecular chaperones. Calnexin (CNX), which engages client proteins via its sugar-binding lecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7e73feae3727055a0aebe9d4d91fb9
https://pubmed.ncbi.nlm.nih.gov/36314723
https://pubmed.ncbi.nlm.nih.gov/36314723