Výsledky vyhledávání - "J. Fehrenbach"

A Single Nucleotide Polymorphism in

Autor: Matthew R, Alexander, Samuel, Hank, Bethany L, Dale, Lauren, Himmel, Xue, Zhong, Charles D, Smart, Daniel J, Fehrenbach, Yuhan, Chen, Nitin, Prabakaran, Brian, Tirado, Megan, Centrella, Mingfang, Ao, Liping, Du, Yu, Shyr, Daniel, Levy, Meena S, Madhur

Publikováno v: Circulation research. 131(9)

SH2B3 (SH2B adaptor protein 3) is an adaptor protein that negatively regulates cytokine signaling and cell proliferation. A common missense single nucleotide polymorphism inWe used CRISPR-Cas9 technology to create mice homozygous for the major (Arg/A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ec1c449b25f5da4d3d7921142c8d695
https://pubmed.ncbi.nlm.nih.gov/36169218

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A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage

Autor: Matthew R. Alexander, Samuel Hank, Bethany L. Dale, Lauren Himmel, Xue Zhong, Charles D. Smart, Daniel J. Fehrenbach, Yuhan Chen, Nitin Prabakaran, Brian Tirado, Megan Centrella, Mingfang Ao, Liping Du, Yu Shyr, Daniel Levy, Meena S. Madhur

Publikováno v: Circulation Research. 131:731-747

Background: SH2B3 (SH2B adaptor protein 3) is an adaptor protein that negatively regulates cytokine signaling and cell proliferation. A common missense single nucleotide polymorphism in SH2B3 (rs3184504) results in substitution of tryptophan (Trp) fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eda42aaef1275cc35f45497e9b0111f7
https://doi.org/10.1161/circresaha.121.320625

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Abstract 028: Toll-Like Receptor 4 Promotes Renal Immune Cell Infiltration And The Development Of Renal Damage During Dahl Salt-Sensitive Hypertension

Autor: Emily C Burns, Samuel Walton, John H Dasinger, Mary Shaw, Daniel J Fehrenbach, Aron M Geurts, Justine M Abais-Battad, David L Mattson

Publikováno v: Hypertension. 79

Previous work in our laboratory has implicated a significant role for the immune system in potentiating the hypertensive and kidney damage phenotypes which occur in the Dahl Salt-Sensitive (SS) rat. Toll-like receptors (TLRs), usually expressed on ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::369c82d8e9e9c1892979f6ab8ae72663
https://doi.org/10.1161/hyp.79.suppl_1.028

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Abstract P025: Cite-seq And Predixcan Analyses Identify Galectin-1 As A Potential Novel Mediator Of Heart Failure With Preserved Ejection Fraction In Mice And Humans

Autor: Jean W Wassenaar, Charles D Smart, Daniel J Fehrenbach, Matthew Dungan, Doran Amanda C, Megan M Shuey, Meena S Madhur

Publikováno v: Hypertension. 79

Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome where patients, despite having a normal left ventricular systolic function, present with symptoms of volume overload. Recent data have shown that HFpEF is associated with e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ec79918835df6a9b37ae871d61dac8b
https://doi.org/10.1161/hyp.79.suppl_1.p025

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Sexual Dimorphic Role of CD14 (Cluster of Differentiation 14) in Salt-Sensitive Hypertension and Renal Injury

Autor: David L. Mattson, Rebekah L. Gundry, John Henry Dasinger, Theodore Keppel, Hayley Lund, Jeylan Zemaj, Daniel J. Fehrenbach, Mary Cherian-Shaw, Justine M. Abais-Battad, Melinda R. Dwinell, Aron M. Geurts

Publikováno v: Hypertension. 77:228-240

Genomic sequence and gene expression association studies in animals and humans have identified genes that may be integral in the pathogenesis of various diseases. CD14 (cluster of differentiation 14)—a cell surface protein involved in innate immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae11cd7f8bfc652c9d8e4967bb3d91e5
https://doi.org/10.1161/hypertensionaha.120.14928

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Epigenetic Modifications in T Cells

Autor: Allen W. Cowley, Theodore A. Kotchen, Xiaoqing Pan, Srividya Kidambi, Justine M. Abais-Battad, Ammar J. Alsheikh, Pengyuan Liu, David L. Mattson, Hayley Lund, Mingyu Liang, John Henry Dasinger, Daniel J. Fehrenbach, Michelle L. Roberts

Publikováno v: Hypertension

The SS (Dahl salt sensitive) rat is an established model of hypertension and renal damage that is accompanied with immune system activation in response to a high-salt diet. Investigations into the effects of sodium-independent and dependent component

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d764a214f10e2d166322e389a3df1e
https://doi.org/10.1161/hypertensionaha.119.13716

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NOX2-derived reactive oxygen species in immune cells exacerbates salt-sensitive hypertension

Autor: Allen W. Cowley, David L. Mattson, Hayley Lund, John Henry Dasinger, Daniel J. Fehrenbach, Justine M. Abais-Battad

Publikováno v: Free Radic Biol Med

Previous studies utilizing the SSp67phox−/− rat have demonstrated the importance of systemic NADPH oxidase NOX2-derived reactive oxygen species (ROS) production in the pathogenesis of Dahl Salt-Sensitive (SS) hypertension and renal damage. It is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d3f6a2f34d4bcf50af3e51686ddf1b
https://doi.org/10.1016/j.freeradbiomed.2019.11.014

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