Zobrazeno 1 - 10
of 750
pro vyhledávání: '"J. Farrer"'
Autor:
Manuela M. X. Tan, Michael A. Lawton, Miriam I. Pollard, Emmeline Brown, Raquel Real, Alejandro Martinez Carrasco, Samir Bekadar, Edwin Jabbari, Regina H. Reynolds, Hirotaka Iwaki, Cornelis Blauwendraat, Sofia Kanavou, Leon Hubbard, Naveed Malek, Katherine A. Grosset, Nin Bajaj, Roger A. Barker, David J. Burn, Catherine Bresner, Thomas Foltynie, Nicholas W. Wood, Caroline H. Williams-Gray, Ole A. Andreassen, Mathias Toft, Alexis Elbaz, Fanny Artaud, Alexis Brice, Jean-Christophe Corvol, Jan Aasly, Matthew J. Farrer, Michael A. Nalls, Andrew B. Singleton, Nigel M. Williams, Yoav Ben-Shlomo, John Hardy, Michele T. M. Hu, Donald G. Grosset, Maryam Shoai, Lasse Pihlstrøm, Huw R. Morris
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract There are 90 independent genome-wide significant genetic risk variants for Parkinson’s disease (PD) but currently only five nominated loci for PD progression. The biology of PD progression is likely to be of central importance in defining
Externí odkaz:
https://doaj.org/article/b1dcf9f75c9e4bc4bc4699609e993749
Publikováno v:
Pathogens, Vol 13, Iss 11, p 974 (2024)
This narrative review examines infectious diseases as modifiable risk factors for dementia, particularly in the context of an aging global population. As the prevalence of Alzheimer’s disease and related dementias is expected to rise, prevention ha
Externí odkaz:
https://doaj.org/article/58e9cc60aac7437d9ad7c7f19fbf274d
Autor:
Mengfei Bu, Jordan Follett, Isaac Deng, Igor Tatarnikov, Shannon Wall, Dylan Guenther, Melissa Maczis, Genevieve Wimsatt, Austen Milnerwood, Mark S. Moehle, Habibeh Khoshbouei, Matthew J. Farrer
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Dysregulation of dopamine neurotransmission profoundly affects motor, motivation and learning behaviors, and can be observed during the prodromal phase of Parkinson’s disease (PD). However, the mechanism underlying these pathophysiological
Externí odkaz:
https://doaj.org/article/d7d5c549172147a4a35bf5c5e9f93f2c
Autor:
Fumitaka Kawakami, Motoki Imai, Yuki Isaka, Mark R. Cookson, Hiroko Maruyama, Makoto Kubo, Matthew J. Farrer, Makoto Kanzaki, Rei Kawashima, Tatsunori Maekawa, Shun Tamaki, Yoshifumi Kurosaki, Fumiaki Kojima, Kenichi Ohba, Takafumi Ichikawa
Publikováno v:
FEBS Open Bio, Vol 13, Iss 12, Pp 2200-2214 (2023)
Epidemiological studies have shown that abnormalities of glucose metabolism are involved in leucine‐rich repeat kinase 2 (LRRK2)‐associated Parkinson's disease (PD). However, the physiological significance of this association is unclear. In the p
Externí odkaz:
https://doaj.org/article/b45a9cfcdb4646e59fbb5d9ee09970be
Autor:
Amica C. Müller-Nedebock, Marieke C. J. Dekker, Matthew J. Farrer, Nobutaka Hattori, Shen-Yang Lim, George D. Mellick, Irena Rektorová, Mohamed Salama, Artur F. S. Schuh, A. Jon Stoessl, Carolyn M. Sue, Ai Huey Tan, Rene L. Vidal, Christine Klein, Soraya Bardien
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract The biological basis of the neurodegenerative movement disorder, Parkinson’s disease (PD), is still unclear despite it being ‘discovered’ over 200 years ago in Western Medicine. Based on current PD knowledge, there are widely varying t
Externí odkaz:
https://doaj.org/article/8ef87602d608417f925cb5814711f73b
Autor:
Carolin Gabbert, Susen Schaake, Theresa Lüth, Christoph Much, Christine Klein, Jan O. Aasly, Matthew J. Farrer, Joanne Trinh
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-8 (2023)
Abstract Background GBA1 variants are the strongest genetic risk factor for Parkinson’s disease (PD). However, the pathogenicity of GBA1 variants concerning PD is still not fully understood. Additionally, the frequency of GBA1 variants varies widel
Externí odkaz:
https://doaj.org/article/66c0687e8cf4413393014cc3043ff3b4
Publikováno v:
Brain Sciences, Vol 14, Iss 7, p 722 (2024)
Neurodegenerative disease is a major global health problem with 150 million people predicted to have dementia by 2050. Genetic factors, environmental factors, demographics, and some diseases have been associated with dementia. In addition to associat
Externí odkaz:
https://doaj.org/article/6cc7950496274652b3f6d36b4ca409c9
Publikováno v:
Pathogens, Vol 13, Iss 5, p 417 (2024)
A common infection, human cytomegalovirus (HCMV) has been associated with a variety of human diseases, including cardiovascular disease and possibly certain cancers. HCMV has also been associated with cognitive, psychiatric, and neurological conditio
Externí odkaz:
https://doaj.org/article/d5bc61b6dd074b04a079e8de173403b9
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
ObjectiveThe aim of this study was to systematically review the neuroimmunology literature to determine the average immune cell counts reported by flow cytometry in wild-type (WT) homogenized mouse brains.BackgroundMouse models of gene dysfunction ar
Externí odkaz:
https://doaj.org/article/bd5d9da6d2e747f4b1f7b455329c5d39
Autor:
Benjamin A. Christensen, Bradley Clark, Alexandra M. Muir, Whitney D. Allen, Erin M. Corbin, Tyshae Jaggi, Nathan Alder, Ann Clawson, Thomas J. Farrer, Erin D. Bigler, Michael J. Larson
Publikováno v:
Frontiers in Human Neuroscience, Vol 17 (2023)
IntroductionConcussion in children and adolescents is a public health concern with higher concussion incidence than adults and increased susceptibility to axonal injury. The corpus callosum is a vulnerable location of concussion-related white matter
Externí odkaz:
https://doaj.org/article/84141d636a9f4d078fc2cf34819025b4