Zobrazeno 1 - 10
of 34
pro vyhledávání: '"J. Farino"'
Publikováno v:
Journal of Biological Engineering, Vol 12, Iss 1, Pp 1-19 (2018)
Abstract Metastatic recurrence is a major hurdle to overcome for successful control of cancer-associated death. Residual tumor cells in the primary site, or disseminated tumor cells in secondary sites, can lie in a dormant state for long time periods
Externí odkaz:
https://doaj.org/article/41ddc4c25ba6465ebd497df06e528a74
Autor:
Stephanie E. Siegmund, Robert Grassucci, Stephen D. Carter, Emanuele Barca, Zachary J. Farino, Martí Juanola-Falgarona, Peijun Zhang, Kurenai Tanji, Michio Hirano, Eric A. Schon, Joachim Frank, Zachary Freyberg
Publikováno v:
iScience, Vol 6, Iss , Pp 83-91 (2018)
Summary: Mitochondrial diseases produce profound neurological dysfunction via mutations affecting mitochondrial energy production, including the relatively common Leigh syndrome (LS). We recently described an LS case caused by a pathogenic mutation i
Externí odkaz:
https://doaj.org/article/137763a45910469bb1a23c43d8e8d583
Autor:
Zachary Freyberg, Mark S. Sonders, Jenny I. Aguilar, Takato Hiranita, Caline S. Karam, Jorge Flores, Andrea B. Pizzo, Yuchao Zhang, Zachary J. Farino, Audrey Chen, Ciara A. Martin, Theresa A. Kopajtic, Hao Fei, Gang Hu, Yi-Ying Lin, Eugene V. Mosharov, Brian D. McCabe, Robin Freyberg, Kandatege Wimalasena, Ling-Wei Hsin, Dalibor Sames, David E. Krantz, Jonathan L. Katz, David Sulzer, Jonathan A. Javitch
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Amphetamines are known to enhance extracellular dopamine levels, but the underlying mechanisms are unclear. Utilising a new pH biosensor for synaptic vesicles, the authors show that amphetamines diminish vesicle pH gradients, disrupting dopamine pack
Externí odkaz:
https://doaj.org/article/3b8bfbbdbb454af19a8c38df694cd7dd
Akademický článek
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Autor:
Zachary J Farino, Travis J Morgenstern, Julie Vallaghe, Nathalie Gregor, Prashant Donthamsetti, Paul E Harris, Nicolas Pierre, Robin Freyberg, Fabienne Charrier-Savournin, Jonathan A Javitch, Zachary Freyberg
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148684 (2016)
Direct measurement of insulin is critical for basic and clinical studies of insulin secretion. However, current methods are expensive and time-consuming. We developed an insulin assay based on homogenous time-resolved fluorescence that is significant
Externí odkaz:
https://doaj.org/article/d5d1b9e483904f1da5f84e0c75cfd217
Publikováno v:
ACS Appl Bio Mater
Metastasis remains the leading cause of cancer-associated death worldwide. Disseminated tumor cells can undergo dormancy upon infiltration of secondary organs, and chemotherapeutics fail to effectively eliminate dormant populations. Mechanistic under
Autor:
Randall L. Duncan, Mallory Griffin, Jason P. Gleghorn, John H. Slater, Nicholas Trompeter, Ryan Skinner, Omar A. Banda, Cindy J. Farino
During the progression of osteoarthritis (OA), degradation of the extracellular matrix alters the biomechanical properties of cartilage, especially the compressive modulus. The mechanosensitive ion channel transient receptor potential vanilloid 4 (TR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50e8f20ca42ab1fba05e43edaa8f4c97
https://doi.org/10.1101/2021.09.14.460172
https://doi.org/10.1101/2021.09.14.460172
Publikováno v:
Adv Healthc Mater
We investigated the role of hydrogel properties (matrix adhesivity and degradability) in regulating the phenotypic fate of triple negative metastatic breast cancer using four cell lines: the MDA-MB-231 parental line and three organotropic sublines Bo
Autor:
Cindy J. Farino Reyes, John H. Slater
Publikováno v:
Adv Biol (Weinh)
Dormant, disseminated tumor cells (DTCs) can persist for decades in secondary tissues before being reactivated to form tumors. The properties of the premetastatic niche can influence DTC phenotype. To better understand how matrix properties of premet
Autor:
Nicholas Kravchenko, Cindy J. Farino, Nicholas Ramirez, Bhargava Nemmaru, John M. Yarbrough, Shishir P. S. Chundawat
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(3)
Dissociation of non-productively bound cellulolytic enzymes from cellulose is hypothesized to be a key rate-limiting factor impeding cost-effective biomass conversion to fermentable sugars. However, the role of carbohydrate-binding modules (CBMs) in