Výsledky vyhledávání - "J. F. Worzalla"

Synthesis of 4-Amino-8-(2, 2-Difluoro-2-Deoxy-β-D-Ribo Furanosyl Amino)Pyrimido [5, 4-D]Pyrimidine (dFARPP). Stability and Cellular Cytotoxicity

Autor: H. L. Pearce, J. M. Colacino, Chou Ta-Sen, C. D. Jones, T. E. Mabry, G. B. Grindey, J. F. Worzalla

Publikováno v: Nucleosides and Nucleotides. 13:1125-1133

The synthesis of β-dFARPP was accomplished by Mitsunobu coupling of 6-cyanopurine with 2-deoxy-2, 2-difluororibose followed by purine ring-expansion under the action of methanolic ammonia. The title compound inhibited the growth of proliferating hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::484699880d228ed1e5eddc7dcc437040
https://doi.org/10.1080/15257779408011883

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Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma

Autor: J L, Tonkinson, J F, Worzalla, C H, Teng, L G, Mendelsohn

Publikováno v: Cancer research. 59(15)

The proliferation rate of HT29 colon carcinoma cells was decreased by the multitargeted antifolate (MTA), LY231514. This effect correlated with a buildup of cells near the G1-S interface after 24 h of incubation, and a synchronized progression of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e0edf7625f45c3005fdee95f465579c2
https://pubmed.ncbi.nlm.nih.gov/10446980

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Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514

Autor: J F, Worzalla, C, Shih, R M, Schultz

Publikováno v: Anticancer research. 18(5A)

We studied the effects of folic acid on modulating the toxicity and antitumor efficacy of LY231514. Using several human tumor cell lines adapted to growth in low folate medium, folic acid was shown to be 100- to 1000-fold less active than folinic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c862f9f8ca9bb68de96262b9f072a265
https://pubmed.ncbi.nlm.nih.gov/9858888

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Role of Deoxycytidine Kinase (dCK), Thymidine Kinase 2 (TK2), and Deoxycytidine Deaminase (dCDA) in the Antitumor Activity of Gemcitabine (dFdC)

Autor: H.M. Pinedo, Judith R. Kroep, G. Veerman, Godefridus J. Peters, J. F. Worzalla, L. R. Tanzer, R. M. Schultz, C.J.A. van Moorsel, Ronald L. Merriman, D.A. Voorn

Publikováno v: Advances in Experimental Medicine and Biology ISBN: 9781461374565

Deoxycytidine kinase (dCK) and deaminase (dCDA) are as activating and inactivating enzymes, respectively, in the metabolism of several chemotherapeutically important deoxynucleoside analogues [1]. 2′2′-Difluorodeoxycytidine (dFdC; gemcitabine) ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d48f97b650e50bf8a9ab950e60b2cf74
https://doi.org/10.1007/978-1-4615-5381-6_127

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Sulfonimidamide analogs of oncolytic sulfonylureas

Autor: J E, Toth, G B, Grindey, W J, Ehlhardt, J E, Ray, G B, Boder, J R, Bewley, K K, Klingerman, S B, Gates, S M, Rinzel, R M, Schultz, L C, Weir, J F, Worzalla

Publikováno v: Journal of medicinal chemistry. 40(6)

A series of sulfonimidamide analogs of the oncolytic diarylsulfonylureas was synthesized and evaluated for (1) in vitro cytotoxicity against CEM cells, (2) in vivo antitumor activity against subaxillary implanted 6C3HED lymphosarcoma, and (3) metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::96793e7f0862b228f891d0bc4524e1f2
https://pubmed.ncbi.nlm.nih.gov/9083492

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Characterization of folate receptor from normal and neoplastic murine tissue: influence of dietary folate on folate receptor expression

Autor: S B, Gates, L G, Mendelsohn, K A, Shackelford, L L, Habeck, J D, Kursar, L S, Gossett, J F, Worzalla, C, Shih, G B, Grindey

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 2(7)

Membrane-associated folate receptors (FRs) have been detected in many mammalian species, and multiple isoforms have been identified. The pharmacological properties of FRs from murine kidney, liver, and six murine tumors were characterized. Murine kid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e351458dc56644c909c826976e41a81
https://pubmed.ncbi.nlm.nih.gov/9816279

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Augmentation of the therapeutic activity of lometrexol -(6-R)5,10-dideazatetrahydrofolate- by oral folic acid

Autor: T, Alati, J F, Worzalla, C, Shih, J R, Bewley, S, Lewis, R G, Moran, G B, Grindey

Publikováno v: Cancer research. 56(10)

Recent clinical trials with lometrexol [(6R)-5,10-dideazatetrahydrofolate] have revealed a level of toxicity in humans that was not predicted on the basis of previous in vivo preclinical studies. Because standard laboratory animal diets contain high

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d85bf4dba483e15c8ea43c1836c8c4e9
https://pubmed.ncbi.nlm.nih.gov/8625328

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Variability in safety information in U.S. Package Inserts (USPI) for anticancer agents

Autor: D. F. Roychowdhury, J. F. Worzalla, D. A. Rhein

Publikováno v: Journal of Clinical Oncology. 22:6068-6068

6068 Background: One purpose of PIs is to provide prescribers' with relevant safety information to make therapeutic decisions. We conducted a review of PIs for anti-cancer agents approved between 1...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f8cc21dd5e76414100ea4de8c2d65cf
https://doi.org/10.1200/jco.2004.22.90140.6068

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