Zobrazeno 1 - 10
of 30
pro vyhledávání: '"J. F. Thiercelin"'
Publikováno v:
Xenobiotica. 29:1017-1031
The disposition of tiludronate in mouse, rat, rabbit, dog and monkey has been studied after oral and intravenous doses. Like other bisphosphonates, tiludronate was characterized by poor absorption from the gastrointestinal tract. Peak plasma concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89a389c5c337ca60a2bdf086b185c16b
https://doi.org/10.1080/004982599238083
https://doi.org/10.1080/004982599238083
Autor:
J F Thiercelin
Publikováno v:
Fundamental & Clinical Pharmacology. 4:69s-76s
The aim of phase I studies per se is to explore the tolerance of new compounds which have demonstrated a certain level of activity in animals at sufficiently low non-toxic doses. In most cases, these studies are conducted in 2 steps in a limited numb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42460a781b3110f6d9f25d2e217a0643
https://doi.org/10.1111/j.1472-8206.1990.tb00064.x
https://doi.org/10.1111/j.1472-8206.1990.tb00064.x
Publikováno v:
Journal of Cardiovascular Pharmacology. 16:S31-S37
Among the antihypertensive agents, calcium antagonists and in particular diltiazem play a leading role. To improve the conditions of diltiazem administration in the treatment of hypertensive patients a galenic formulation allowing administration of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::623a640308da62c3196a7e0e5f3a323b
https://doi.org/10.1097/00005344-199000161-00007
https://doi.org/10.1097/00005344-199000161-00007
Autor:
P. A. M. Peeters, Jan H.G. Jonkman, H. R. Schwietert, J. Necciari, J. Dingemanse, J. F. Thiercelin, H. de Bruin
Publikováno v:
European journal of clinical pharmacology. 51(2)
A double-blind, placebo-controlled study was conducted to assess the pharmacokinetics and pharmacodynamics of the bisphosphonate tiludronic acid, administered once daily as sodium tiludronate 200, 400, 600 and 800 mg for 12 days. Four groups of ten s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb43feef8763ce5576850095281abb8
https://pubmed.ncbi.nlm.nih.gov/8911885
https://pubmed.ncbi.nlm.nih.gov/8911885
Publikováno v:
International journal of clinical pharmacology research. 12(1)
The following study explores the possibility that zolpidem, a new hypnotic agent derived from imidopyridine, may induce changes in ventilatory function in normal subjects. The study, conducted double-blind on 16 subjects (eight men and eight women, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::970f10ffda7480fd63d7b45a0daff4de
https://pubmed.ncbi.nlm.nih.gov/1526696
https://pubmed.ncbi.nlm.nih.gov/1526696
Autor:
G. Grasmeijer, Paolo L. Morselli, G. Bianchetti, J. P. Thenot, Ph. Guillet, B. Oosterhuis, Jan H.G. Jonkman, J. F. Thiercelin
Publikováno v:
European journal of clinical pharmacology. 41(4)
In a double-blind, placebo-controlled, cross-over experiment in 21 healthy male volunteers, aged 19 to 27 y, the pharmacokinetics and tolerance of the new anxiolytic drug alpidem (SL80.0342) and its three major metabolites were studied after single d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693a2e7e077994df56f57cf2518f9de4
https://pubmed.ncbi.nlm.nih.gov/1687121
https://pubmed.ncbi.nlm.nih.gov/1687121
Publikováno v:
Journal of cardiovascular pharmacology. 16
Among the antihypertensive agents, calcium antagonists and in particular diltiazem play a leading role. To improve the conditions of diltiazem administration in the treatment of hypertensive patients a galenic formulation allowing administration of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f69ea6b725e0815cd3bc227791dda53c
https://pubmed.ncbi.nlm.nih.gov/1706011
https://pubmed.ncbi.nlm.nih.gov/1706011
Publikováno v:
Psychopharmacology. 96:63-66
The combined use of a hypnotic and a neuroleptic is a rather frequent situation, encountered especially in the psychiatric sphere. We therefore tested zolpidem and chlorpromazine in six healthy subjects by using a double-blind latin square design. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578a6d4caaf2cca15b57163f7f41d782
https://doi.org/10.1007/bf02431534
https://doi.org/10.1007/bf02431534
Publikováno v:
Epilepsia. 28:68-73
The influence of progabide, a new antiepileptic drug, on the pharmacokinetic profiles of phenobarbital, phenytoin, carbamazepine, and valproic acid was evaluated in four separate studies, each including six young healthy volunteers. The pharmacokinet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b1282bb52d824b1f8b7b5aafcac899
https://doi.org/10.1111/j.1528-1157.1987.tb03625.x
https://doi.org/10.1111/j.1528-1157.1987.tb03625.x