Výsledky vyhledávání - "J. F. Stobaugh"

Mechanism Based Design of Amine Fluorogenic Derivatization Reagents: Proof of Concept, Physical–Chemical Characterization and Initial Analytical Derivatization Protocols

Autor: J. F. Stobaugh, S. C. Bernstein, L. L. McChesney-Harris, S. V. Kakodakar

Publikováno v: Chromatographia. 76:117-132

Herein, are described initial efforts in the design of a fluorogenic reagent applicable for the derivatization of primary and secondary amines. The initial reagent, 3-isothiocyanato-2-chloropyridine was based on physical–organic reactivity consider

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69e98cde012668f17c87e36a82c2d78f
https://doi.org/10.1007/s10337-012-2371-9

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Application of sulfobutylether-beta-cyclodextrin with specific degrees of substitution for the enantioseparation of pharmaceutical mixtures by capillary electrophoresis

Autor: D J, Skanchy, G H, Xie, R J, Tait, E, Luna, C, Demarest, J F, Stobaugh

Publikováno v: Electrophoresis. 20(13)

In this research the separation of the enantiomers of the basic drug bidisomide (SC-40230) from five closely related known process impurities was investigated using several neutral and anionic sulfobutylether beta-cyclodextrins (SBE-beta-CDs) as isom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b51bbac8b30643bb5176bc062a35c7b5
https://pubmed.ncbi.nlm.nih.gov/10532329

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Evaluation of 1.5 microM reversed phase nonporous silica in packed capillary electrochromatography and application in pharmaceutical analysis

Autor: P D, Angus, C W, Demarest, T, Catalano, J F, Stobaugh

Publikováno v: Electrophoresis. 20(12)

Reversed-phase nonporous silica (RP-NPS) of 1.5 microm dp is employed to demonstrate rapid and efficient separations in packed capillary electrochromatography (CEC). Two methods for packing capillaries and two techniques to manufacture frits used to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6bb911e6a57acd9a68ac79b2a455510
https://pubmed.ncbi.nlm.nih.gov/10499325

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Chiral separations of enantiomeric pharmaceuticals by capillary electrophoresis using sulphobutyl ether beta-cyclodextrin as isomer selector

Autor: G H, Xie, D J, Skanchy, J F, Stobaugh

Publikováno v: Biomedical chromatography : BMC. 11(4)

Capillary electrophoresis has developed into an extremely useful technique for the separation of optical isomers. High efficiencies and the availability of many types of isomer selectors allowing rapid and inexpensive methods development make capilla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ce34d06457883b045d3da98e72504dc
https://pubmed.ncbi.nlm.nih.gov/9256995

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Applications of capillary electrophoresis in pharmaceutical analysis

Autor: S R, Rabel, J F, Stobaugh

Publikováno v: Pharmaceutical research. 10(2)

The role of capillary electrophoresis (CE) in the analysis of peptide/proteins, chiral pharmaceuticals, and other small-molecule drugs has been reviewed. Potential uses of CE range from purity and structural confirmation to a micropreparative techniq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca12a036077aa336f0736753d5ffdfdc
https://pubmed.ncbi.nlm.nih.gov/8456063

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Stereoselective pharmacokinetics and metabolism of the enantiomers of cyclophosphamide. Preliminary results in humans and rabbits

Autor: K A, Holm, C G, Kindberg, J F, Stobaugh, M, Slavik, C M, Riley

Publikováno v: Biochemical pharmacology. 39(8)

[R(+),S(-)]-Cyclophosphamide [(R,S)-CP] is an anticancer drug, containing a chiral phosphorous atom, which is prepared and used clinically as the racemic mixture. A new high-performance liquid chromatographic assay suitable for pharmacokinetic studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::770d3fe931aeee814ec82f6d06bd5264
https://pubmed.ncbi.nlm.nih.gov/2322319

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Multi-dimensional high-performance liquid chromatography of opioid peptides following pre-column derivatization with naphthalene-2,3-dicarboxaldehyde in the presence of cyanide ion. Preliminary results on the determination of leucine- and methionine-enkephalin-like fluorescence in the striatum region of the rat brain

Autor: M, Mifune, D K, Krehbiel, J F, Stobaugh, C M, Riley

Publikováno v: Journal of chromatography. 496(1)

The reversed-phase high-performance liquid chromatography of three synthetic opioid peptides, 5leucine-enkephalin, 5methionine-enkephalin and [D-2alanine]-5methionine enkephalin, has been studied after their pre-column fluorogenic derivatization with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::18de98d7707cd24b638f7989dca7025f
https://pubmed.ncbi.nlm.nih.gov/2592517

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